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Select item 111924701.

ROCK1 is a multifunctional factor maintaining the primordial follicle reserve and follicular development in mice

Tuo Zhang, Huan Lin, Tianhe Ren, Meina He, Wenying Zheng, Yuntong Tong, Bangming Jin, Kaiyun Xie, Ankang Deng, Shiyu Liu, Yuqian Chen, Guoqiang Xu, Tengxiang Chen, Wei Pan, Ziwen Xiao

Am J Physiol Cell Physiol. 2024 Jan 1; 326(1): C27–C39. Published online 2023 Sep 4. doi: 10.1152/ajpcell.00019.2023

PMCID:: PMC11192470

Abstract Article

Select item 111481222.

Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin‐ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki

FEBS Open Bio. 2024 Jun; 14(6): 906–921. Published online 2024 Apr 11. doi: 10.1002/2211-5463.13802

PMCID:: PMC11148122

Abstract Article PDF–12M

Select item 111390343.

Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice

Katerina Mardilovich, Gregory Naylor, Linda Julian, Narisa Phinichkusolchit, Karen Keeshan, Karen Blyth, Michael F. Olson

Dis Model Mech. 2024 May 1; 17(5): dmm050631. Published online 2024 May 21. doi: 10.1242/dmm.050631

PMCID:: PMC11139034

Abstract Article

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108019625.

Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation

Ying Zhang, Nan Li, Sei Kobayashi

Cell Commun Signal. 2024; 22: 58. Published online 2024 Jan 22. doi: 10.1186/s12964-023-01404-w

PMCID:: PMC10801962

Abstract Article PDF–2.0M

Select item 107819526.

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser

Nat Commun. 2024; 15: 446. Published online 2024 Jan 10. doi: 10.1038/s41467-024-44703-7

PMCID:: PMC10781952

Abstract Article PDF–4.3M

Select item 97404217.

Immunogenic Death of Hepatocellular Carcinoma Cells in Mice Expressing Caspase-Resistant ROCK1 Is Not Replicated by ROCK Inhibitors

Gregory Naylor, Linda Julian, Steven Watson-Bryce, Margaret Mullin, Robert J. Nibbs, Michael F. Olson

Cancers (Basel) 2022 Dec; 14(23): 5943. Published online 2022 Nov 30. doi: 10.3390/cancers14235943

PMCID:: PMC9740421

Abstract Article PDF–5.4M

Select item 96493788.

ROCK1 regulates insulin secretion from β-cells

Byung-Jun Sung, Sung-Bin Lim, Won-Mo Yang, Jae Hyeon Kim, Rohit N. Kulkarni, Young-Bum Kim, Moon-Kyu Lee

Mol Metab. 2022 Dec; 66: 101625. Published online 2022 Oct 29. doi: 10.1016/j.molmet.2022.101625

PMCID:: PMC9649378

Abstract Article PDF–2.1M

Select item 90471129.

Vascular Smooth Muscle ROCK1 Contributes to Hypoxia-Induced Pulmonary Hypertension Development in Mice

Krishna C. Penumatsa, Adit A. Singhal, Rod R. Warburton, Michael D. Bear, Chinmayee D. Bhedi, Sabina Nasirova, Jamie L. Wilson, Guanming Qi, Ioana R. Preston, Nicholas S. Hill, Barry L. Fanburg, Young-Bum Kim, Deniz Toksoz

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 May 14.

Published in final edited form as: Biochem Biophys Res Commun. 2022 May 14; 604: 137–143. Published online 2022 Mar 9. doi: 10.1016/j.bbrc.2022.02.064

PMCID:: PMC9047112

Abstract Article PDF–1.0M

Select item 889956610.

Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation

Minghui Li, Xing Lyu, James Liao, Victoria P. Werth, Ming-Lin Liu

Theranostics. 2022; 12(5): 2133–2149. Published online 2022 Feb 7. doi: 10.7150/thno.66457

PMCID:: PMC8899566

Abstract Article PDF–3.2M

Select item 872088111.

The Role of Sorting Nexin 17 in Cardiac Development

Yufei Wu, Yaqun Zhou, Jian Huang, Ke Ma, Tianyou Yuan, Yong Jiang, Maoqing Ye, Jun Li

Front Cardiovasc Med. 2021; 8: 748891. Published online 2021 Dec 20. doi: 10.3389/fcvm.2021.748891

PMCID:: PMC8720881

Abstract Article PDF–9.3M

Select item 864349912.

Loss of Zic3 impairs planar cell polarity leading to abnormal left–right signaling, heart defects and neural tube defects

Helen M Bellchambers, Stephanie M Ware

Hum Mol Genet. 2021 Dec 15; 30(24): 2402–2415. Published online 2021 Jul 19. doi: 10.1093/hmg/ddab195

PMCID:: PMC8643499

Abstract Article PDF–1.3M

Select item 852783613.

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka

Cell. 2021 Sep 30; 184(20): 5089–5106.e21. doi: 10.1016/j.cell.2021.09.007

PMCID:: PMC8527836

Abstract Article

Select item 825704614.

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects

Matthew D. Durbin, James O’Kane, Samuel Lorentz, Anthony B. Firulli, Stephanie M. Ware

Dev Biol. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Dev Biol. 2020 Aug 15; 464(2): 124–136. Published online 2020 Jun 5. doi: 10.1016/j.ydbio.2020.05.013

PMCID:: PMC8257046

Abstract Article PDF–4.9M

Select item 816379015.

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers

NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8

PMCID:: PMC8163790

Abstract Article PDF–6.9M

Select item 808744816.

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Linda Julian, Gregory Naylor, Grant R Wickman, Nicola Rath, Giovanni Castino, David Stevenson, Sheila Bryson, June Munro, Lynn McGarry, Margaret Mullin, Alistair Rice, Armandodel Del Río Hernández, Michael F Olson

eLife. 2021; 10: e61983. Published online 2021 Apr 19. doi: 10.7554/eLife.61983

PMCID:: PMC8087448

Abstract Article PDF–11M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003