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Items: 1 to 20 of 53

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization
Wen-Jun Shen, Yuan Cortez, Amar Singh, Weiqin Chen, Salman Azhar, Fredric B. Kraemer
J Lipid Res. 2022 Dec; 63(12): 100309. Published online 2022 Nov 1. doi: 10.1016/j.jlr.2022.100309
PMCID:
PMC9703635
AbstractArticlePDF–2.7M
3.
BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism
Hongyi Zhou, Jie Li, Huabo Su, Ji Li, Todd A. Lydic, Martin E Young, Weiqin Chen
Clin Transl Med. 2022 Apr; 12(4): e736. Published online 2022 Apr 5. doi: 10.1002/ctm2.736
PMCID:
PMC8982503
AbstractArticlePDF–4.2M
4.
Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity
Cody McGrath, Sarah E. Little-Letsinger, Jeyantt Srinivas Sankaran, Buer Sen, Zhihui Xie, Martin A. Styner, Xiaopeng Zong, Weiqin Chen, Janet Rubin, Eric L. Klett, Rosalind A. Coleman, Maya Styner
Front Endocrinol (Lausanne) 2021; 12: 782194. Published online 2022 Jan 25. doi: 10.3389/fendo.2021.782194
PMCID:
PMC8822583
AbstractArticlePDF–22M
5.
Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy
Thiago Bruder-Nascimento, Taylor C. Kress, Matthew Pearson, Weiqin Chen, Simone Kennard, Eric J. Belin de Chantemèle
Int J Mol Sci. 2021 Oct; 22(19): 10596. Published online 2021 Sep 30. doi: 10.3390/ijms221910596
PMCID:
PMC8508873
AbstractArticlePDF–2.1M
6.
Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice
Xiaoyue Wu, Xuejing Liu, Huan Wang, Zihao Zhou, Chengzhi Yang, Zijian Li, Youyi Zhang, XiaoLu Shi, Ling Zhang, Yuhui Wang, Xunde Xian, George Liu, Wei Huang
Front Cardiovasc Med. 2021; 8: 644128. Published online 2021 Mar 11. doi: 10.3389/fcvm.2021.644128
PMCID:
PMC7990891
AbstractArticlePDF–8.2M
7.
Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy
Ahlima Roumane, George D. Mcilroy, Arda Balci, Weiping Han, Mirela Delibegović, Massimiliano Baldassarre, Philip Newsholme, Justin J. Rochford
J Clin Med. 2021 Feb; 10(3): 441. Published online 2021 Jan 23. doi: 10.3390/jcm10030441
PMCID:
PMC7865406
AbstractArticlePDF–1.3M
8.
Berardinelli–Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing
Hongyi Zhou, Cheng Xu, Hakjoo Lee, Yisang Yoon, Weiqin Chen
Mol Metab. 2020 Jun; 36: 100971. Published online 2020 Mar 4. doi: 10.1016/j.molmet.2020.02.014
PMCID:
PMC7136632
AbstractArticlePDF–5.3M
9.
Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford
Dis Model Mech. 2020 Jan 1; 13(1): dmm042655. Published online 2020 Jan 13. doi: 10.1242/dmm.042655
PMCID:
PMC6994952
AbstractArticle
10.
Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
Bo Bai, Wulin Yang, Yanyun Fu, Hannah Lee Foon, Wan Ting Tay, Kangmin Yang, Cuiting Luo, Jayantha Gunaratne, Philip Lee, Michael R. Zile, Aimin Xu, Calvin W.L. Chin, Carolyn S.P. Lam, Weiping Han, Yu Wang
JACC Basic Transl Sci. 2019 Dec; 4(8): 924–937. Published online 2019 Nov 20. doi: 10.1016/j.jacbts.2019.07.008
PMCID:
PMC6939002
AbstractArticlePDF–3.2M
11.
Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy
Thiago Bruder-Nascimento, Jessica L. Faulkner, Stephen Haigh, Simone Kennard, Galina Antonova, Vijay S. Patel, David J.R. Fulton, Weiqin Chen, Eric J. Belin de Chantemèle
Hypertension. Author manuscript; available in PMC 2019 Dec 2.
Published in final edited form as: Hypertension. 2019 Dec; 74(6): 1399–1408. Published online 2019 Oct 28. doi: 10.1161/HYPERTENSIONAHA.119.13398
PMCID:
PMC6886673
AbstractArticlePDF–3.2M
12.
Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy
Hongyi Zhou, Xinnuo Lei, Yun Yan, Todd Lydic, Jie Li, Neal L. Weintraub, Huabo Su, Weiqin Chen
JCI Insight. 2019 Jul 25; 4(14): e129781. Published online 2019 Jul 25. doi: 10.1172/jci.insight.129781
PMCID:
PMC6675548
AbstractArticlePDF–9.7M
13.
Activation of PPARγ Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice
Libin Zhou, Tingting Chen, Guoxi Li, Chaoming Wu, Conghui Wang, Lin Li, Sha Sha, Lei Chen, George Liu, Ling Chen
J Neurosci. 2016 Jan 27; 36(4): 1242–1253. doi: 10.1523/JNEUROSCI.3280-15.2016
PMCID:
PMC6604827
AbstractArticlePDF–2.1M
14.
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
Luis Zurkirchen, Sandra Varum, Sonja Giger, Annika Klug, Jessica Häusel, Raphaël Bossart, Martina Zemke, Claudio Cantù, Zeynep Kalender Atak, Nicola Zamboni, Konrad Basler, Lukas Sommer
Nat Commun. 2019; 10: 2192. Published online 2019 May 16. doi: 10.1038/s41467-019-09823-5
PMCID:
PMC6522535
AbstractArticlePDF–7.1M
15.
Novel Metabolic Disorders in Skeletal Muscle of Lipodystrophic Bscl2/Seipin Deficient Mice
Wenqiong Xu, Hongyi Zhou, Hongzhuan Xuan, Pradip Saha, Gongxian Wang, Weiqin Chen
Mol Cell Endocrinol. Author manuscript; available in PMC 2020 Feb 15.
Published in final edited form as: Mol Cell Endocrinol. 2019 Feb 15; 482: 1–10. Published online 2018 Dec 4. doi: 10.1016/j.mce.2018.12.001
PMCID:
PMC6340772
AbstractArticlePDF–937K
16.
Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford
Sci Rep. 2018; 8: 17863. Published online 2018 Dec 14. doi: 10.1038/s41598-018-36078-9
PMCID:
PMC6294754
AbstractArticlePDF–1.5M
17.
Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
George D. Mcilroy, Karla Suchacki, Anke J. Roelofs, Wulin Yang, Yanyun Fu, Bo Bai, Robert J. Wallace, Cosimo De Bari, William P. Cawthorn, Weiping Han, Mirela Delibegović, Justin J. Rochford
Mol Metab. 2018 Apr; 10: 55–65. Published online 2018 Jan 31. doi: 10.1016/j.molmet.2018.01.019
PMCID:
PMC5985228
AbstractArticlePDF–1.8M
18.
Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation
Ling Wang, Juan Hong, Yajuan Wu, George Liu, Wenfeng Yu, Ling Chen
Cell Death Dis. 2018 May; 9(5): 440. Published online 2018 Apr 18. doi: 10.1038/s41419-018-0471-7
PMCID:
PMC5906676
AbstractArticlePDF–3.2M
19.
Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation
Ahmed E El Zowalaty, Rong Li, Weiqin Chen, Xiaoqin Ye
Biol Reprod. 2018 Apr; 98(4): 570–578. Published online 2017 Dec 11. doi: 10.1093/biolre/iox169
PMCID:
PMC5905587
AbstractArticlePDF–6.6M
20.
CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice
Jin Li, Su-Ping Deng, Gang Wei, Peng Yu
Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012
PMCID:
PMC5868181
AbstractArticlePDF–653K

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