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Select item 111592781.

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

Masashi Takawa, Ken Masuda, Masaki Kunizaki, Yataro Daigo, Katsunori Takagi, Yukiko Iwai, Hyun‐Soo Cho, Gouji Toyokawa, Yuka Yamane, Kazuhiro Maejima, Helen I. Field, Takaaki Kobayashi, Takayuki Akasu, Masanori Sugiyama, Eijyu Tsuchiya, Yutaka Atomi, Bruce A. J. Ponder, Yusuke Nakamura, Ryuji Hamamoto

Cancer Sci. 2011 Jul; 102(7): 1298–1305. Published online 2011 May 26. doi: 10.1111/j.1349-7006.2011.01958.x

PMCID:: PMC11159278

Abstract Article PDF–563K

Select item 111590192.

Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer

Yasuko Matsukawa, Shuho Semba, Hirotaka Kato, Akihiko Ito, Kazuyoshi Yanagihara, Hiroshi Yokozaki

Cancer Sci. 2006 Jun; 97(6): 484–491. Published online 2006 May 26. doi: 10.1111/j.1349-7006.2006.00203.x

PMCID:: PMC11159019

Abstract Article PDF–214K

Select item 105126483.

Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts

Lei Zhang, Huan-Huan Liu, Fan Yang, Zhi-Yuan Zhang, Ying Wu, Feng Li, Shi-Peng Dang, Zhen-Ye Zhang, Ling-Ling Qian, Ru-Xing Wang

BMC Cardiovasc Disord. 2023; 23: 474. Published online 2023 Sep 21. doi: 10.1186/s12872-023-03492-5

PMCID:: PMC10512648

Abstract Article PDF–5.0M

Select item 98977914.

Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho

Qinglian Wang, Jingshu Sun, Rong Wang, Jing Sun

Ren Fail. 2023; 45(1): 2149411. Published online 2023 Feb 1. doi: 10.1080/0886022X.2022.2149411

PMCID:: PMC9897791

Abstract Article PDF–2.7M

Select item 98128085.

EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway

Nan Zhu, Haochen Guan, Xuan Wang, Yueyue Zhang, Lijie Gu, Jieshuang Jia, Ling Wang, Weijie Yuan

Int J Med Sci. 2023; 20(1): 114–124. Published online 2023 Jan 1. doi: 10.7150/ijms.78428

PMCID:: PMC9812808

Abstract Article PDF–5.6M

Select item 90922746.

Inhibition of histone methyltransferase EZH2 suppresses endometriotic vesicle development in a rat model of endometriosis

Inevy Seguinot, Nuria Luna, Edu Suarez, Caroline B. Appleyard, Idhaliz Flores

Reprod Sci. Author manuscript; available in PMC 2022 May 11.

Published in final edited form as: Reprod Sci. 2020 Sep; 27(9): 1812–1820. Published online 2020 Jul 10. doi: 10.1007/s43032-020-00257-9

PMCID:: PMC9092274

Abstract Article PDF–745K

Select item 89736157.

Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization

Xuezhu Huang, Qin Yang, Lingling Xie, Sihong Lei

Bioengineered. 2022; 13(3): 5509–5524. Published online 2022 Feb 17. doi: 10.1080/21655979.2022.2036892

PMCID:: PMC8973615

Abstract Article PDF–2.6M

Select item 81596428.

EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury

Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

Mediators Inflamm. 2021; 2021: 5591582. Published online 2021 May 19. doi: 10.1155/2021/5591582

PMCID:: PMC8159642

Abstract Article PDF–1.6M

Select item 81391069.

Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain

Qi An, Chenyan Sun, Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An, Zhaojin Wang

J Neuroinflammation. 2021; 18: 117. Published online 2021 May 21. doi: 10.1186/s12974-021-02168-1

PMCID:: PMC8139106

Abstract Article PDF–4.2M

Select item 812037610.

Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger

ESC Heart Fail. 2021 Jun; 8(3): 1873–1884. Published online 2021 Mar 28. doi: 10.1002/ehf2.13297

PMCID:: PMC8120376

Abstract Article PDF–977K

Select item 799912011.

Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach

Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, Vinod Krishna, Sandra Breuils-Bonnet, Eve Tremblay, Ghada Mkannez, Sandra Martineau, Valérie Nadeau, Florence Roux-Dalvai, Mark Orcholski, Jey Jeyaseelan, David Gutstein, François Potus, Steeve Provencher, Sébastien Bonnet, Roxane Paulin, Olivier Boucherat

Int J Mol Sci. 2021 Mar; 22(6): 2957. Published online 2021 Mar 15. doi: 10.3390/ijms22062957

PMCID:: PMC7999120

Abstract Article PDF–8.0M

Select item 772543112.

Inhibition of EZH2 attenuates neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB in a rat model of subarachnoid hemorrhage

Yujie Luo, Yuanjian Fang, Ruiqing Kang, Cameron Lenahan, Marcin Gamdzyk, Zeyu Zhang, Takeshi Okada, Jiping Tang, Sheng Chen, John H Zhang

Stroke. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Stroke. 2020 Nov; 51(11): 3320–3331. Published online 2020 Sep 16. doi: 10.1161/STROKEAHA.120.029951

Correction in:: Stroke. 2024 Jul; 55(7): e233.

PMCID:: PMC7725431

Abstract Article PDF–1.6M

Select item 768108513.

Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Yan Jiang, Chan Xiang, Fan Zhong, Yang Zhang, Liyan Wang, Yuanyuan Zhao, Jiucun Wang, Chen Ding, Li Jin, Fuchu He, Haijian Wang

Theranostics. 2021; 11(1): 361–378. Published online 2021 Jan 1. doi: 10.7150/thno.46360

PMCID:: PMC7681085

Abstract Article PDF–4.4M

Select item 734072114.

Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibiting Autophagy Following Brachial Plexus Avulsion in Rats

Xiang-Lei Meng, Pengfei Fu, Lin Wang, Xun Yang, Guanghui Hong, Xin Zhao, Jie Lao

Neurosci Bull. 2020 Jul; 36(7): 793–805. Published online 2020 Apr 28. doi: 10.1007/s12264-020-00502-w

PMCID:: PMC7340721

Abstract Article PDF–2.7M

Select item 710098715.

The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2

Gang Li, Haifeng Liu, Xiaogang Zhang, Xingchao Liu, Guodong Zhang, Qinghe Liu

Cell Cycle. 2020; 19(5): 551–566. Published online 2020 Feb 13. doi: 10.1080/15384101.2020.1717043

Expression of Concern in:: Cell Cycle. 2023; 22(1): 149.

PMCID:: PMC7100987

Abstract Article PDF–3.0M

Select item 705656216.

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells

Daniel Moena, Gino Nardocci, Elvis Acevedo, Jane Lian, Gary Stein, Janet Stein, Martin Montecino

J Cell Physiol. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: J Cell Physiol. 2020 Jun; 235(6): 5404–5412. Published online 2020 Jan 7. doi: 10.1002/jcp.29428

PMCID:: PMC7056562

Abstract Article PDF–559K

Select item 673938217.

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment

Xiaozhen Gu, Yi Xu, Wei-Zhen Xue, Yulan Wu, Zi Ye, Guiran Xiao, Hui-Li Wang

Cell Death Dis. 2019 Sep; 10(9): 671. Published online 2019 Sep 11. doi: 10.1038/s41419-019-1912-7

PMCID:: PMC6739382

Abstract Article PDF–2.7M

Select item 671027818.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron

Nat Commun. 2019; 10: 3858. Published online 2019 Aug 26. doi: 10.1038/s41467-019-11800-x

PMCID:: PMC6710278

Abstract Article PDF–4.1M

Select item 655991119.

DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators

EVANGELIA LEGAKI, CHRISTOS KLONARIS, DIMITRIOS ATHANASIADIS, NIKOLAOS PATELIS, ANNA SIOZIOU, THEODOROS LIAKAKOS, MARIA GAZOULI

In Vivo. 2019 May-Jun; 33(3): 737–742. Published online 2019 May 3. doi: 10.21873/invivo.11533

PMCID:: PMC6559911

Abstract Article PDF–182K

Select item 654771220.

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

Jie Zhou, Shuo Huang, Zhongyu Wang, Jiani Huang, Liang Xu, Xuefeng Tang, Yisong Y. Wan, Qi-jing Li, Alistair L. J. Symonds, Haixia Long, Bo Zhu

Nat Commun. 2019; 10: 2427. Published online 2019 Jun 3. doi: 10.1038/s41467-019-10176-2

PMCID:: PMC6547712

Abstract Article PDF–2.8M

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