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Select item 108282691.

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

Richard Venz, Anita Goyala, Abel Soto-Gamez, Tugce Yenice, Marco Demaria, Collin Y. Ewald

GeroScience. 2024 Apr; 46(2): 1499–1514. Published online 2023 Aug 29. doi: 10.1007/s11357-023-00909-z

PMCID:: PMC10828269

Article PDF–3.0M

Select item 105616932.

UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting

Cody J. Drozd, Christopher C. Quinn

Development. 2023 Sep 15; 150(18): dev201654. Published online 2023 Sep 27. doi: 10.1242/dev.201654

PMCID:: PMC10561693

Article

Select item 105234693.

An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration

Yue Sun, Yishi Jin

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2302801120. Published online 2023 Sep 18. doi: 10.1073/pnas.2302801120

PMCID:: PMC10523469

Article PDF–2.4M

Select item 103231294.

Optimized protocol for in vivo affinity purification proteomics and biochemistry using C. elegans

Muriel Desbois, Joseph S. Pak, Karla J. Opperman, Andrew C. Giles, Brock Grill

STAR Protoc. 2023 Jun 16; 4(2): 102262. Published online 2023 Jun 8. doi: 10.1016/j.xpro.2023.102262

PMCID:: PMC10323129

Article PDF–6.8M

Select item 103197775.

Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects

Lama AlAbdi, Muriel Desbois, Domniţa-Valeria Rusnac, Raashda A Sulaiman, Jill A Rosenfeld, Seema Lalani, David R Murdock, Lindsay C Burrage, Undiagnosed Diseases Network, Ping Yee Billie Au, Shelley Towner, William G Wilson, Lawrence Wong, Theresa Brunet, Gertrud Strobl-Wildemann, Jennifer E Burton, George Hoganson, Kirsty McWalter, Amber Begtrup, Yuri A Zarate, Elyse L Christensen, Karla J Opperman, Andrew C Giles, Rana Helaby, Artur Kania, Ning Zheng, Brock Grill, Fowzan S Alkuraya

Brain. 2023 Apr; 146(4): 1373–1387. Published online 2022 Oct 6. doi: 10.1093/brain/awac364

PMCID:: PMC10319777

Article PDF–1.1M

Select item 90735546.

A mutation linked to degt-1(ok3307) in C. elegans strain VC2633 affects rpm-1

Eugene Jennifer Jin, Yishi Jin

MicroPubl Biol. 2022; 2022: 10.17912/micropub.biology.000565. Published online 2022 May 5. doi: 10.17912/micropub.biology.000565

PMCID:: PMC9073554

Article PDF–526K

Select item 90418347.

Ubiquitin ligase activity inhibits Cdk5 to control axon termination

Muriel Desbois, Karla J. Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill

PLoS Genet. 2022 Apr; 18(4): e1010152. Published online 2022 Apr 14. doi: 10.1371/journal.pgen.1010152

PMCID:: PMC9041834

Article PDF–2.7M

Select item 80040218.

Molecular Basis of Neuronal Autophagy in Ageing: Insights from Caenorhabditis elegans

Georgios Konstantinidis, Nektarios Tavernarakis

Cells. 2021 Mar; 10(3): 694. Published online 2021 Mar 21. doi: 10.3390/cells10030694

PMCID:: PMC8004021

Article PDF–1.0M

Select item 79951769.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4

PMCID:: PMC7995176

Article PDF–1.0M

Select item 732813210.

Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans

Chaogu Zheng, Emily Atlas, Ho Ming Terence Lee, Susan Laura Javier Jao, Ken C. Q. Nguyen, David H. Hall, Martin Chalfie

Development. 2020 Jun 15; 147(12): dev189886. Published online 2020 Jun 17. doi: 10.1242/dev.189886

PMCID:: PMC7328132

Article

Select item 682519911.

Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Oliver Crawley, Karla J. Opperman, Muriel Desbois, Isabel Adrados, Melissa A. Borgen, Andrew C. Giles, Derek R. Duckett, Brock Grill

Nat Commun. 2019; 10: 5017. Published online 2019 Nov 1. doi: 10.1038/s41467-019-12804-3

PMCID:: PMC6825199

Article PDF–4.4M

Select item 667110112.

RPM-1, a Caenorhabditis elegans Protein That Functions in Presynaptic Differentiation, Negatively Regulates Axon Outgrowth by Controlling SAX-3/robo and UNC-5/UNC5 Activity

Haichang Li, Gauri Kulkarni, William G. Wadsworth

J Neurosci. 2008 Apr 2; 28(14): 3595–3603. doi: 10.1523/JNEUROSCI.5536-07.2008

PMCID:: PMC6671101

Article PDF–595K

Select item 635519213.

Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub

Melissa A Borgen, Andrew C Giles, Dandan Wang, Brock Grill

eLife. 2019; 8: e44040. Published online 2019 Jan 18. doi: 10.7554/eLife.44040

PMCID:: PMC6355192

Article PDF–5.9M

Select item 621659014.

OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes

Woojin Kim, Ryan S. Underwood, Iva Greenwald, Daniel D. Shaye

Genetics. 2018 Oct; 210(2): 445–461. Published online 2018 Aug 17. doi: 10.1534/genetics.118.301307

PMCID:: PMC6216590

Article PDF–1.4M

Select item 617693415.

RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling

Eun Chan Park, Christopher Rongo

Development. 2018 Sep 15; 145(18): dev164897. Published online 2018 Sep 21. doi: 10.1242/dev.164897

PMCID:: PMC6176934

Article

Select item 613095016.

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

Muriel Desbois, Oliver Crawley, Paul R. Evans, Scott T. Baker, Ikuo Masuho, Ryohei Yasuda, Brock Grill

J Biol Chem. 2018 Sep 7; 293(36): 13897–13909. Published online 2018 Jul 11. doi: 10.1074/jbc.RA118.002176

PMCID:: PMC6130950

Article PDF–2.5M

Select item 582801517.

Distinct cis elements in the 3′ UTR of the C. elegans cebp-1 mRNA mediate its regulation in neuronal development

Panid Sharifnia, Kyung Won Kim, Zilu Wu, Yishi Jin

Dev Biol. Author manuscript; available in PMC 2018 Feb 27.

Published in final edited form as: Dev Biol. 2017 Sep 1; 429(1): 240–248. Published online 2017 Jun 30. doi: 10.1016/j.ydbio.2017.06.022

PMCID:: PMC5828015

Article PDF–956K

Select item 576962218.

RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability

Melissa A. Borgen, Dandan Wang, Brock Grill

Development. 2017 Dec 15; 144(24): 4658–4672. doi: 10.1242/dev.154187

PMCID:: PMC5769622

Article

Select item 575420819.

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning

Oliver Crawley, Andrew C. Giles, Muriel Desbois, Sudhanva Kashyap, Rayna Birnbaum, Brock Grill

PLoS Genet. 2017 Dec; 13(12): e1007095. Published online 2017 Dec 11. doi: 10.1371/journal.pgen.1007095

PMCID:: PMC5754208

Article PDF–28M

Select item 570327220.

Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegans

Zehra C. Abay, Michelle Yu-Ying Wong, Jean-Sébastien Teoh, Tarika Vijayaraghavan, Massimo A. Hilliard, Brent Neumann

Proc Natl Acad Sci U S A. 2017 Nov 21; 114(47): E10196–E10205. Published online 2017 Nov 6. doi: 10.1073/pnas.1703807114

PMCID:: PMC5703272

Article PDF–1.1M

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