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Select item 110870531.

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

F Javier DeHaro-Arbona, Charalambos Roussos, Sarah Baloul, Jonathan Townson, María J Gómez Lamarca, Sarah Bray

eLife. 2024; 12: RP92083. Published online 2024 May 10. doi: 10.7554/eLife.92083

PMCID:: PMC11087053

Abstract Article PDF–6.6M

Select item 103249482.

Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild-caught populations of Drosophila melanogaster

Katie Pelletier, William R Pitchers, Anna Mammel, Emmalee Northrop-Albrecht, Eladio J Márquez, Rosa A Moscarella, David Houle, Ian Dworkin

Genetics. 2023 Jul; 224(3): iyad050. Published online 2023 Mar 24. doi: 10.1093/genetics/iyad050

PMCID:: PMC10324948

Abstract Article PDF–1.0M

Select item 98658083.

Regular Exercise in Drosophila Prevents Age-Related Cardiac Dysfunction Caused by High Fat and Heart-Specific Knockdown of skd

Yurou Cao, Shiyi He, Meng Ding, Wenzhi Gu, Tongquan Wang, Shihu Zhang, Jiadong Feng, Qiufang Li, Lan Zheng

Int J Mol Sci. 2023 Jan; 24(2): 1216. Published online 2023 Jan 7. doi: 10.3390/ijms24021216

PMCID:: PMC9865808

Abstract Article PDF–11M

Select item 97025404.

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila

Xiao Li, Meng Zhang, Mengmeng Liu, Tzu-Hao Liu, Rajitha-Udakara-Sampath Hemba-Waduge, Jun-Yuan Ji

Dis Model Mech. 2022 Nov 1; 15(11): dmm049650. Published online 2022 Nov 14. doi: 10.1242/dmm.049650

PMCID:: PMC9702540

Abstract Article

Select item 91832335.

Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation

Julia Falo-Sanjuan, Sarah Bray

eLife. 2022; 11: e73656. Published online 2022 May 18. doi: 10.7554/eLife.73656

PMCID:: PMC9183233

Abstract Article PDF–7.1M

Select item 89310026.

Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor

Federico Miozzo, Eva P. Valencia-Alarcón, Luca Stickley, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagoshi

Nat Commun. 2022; 13: 1426. Published online 2022 Mar 17. doi: 10.1038/s41467-022-29075-0

PMCID:: PMC8931002

Abstract Article PDF–6.9M

Select item 81895827.

What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes

Nirmalya Chatterjee, Norbert Perrimon

Sci Adv. 2021 Jun; 7(24): eabg4336. Published online 2021 Jun 9. doi: 10.1126/sciadv.abg4336

PMCID:: PMC8189582

Abstract Article PDF–327K

Select item 80696488.

Genetic Screen in Adult Drosophila Reveals That dCBP Depletion in Glial Cells Mitigates Huntington Disease Pathology through a Foxo-Dependent Pathway

Elodie Martin, Raheleh Heidari, Véronique Monnier, Hervé Tricoire

Int J Mol Sci. 2021 Apr; 22(8): 3884. Published online 2021 Apr 9. doi: 10.3390/ijms22083884

PMCID:: PMC8069648

Abstract Article PDF–2.8M

Select item 79772879.

Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens

Chuqin Huang, Rui Xu, Samuel Liégeois, Di Chen, Zi Li, Dominique Ferrandon

Front Immunol. 2020; 11: 478958. Published online 2021 Mar 5. doi: 10.3389/fimmu.2020.478958

PMCID:: PMC7977287

Abstract Article PDF–2.3M

Select item 733264510.

De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay

Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer

Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017

PMCID:: PMC7332645

Abstract Article PDF–1.0M

Select item 728267611.

The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription

Xiao Li, Mengmeng Liu, Xingjie Ren, Nicolas Loncle, Qun Wang, Rajitha-Udakara-Sampath Hemba-Waduge, Stephen H. Yu, Muriel Boube, Henri-Marc G. Bourbon, Jian-Quan Ni, Jun-Yuan Ji

PLoS Genet. 2020 May; 16(5): e1008832. Published online 2020 May 28. doi: 10.1371/journal.pgen.1008832

PMCID:: PMC7282676

Abstract Article PDF–4.0M

Select item 721398112.

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein

eLife. 2020; 9: e53659. Published online 2020 Apr 16. doi: 10.7554/eLife.53659

PMCID:: PMC7213981

Abstract Article PDF–3.4M

Select item 702626813.

A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila

Sébastien Feuillette, Camille Charbonnier, Thierry Frebourg, Dominique Campion, Magalie Lecourtois

Front Neurosci. 2020; 14: 68. Published online 2020 Feb 11. doi: 10.3389/fnins.2020.00068

PMCID:: PMC7026268

Abstract Article PDF–8.7M

Select item 642514414.

Drosophila Mediator Subunit Med1 Is Required for GATA-Dependent Developmental Processes: Divergent Binding Interfaces for Conserved Coactivator Functions

Clément Immarigeon, Sandra Bernat-Fabre, Benoit Augé, Christian Faucher, Vanessa Gobert, Marc Haenlin, Lucas Waltzer, Adeline Payet, David L. Cribbs, Henri-Marc G. Bourbon, Muriel Boube

Mol Cell Biol. 2019 Apr 1; 39(7): e00477-18. Prepublished online 2019 Jan 22. Published online 2019 Mar 19. doi: 10.1128/MCB.00477-18

PMCID:: PMC6425144

Abstract Article PDF–3.5M

Select item 633882715.

Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

Hamutal Arbel, Sumanta Basu, William W. Fisher, Ann S. Hammonds, Kenneth H. Wan, Soo Park, Richard Weiszmann, Benjamin W. Booth, Soile V. Keranen, Clara Henriquez, Omid Shams Solari, Peter J. Bickel, Mark D. Biggin, Susan E. Celniker, James B. Brown

Proc Natl Acad Sci U S A. 2019 Jan 15; 116(3): 900–908. Published online 2018 Dec 31. doi: 10.1073/pnas.1808833115