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Items: 1 to 20 of 75

1.
Thorase deficiency causes both Aβ accumulation and tau hyperphosphorylation in mouse brain
Han Zhang, Menghua Cai, Fei Gao, Jia Yang, Chao Li, Jingyi Han, Yue Wang, Yi Xu, Yu Hu, Hui Chen, Wei He, Jianmin Zhang
Alzheimers Dement. 2024 Dec; 20(12): 8769–8786. Published online 2024 Nov 13. doi: 10.1002/alz.14329
PMCID:
PMC11667493
ArticlePDF–9.3M
2.
Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes
Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Masaya Oshima, Anna Moser, Marie-Andrée Bessard, Abdelaziz Gdoura, Kevin Roger, Nina Mode, Joanna Lipecka, Ayse Yilmaz, Barbara Bertocci, Julien Diana, Benjamin Saintpierre, Ida Chiara Guerrera, Raphael Scharfmann, Stefania Francesconi, François-Xavier Mauvais, Peter van Endert
iScience. 2024 Jun 21; 27(6): 109929. Published online 2024 May 7. doi: 10.1016/j.isci.2024.109929
PMCID:
PMC11126816
ArticlePDF–4.6M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
4.
Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornina
J Neuroinflammation. 2023; 20: 233. Published online 2023 Oct 11. doi: 10.1186/s12974-023-02914-7
PMCID:
PMC10566021
ArticlePDF–7.2M
5.
Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired Motor Coordination Behavior
Chao Li, Han Zhang, Kexin Tong, Menghua Cai, Fei Gao, Jia Yang, Yi Xu, Huaishan Wang, Hui Chen, Yu Hu, Wei He, Jianmin Zhang
Cells. 2023 Aug; 12(16): 2032. Published online 2023 Aug 10. doi: 10.3390/cells12162032
PMCID:
PMC10453921
ArticlePDF–6.2M
6.
The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle
Dina Aweida, Shenhav Cohen
EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175
PMCID:
PMC9724657
ArticlePDF–3.0M
7.
ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson’s Disease-like Behavior
Fei Gao, Han Zhang, Jia Yang, Menghua Cai, Qi Yang, Huaishan Wang, Yi Xu, Hui Chen, Yu Hu, Wei He, Jianmin Zhang
Cells. 2022 Oct; 11(19): 2990. Published online 2022 Sep 26. doi: 10.3390/cells11192990
PMCID:
PMC9563720
ArticlePDF–5.4M
8.
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Beatriz Merino, Elena Casanueva-Álvarez, Iván Quesada, Carlos M. González-Casimiro, Cristina M. Fernández-Díaz, Tamara Postigo-Casado, Malcolm A. Leissring, Klaus H. Kaestner, Germán Perdomo, Irene Cózar-Castellano
Diabetologia. 2022; 65(8): 1375–1389. Published online 2022 Jun 2. doi: 10.1007/s00125-022-05729-y
Correction in:
Diabetologia. 2024; 67(1): 218–219.
PMCID:
PMC9283140
ArticlePDF–1.8M
9.
Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model
Ofir Fursht, Mirit Liran, Yuval Nash, Vijay Krishna Medala, Dor Ini, Tabitha Grace Royal, Guy Goldsmith, Limor Nahary, Itai Benhar, Dan Frenkel
Front Immunol. 2022; 13: 835774. Published online 2022 Mar 8. doi: 10.3389/fimmu.2022.835774
PMCID:
PMC8958001
ArticlePDF–2.0M
10.
Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells
Miriam Corraliza-Gómez, Concepción Lillo, Irene Cózar-Castellano, Eduardo Arranz, Diego Sanchez, Maria D. Ganfornina
Cells. 2022 Jan; 11(2): 227. Published online 2022 Jan 11. doi: 10.3390/cells11020227
PMCID:
PMC8774118
ArticlePDF–4.1M
11.
Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
Beatriz Merino, Cristina M. Fernández-Díaz, Cristina Parrado-Fernández, Carlos M. González-Casimiro, Tamara Postigo-Casado, Carmen D. Lobatón, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo
Metabolism. Author manuscript; available in PMC 2021 Nov 25.
Published in final edited form as: Metabolism. 2020 Dec; 113: 154352. Published online 2020 Sep 9. doi: 10.1016/j.metabol.2020.154352
PMCID:
PMC8616598
ArticlePDF–1.7M
12.
Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme
Janine Mett, Anna A. Lauer, Daniel Janitschke, Lea V. Griebsch, Elena L. Theiss, Heike S. Grimm, Hennariikka Koivisto, Heikki Tanila, Tobias Hartmann, Marcus O. W. Grimm
Cells. 2021 Nov; 10(11): 2941. Published online 2021 Oct 29. doi: 10.3390/cells10112941
PMCID:
PMC8616162
ArticlePDF–1.1M
13.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
ArticlePDF–1.6M
14.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
ArticlePDF–2.0M
15.
AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF
George K.E. Umanah, Mehdi Ghasemi, Xiling Yin, Melissa Chang, Jin Wan Kim, Jianmin Zhang, Erica Ma, Leslie A. Scarffe, Yun-Il Lee, Rong Chen, Kavya Tangella, Amy McNamara, Leire Abalde-Atristain, Mohamad A. Dar, Samuel Bennett, Marisol Cortes, Shaida A. Andrabi, Paschalis-Thomas Doulias, Harry Ischiropoulos, Ted M. Dawson, Valina L. Dawson
Cell Rep. Author manuscript; available in PMC 2020 Dec 15.
Published in final edited form as: Cell Rep. 2020 Nov 3; 33(5): 108329. doi: 10.1016/j.celrep.2020.108329
PMCID:
PMC7737632
ArticlePDF–2.3M
16.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
ArticlePDF–2.0M
17.
Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity
Cristina M. Fernández-Díaz, Beatriz Merino, José F. López-Acosta, Pilar Cidad, Miguel A. de la Fuente, Carmen D. Lobatón, Alfredo Moreno, Malcolm A. Leissring, Germán Perdomo, Irene Cózar-Castellano
Am J Physiol Endocrinol Metab. 2019 Nov 1; 317(5): E805–E819. Published online 2019 Sep 3. doi: 10.1152/ajpendo.00040.2019
PMCID:
PMC7132327
Article
18.
Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention
Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P. Lim, Surendra S. Ambegaokar, Oliver J. Ubeda, Sally A. Frautschy, Greg M. Cole
J Neurosci. 2004 Dec 8; 24(49): 11120–11126. doi: 10.1523/JNEUROSCI.2860-04.2004
PMCID:
PMC6730264
ArticlePDF–294K
19.
The AAA + ATPase Thorase is neuroprotective against ischemic injury
Jianmin Zhang, Jia Yang, Huaishan Wang, Omar Sherbini, Matthew J Keuss, George KE Umanah, Emily Ling-Lin Pai, Zhikai Chi, Kaisa MA Paldanius, Wei He, Hong Wang, Shaida A Andrabi, Ted M Dawson, Valina L Dawson
J Cereb Blood Flow Metab. 2019 Sep; 39(9): 1836–1848. Published online 2018 Apr 16. doi: 10.1177/0271678X18769770
PMCID:
PMC6727130
ArticlePDF–1.7M
20.
Thorase variants cause defects in glutamatergic signaling and behavioral deficits: rescue by Perampanel.
George K.E. Umanah, Marco Pignatelli, Xiling Yin, Rong Chen, Joshua Crawford, Stewart Neifert, Leslie Scarffe, Adam A. Behensky, Noah Guiberson, Melissa Chang, Erica Ma, Jin Wan Kim, Cibele C. Castro, Xiaobo Mao, Li Chen, Shaida A. Andrabi, Mikhail V. Pletnikov, Ann E. Pulver, Dimitrios Avramopoulos, Antonello Bonci, David Valle, Ted M. Dawson, Valina L. Dawson
Sci Transl Med. Author manuscript; available in PMC 2019 Jun 17.
Published in final edited form as: Sci Transl Med. 2017 Dec 13; 9(420): eaah4985. doi: 10.1126/scitranslmed.aah4985
PMCID:
PMC6573025
ArticlePDF–1.1M

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