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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108615182.

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang, Linli Que, Guoqing Zhu, Li Liu, Qi Chen, Chuanfu Li, Guoqiang Shao, Yuehua Li, Jiantao Li

Cell Death Dis. 2024 Feb; 15(2): 135. Published online 2024 Feb 12. doi: 10.1038/s41419-024-06470-7

PMCID:: PMC10861518

Abstract Article PDF–6.3M

Select item 102525283.

Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model

Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R. Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik

Cells. 2023 Jun; 12(11): 1527. Published online 2023 Jun 1. doi: 10.3390/cells12111527

PMCID:: PMC10252528

Abstract Article PDF–8.3M

Select item 100388644.

Pellino1 restricts herpes simplex virus infections in the epidermis and dissemination to sebaceous glands

Kathy Q. Cai, Caitlin Shellhamer, Tasuku Akiyama, Liselotte E. Jensen

J Invest Dermatol. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: J Invest Dermatol. 2023 Apr; 143(4): 639–647.e2. Published online 2022 Oct 8. doi: 10.1016/j.jid.2022.09.007

PMCID:: PMC10038864

Abstract Article PDF–1.9M

Select item 92653415.

The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression

Fabienne Burger, Daniela Baptista, Aline Roth, Karim J. Brandt, Kapka Miteva

Cells. 2022 Jul; 11(13): 2014. Published online 2022 Jun 23. doi: 10.3390/cells11132014

PMCID:: PMC9265341

Abstract Article PDF–2.7M

Select item 90145596.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 89245957.

miR-590-5p Overexpression Alleviates β-Amyloid-Induced Neuron Damage via Targeting Pellino-1

Lin Shang, Tao Peng, Xuemei Chen, Zhiyong Yan, Junmin Wang, Xiaoqun Gao, Cheng Chang

Anal Cell Pathol (Amst) 2022; 2022: 7657995. Published online 2022 Mar 8. doi: 10.1155/2022/7657995

PMCID:: PMC8924595

Abstract Article PDF–3.5M

Select item 84218468.

Transforming Growth Factor-β1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis

Yongqi Wang, Xiaoqing Wang, Hong Zhang, Biao Han, Yuanmei Ye, Mengjie Zhang, Yingbin Wang, Jianjun Xue, Chun’ai Wang

Front Cell Infect Microbiol. 2021; 11: 693981. Published online 2021 Aug 24. doi: 10.3389/fcimb.2021.693981

PMCID:: PMC8421846

Abstract Article PDF–2.9M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 811564510.

The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity

Xinfang Huang, Shumeng Hao, Junli Liu, Yuanyuan Huang, Manman Liu, Chunyuan Xiao, Yan Wang, Siyu Pei, Tao Yu, Jing Xu, Haikun Wang, Dongfang Dai, Xiao Su, Yichuan Xiao

Cell Mol Immunol. 2021 Apr; 18(4): 969–978. Published online 2021 Mar 11. doi: 10.1038/s41423-021-00660-5

PMCID:: PMC8115645

Abstract Article PDF–3.5M

Select item 808072111.

Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response

Suhyeon Kim, Si-Yeon Lee, Seoyoon Bae, Jin-Kwan Lee, Kyungrim Hwang, Heounjeong Go, Chang-Woo Lee

Exp Mol Med. 2020 Sep; 52(9): 1537–1549. Published online 2020 Sep 1. doi: 10.1038/s12276-020-00489-4

PMCID:: PMC8080721

Abstract Article PDF–1.9M

Select item 780970212.

The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses

Chun‐Jung Ko, Lingyun Zhang, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Jin‐Young Yang, Xuhong Cheng, Shao‐Cong Sun

EMBO J. 2021 Jan 15; 40(2): e104532. Published online 2020 Nov 20. doi: 10.15252/embj.2020104532

PMCID:: PMC7809702

Abstract Article PDF–1.9M

Select item 756113613.

Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation

Jing Xu, Tao Yu, Enrica Caterina Pietronigro, Jia Yuan, Jessica Arioli, Yifei Pei, Xuan Luo, Jialin Ye, Gabriela Constantin, Chaoming Mao, Yichuan Xiao

PLoS Biol. 2020 Oct; 18(10): e3000837. Published online 2020 Oct 5. doi: 10.1371/journal.pbio.3000837

PMCID:: PMC7561136

Abstract Article PDF–2.5M

Select item 754600714.

Redox DAPK1 destabilizes Pellino1 to govern inflammation-coupling tubular damage during septic AKI

Bang-Chuan Hu, Guo-Hua Wu, Zi-Qiang Shao, Yang Zheng, Jin-Quan Liu, Run Zhang, Jun Hong, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo

Theranostics. 2020; 10(25): 11479–11496. Published online 2020 Sep 15. doi: 10.7150/thno.49870

PMCID:: PMC7546007

Abstract Article PDF–3.4M

Select item 729731015.

Peli1 signaling blockade attenuates congenital zika syndrome

Huanle Luo, Guangyu Li, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, Bi-Hung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R. Winkelmann, Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D. T. Barrett, Shao-Cong Sun, Wenbo Zhang, Pei-Yong Shi, Ping Wu, Tian Wang

PLoS Pathog. 2020 Jun; 16(6): e1008538. Published online 2020 Jun 16. doi: 10.1371/journal.ppat.1008538

PMCID:: PMC7297310

Abstract Article PDF–2.8M

Select item 707170116.

Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord

Lijuan Wang, Cui Yin, Tianya Liu, Mannan Abdul, Yan Zhou, Jun-Li Cao, Chen Lu

J Neuroinflammation. 2020; 17: 83. Published online 2020 Mar 14. doi: 10.1186/s12974-020-01754-z

PMCID:: PMC7071701

Abstract Article PDF–3.6M

Select item 682907317.

Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth

Donghyun Kim, Jaemoon Koh, Jae Sung Ko, Hye Young Kim, Ho Lee, Doo Hyun Chung

Immune Netw. 2019 Oct; 19(5): e32. Published online 2019 Oct 17. doi: 10.4110/in.2019.19.e32

PMCID:: PMC6829073

Abstract Article PDF–1.4M

Select item 675307618.

HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage

Yajun Xie, Xiaoyan Lv, Dongsheng Ni, Jianing Liu, Yanxia Hu, Yamin Liu, Yunhong Liu, Rui Liu, Hui Zhao, Zhimin Lu, Qin Zhou

Nat Commun. 2019; 10: 4266. Published online 2019 Sep 19. doi: 10.1038/s41467-019-12011-0

PMCID:: PMC6753076

Abstract Article PDF–2.4M

Select item 672539419.

Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes

Alessandro Bulfone, Pietro Carotenuto, Andrea Faedo, Veruska Aglio, Livia Garzia, Anna Maria Bello, Andrea Basile, Alessandra Andrè, Massimo Cocchia, Ombretta Guardiola, Andrea Ballabio, John L. R. Rubenstein, Massimo Zollo

J Neurosci. 2005 Aug 17; 25(33): 7586–7600. doi: 10.1523/JNEUROSCI.0522-05.2005

PMCID:: PMC6725394

Abstract Article PDF–682K

Select item 668534820.

Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease

Bethany M. Hughes, Charlotte S. Burton, Abigail Reese, Maisha F. Jabeen, Carl Wright, Jessica Willis, Nika Khoshaein, Elizabeth K. Marsh, Peter Peachell, Shao C. Sun, David H. Dockrell, Helen M. Marriott, Ian Sabroe, Alison M. Condliffe, Lynne R. Prince

Front Immunol. 2019; 10: 1721. Published online 2019 Jul 31. doi: 10.3389/fimmu.2019.01721

PMCID:: PMC6685348

Abstract Article PDF–1.3M

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