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Select item 112908221.

Structural and dynamic changes in P-Rex1 upon activation by PIP₃ and inhibition by IP₄

Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John JG Tesmer

eLife. 2024; 12: RP92822. Published online 2024 Jul 31. doi: 10.7554/eLife.92822

PMCID:: PMC11290822

Abstract Article PDF–6.2M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 109725993.

PREX1 improves homeostatic proliferation to maintain a naive CD4⁺ T cell compartment in older age

Huimin Zhang, Hirohisa Okuyama, Abhinav Jain, Rohit R. Jadhav, Bowen Wu, Ines Sturmlechner, Jose Morales, Shozo Ohtsuki, Cornelia M. Weyand, Jӧrg J. Goronzy

JCI Insight. 2024 Mar 8; 9(5): e172848. Published online 2024 Feb 8. doi: 10.1172/jci.insight.172848

PMCID:: PMC10972599

Abstract Article PDF–4.9M

Select item 106826994.

P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease

L. Kumarasinghe, M.A. Garcia-Gimeno, J. Ramirez, U. Mayor, JL. Zugaza, P Sanz

Neurobiol Dis. Author manuscript; available in PMC 2023 Nov 28.

Published in final edited form as: Neurobiol Dis. 2023 Feb; 177: 105998. Published online 2023 Jan 10. doi: 10.1016/j.nbd.2023.105998

PMCID:: PMC10682699

Abstract Article PDF–1.7M

Select item 105658765.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105434196.

Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1

Xinyan Gao, Xiaoyan Lin, Mengxin Lin, Yanqin Lan, Yao Wang, Riping Wu, Junde Li, Chuanyong Huang, Dongta Zhong

Turk J Gastroenterol. 2023 Sep; 34(9): 975–981. Published online 2023 Sep 1. doi: 10.5152/tjg.2023.23108

PMCID:: PMC10543419

Abstract Article PDF–1.4M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 93719738.

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon

Nat Struct Mol Biol. 2022; 29(8): 767–773. Published online 2022 Jul 21. doi: 10.1038/s41594-022-00804-9

PMCID:: PMC9371973

Abstract Article PDF–16M

Select item 93485769.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 927928510.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 926261411.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 855165712.

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

Sylvie J. Lavictoire, Danny Jomaa, Alexander Gont, Karen Jardine, David P. Cook, Ian A.J. Lorimer

J Biol Chem. 2021 Nov; 297(5): 101172. Published online 2021 Oct 6. doi: 10.1016/j.jbc.2021.101172

PMCID:: PMC8551657

Abstract Article PDF–4.3M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 752241114.

Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway

Wancheng Qiu, Yanhua Chang, Jing Liu, Xu Yang, Yan Yu, Jiajia Li, Qing Liang, Guangchun Sun

Onco Targets Ther. 2020; 13: 9481–9495. Published online 2020 Sep 24. doi: 10.2147/OTT.S265592

PMCID:: PMC7522411

Abstract Article PDF–8.3M

Select item 747672115.

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding

Sandeep K. Ravala, Jesse B. Hopkins, Caroline B. Plescia, Samantha R. Allgood, Madison A. Kane, Jennifer N. Cash, Robert V. Stahelin, John J. G. Tesmer

J Biol Chem. 2020 Sep 4; 295(36): 12635–12647. Published online 2020 Jul 13. doi: 10.1074/jbc.RA120.014534

PMCID:: PMC7476721

Abstract Article PDF–2.3M

Select item 700738716.

PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells

Miranda E. Clements, Rachelle W. Johnson

Oncogene. Author manuscript; available in PMC 2020 Apr 21.

Published in final edited form as: Oncogene. 2020 Feb; 39(6): 1318–1334. Published online 2019 Oct 21. doi: 10.1038/s41388-019-1064-3

PMCID:: PMC7007387

Abstract Article PDF–3.2M

Select item 679551917.

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Jennifer N. Cash, Sarah Urata, Sheng Li, Sandeep K. Ravala, Larisa V. Avramova, Michael D. Shost, J. Silvio Gutkind, John J. G. Tesmer, Michael A. Cianfrocco

Sci Adv. 2019 Oct; 5(10): eaax8855. Published online 2019 Oct 16. doi: 10.1126/sciadv.aax8855

PMCID:: PMC6795519

Abstract Article PDF–6.7M

Select item 675758318.

Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

Anthony W. Harrington, Ju Young Kim, Sung Ok Yoon

J Neurosci. 2002 Jan 1; 22(1): 156–166. doi: 10.1523/JNEUROSCI.22-01-00156.2002

PMCID:: PMC6757583

Abstract Article PDF–582K

Select item 674682219.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 673800420.

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series

Ying Zhong, Jing Zhang, Yidong Zhou, Feng Mao, Yan Lin, Yali Xu, Jinghong Guan, Songjie Shen, Bo Pan, Changjun Wang, Li Peng, Xin Huang, Yan Li, Xi Cao, Qiang Sun

Med Sci Monit. 2019; 25: 6554–6562. Published online 2019 Sep 1. doi: 10.12659/MSM.915845

PMCID:: PMC6738004

Abstract Article PDF–2.1M

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