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Select item 111598401.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer

Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park

Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x

PMCID:: PMC11159840

Abstract Article PDF–209K

Select item 111158722.

Role of Chk1 in the differentiation program of hematopoietic stem cells

Laura Carrassa, Elisa Montelatici, Lorenza Lazzari, Stefano Zangrossi, Matteo Simone, Massimo Broggini, Giovanna Damia

Cell Mol Life Sci. 2010 May; 67(10): 1713–1722. Published online 2010 Feb 10. doi: 10.1007/s00018-010-0274-1

PMCID:: PMC11115872

Abstract Article PDF–367K

Select item 111094833.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110989614.

The luciferase-based in vivo protein–protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction

Sana Ando, Keiko Tanaka, Maharu Matsumoto, Yuki Oyama, Yuri Tomabechi, Atsushi Yamagata, Mikako Shirouzu, Reiko Nakagawa, Noriaki Okimoto, Makoto Taiji, Koichi Sato, Takashi Ohama

J Biol Chem. 2024 May; 300(5): 107277. Published online 2024 Apr 6. doi: 10.1016/j.jbc.2024.107277

PMCID:: PMC11098961

Abstract Article PDF–1.2M

Select item 108508185.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 106895036.

CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

Rishi Kumar Jaiswal, Kai-Hang Lei, Megan Chastain, Yuan Wang, Olga Shiva, Shan Li, Zhongsheng You, Peter Chi, Weihang Chai

Nat Commun. 2023; 14: 7882. Published online 2023 Nov 30. doi: 10.1038/s41467-023-43685-2

PMCID:: PMC10689503

Abstract Article PDF–5.2M

Select item 105476477.

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity

Qiankun Luo, Yanfeng Pan, Qiang Fu, Xu Zhang, Shuai Zhou, Pengfei Yu, Huiyuan Tian, Pan Liu, Song Chen, Hongwei Zhang, Tao Qin

Cell Biol Toxicol. 2023; 39(5): 2069–2087. Published online 2022 Feb 10. doi: 10.1007/s10565-022-09695-4

PMCID:: PMC10547647

Abstract Article PDF–9.5M

Select item 105418848.

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Devashish Dwivedi, Daniela Harry, Patrick Meraldi

Nat Commun. 2023; 14: 6088. Published online 2023 Sep 29. doi: 10.1038/s41467-023-41753-1

PMCID:: PMC10541884

Abstract Article PDF–9.6M

Select item 105302719.

Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

Feng Jiang, Xiaolu Huang, Liqun Ling, Shiyi Tang, Huixin Zhou, Xueding Cai, Yumin Wang

Int J Mol Sci. 2023 Sep; 24(18): 13925. Published online 2023 Sep 10. doi: 10.3390/ijms241813925

PMCID:: PMC10530271

Abstract Article PDF–7.0M

Select item 1027947210.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1000824613.

The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study

Mohammed Alorjani, Manar Aburub, Bahaa Al-Trad, Mohammad Al Hamad, Manal AbuAlarja, Samir Al Bashir, Khalid Al-Batayneh, Mazhar Al Zoubi

Med Arch. 2023 Feb; 77(1): 8–12. doi: 10.5455/medarh.2023.77.8-12

PMCID:: PMC10008246

Abstract Article PDF–340K

Select item 985562014.

Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses

Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai

Biomolecules. 2023 Jan; 13(1): 125. Published online 2023 Jan 7. doi: 10.3390/biom13010125

Correction in:: Biomolecules. 2023 Jul; 13(7): 1145.

PMCID:: PMC9855620

Abstract Article PDF–9.6M

Select item 977981315.

PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells

Sol Lee, Ha-Yeon Jee, Yoon-Gyeong Lee, Jong-Il Shin, Yong-Joon Jeon, Ji-Beom Kim, Hye-eun Seo, Ji-Yeon Lee, Kyungho Lee

Int J Mol Sci. 2022 Dec; 23(24): 15872. Published online 2022 Dec 14. doi: 10.3390/ijms232415872

PMCID:: PMC9779813

Abstract Article PDF–2.2M

Select item 976969816.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 961539217.

MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer

Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang, Jing Gao

Cell Commun Signal. 2022; 20: 170. Published online 2022 Oct 28. doi: 10.1186/s12964-022-00984-3

PMCID:: PMC9615392

Abstract Article PDF–13M

Select item 959675618.

Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm

Ji Chen, Mengjiao Sun, Chuqin Chen, Bin Jiang, Yongjun Fang

Front Immunol. 2022; 13: 1016683. Published online 2022 Oct 12. doi: 10.3389/fimmu.2022.1016683

PMCID:: PMC9596756

Abstract Article PDF–4.6M

Select item 936931219.

Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors

Silvia Paukovcekova, Maria Krchniakova, Petr Chlapek, Jakub Neradil, Jan Skoda, Renata Veselska

Int J Mol Sci. 2022 Aug; 23(15): 8549. Published online 2022 Aug 1. doi: 10.3390/ijms23158549

PMCID:: PMC9369312

Abstract Article PDF–4.3M

Select item 936538520.

Aberrant Activation of Cell-Cycle–Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma

Kosuke Yoshida, Akira Yokoi, Tomofumi Yamamoto, Yusuke Hayashi, Jun Nakayama, Tsuyoshi Yokoi, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto

Clin Cancer Res. 2022 May 13; 28(10): 2147–2159. Published online 2022 Mar 18. doi: 10.1158/1078-0432.CCR-22-0100