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Select item 112297411.

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex

Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei

Epigenetics. 2024; 19(1): 2374979. Published online 2024 Jul 6. doi: 10.1080/15592294.2024.2374979

PMCID:: PMC11229741

Abstract Article PDF–5.0M

Select item 111639622.

Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Wei Li, Li Han, Brandon Tan, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N. Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Jianjun Chen, Xiaolan Deng

Sci Transl Med. Author manuscript; available in PMC 2024 Jun 10.

Published in final edited form as: Sci Transl Med. 2023 Mar 29; 15(689): eabq8513. Published online 2023 Mar 29. doi: 10.1126/scitranslmed.abq8513

PMCID:: PMC11163962

Abstract Article PDF–3.0M

Select item 111535903.

Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation

Xusheng Zhang, Xintong Gao, Zhen Liu, Fei Shao, Dou Yu, Min Zhao, Xiwen Qin, Shuo Wang

Nat Commun. 2024; 15: 4792. Published online 2024 Jun 5. doi: 10.1038/s41467-024-48794-0

PMCID:: PMC11153590

Abstract Article PDF–4.3M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106146825.

Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase

Yu Fan, Yangmian Yuan, Mingrui Xiong, Muchuan Jin, Donge Zhang, Dong Yang, Chengyu Liu, Robert B. Petersen, Kun Huang, Anlin Peng, Ling Zheng

Theranostics. 2023; 13(15): 5348–5364. Published online 2023 Sep 25. doi: 10.7150/thno.87416

PMCID:: PMC10614682

Abstract Article PDF–11M

Select item 105865166.

TET1 and TDG suppress inflammatory response in intestinal tumorigenesis: implications for colorectal tumors with the CpG Island Methylator Phenotype

Rossella Tricarico, Jozef Madzo, Gabrielle Scher, Maya Cohen, Jaroslav Jelinek, Shinji Maegawa, Rajeswari Nagarathinam, Carly Scher, Wen-Chi Chang, Emmanuelle Nicolas, Michael Slifker, Yan Zhou, Karthik Devarajan, Kathy Q. Cai, Tim Kwok, Pamela Nakajima, Jinfei Xu, Pietro Mancuso, Valentina Doneddu, Luigi Bagella, Riley Williams, Siddharth Balachandran, Nicholas Maskalenko, Kerry Campbell, Xueying Ma, Israel Cañadas, Julen Viana, Victor Moreno, Laura Valle, Sergei Grivennikov, Iuliia Peshkova, Natalia Kurilenko, Aleksandra Mazitova, Ekaterina Koltsova, Hayan Lee, Martin Walsh, Reuben Duttweiler, Johnathan R. Whetstine, Timothy J. Yen, Jean-Pierre Issa, Alfonso Bellacosa

Gastroenterology. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gastroenterology. 2023 May; 164(6): 921–936.e1. Published online 2023 Feb 8. doi: 10.1053/j.gastro.2023.01.039

PMCID:: PMC10586516

Abstract Article PDF–3.0M

Select item 105302067.

Role of TET1-mediated epigenetic modulation in Alzheimer’s disease

Matthew J. Armstrong, Yulin Jin, Selina M. Vattathil, Yanting Huang, Jason P. Schroeder, David A. Bennet, Zhaohui S. Qin, Thomas S. Wingo, Peng Jin

Neurobiol Dis. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Neurobiol Dis. 2023 Sep; 185: 106257. Published online 2023 Aug 8. doi: 10.1016/j.nbd.2023.106257

PMCID:: PMC10530206

Abstract Article PDF–1.9M

Select item 102879248.

Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation

Bernard K van der Veer, Lehua Chen, Colin Custers, Paraskevi Athanasouli, Mariana Schroiff, Riet Cornelis, Jonathan Sai-Hong Chui, Richard H Finnell, Frederic Lluis, Kian Peng Koh

Nucleic Acids Res. 2023 Jun 23; 51(11): 5469–5498. Published online 2023 Apr 6. doi: 10.1093/nar/gkad231

PMCID:: PMC10287924

Abstract Article PDF–5.7M

Select item 101573759.

DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

Athmane Teghanemt, Kara Misel‐Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Garima Dixit, Ramasatya Geesala, David K Meyerholz, Thorsten Maretzky, Alejandro Pezzulo, Priya D Issuree

EMBO Rep. 2023 May; 24(5): e55543. Published online 2023 Mar 7. doi: 10.15252/embr.202255543

PMCID:: PMC10157375

Abstract Article PDF–9.7M

Select item 1010326210.

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak

J Am Soc Nephrol. 2023 Apr; 34(4): 572–589. Published online 2022 Dec 15. doi: 10.1681/ASN.2022040460

PMCID:: PMC10103262

Abstract Article

Select item 986459611.

5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues

Adelaida Hernaiz, Sara Sentre, Marina Betancor, Óscar López-Pérez, Mónica Salinas-Pena, Pilar Zaragoza, Juan José Badiola, Janne Markus Toivonen, Rosa Bolea, Inmaculada Martín-Burriel

Int J Mol Sci. 2023 Jan; 24(2): 1621. Published online 2023 Jan 13. doi: 10.3390/ijms24021621

PMCID:: PMC9864596

Abstract Article PDF–7.8M

Select item 983366712.

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

Guo-Dong Chen, Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y. Fessing, Andrei N. Mardaryev, Andrey A. Sharov, Guo-Liang Xu, Vladimir A. Botchkarev

Sci Adv. 2023 Jan; 9(2): eabo7605. Published online 2023 Jan 11. doi: 10.1126/sciadv.abo7605

PMCID:: PMC9833667

Abstract Article PDF–3.1M

Select item 944012213.

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation

María Arroyo, Florian D. Hastert, Andreas Zhadan, Florian Schelter, Susanne Zimbelmann, Cathia Rausch, Anne K. Ludwig, Thomas Carell, M. Cristina Cardoso

Nat Commun. 2022; 13: 5173. Published online 2022 Sep 2. doi: 10.1038/s41467-022-32799-8

Correction in:: Nat Commun. 2023; 14: 369.

PMCID:: PMC9440122

Abstract Article PDF–9.3M

Select item 943242914.

The intrinsic and extrinsic effects of TET proteins during gastrulation

Saifeng Cheng, Markus Mittnenzweig, Yoav Mayshar, Aviezer Lifshitz, Marko Dunjić, Yoach Rais, Raz Ben-Yair, Stephanie Gehrs, Elad Chomsky, Zohar Mukamel, Hernan Rubinstein, Katharina Schlereth, Netta Reines, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzer

Cell. 2022 Aug 18; 185(17): 3169–3185.e20. doi: 10.1016/j.cell.2022.06.049

PMCID:: PMC9432429

Abstract Article

Select item 943213915.

Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways

Cuida Meng, Lei Gu, Yujing Li, Ronghua Li, Yiqu Cao, Ziyi Li, Emily G Allen, Dongdong Zhu, Peng Jin

Hum Mol Genet. 2021 Nov 1; 30(21): 1985–1995. Published online 2021 Jun 24. doi: 10.1093/hmg/ddab167

PMCID:: PMC9432139

Abstract Article PDF–1.3M

Select item 941087716.

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation

Paul Stolz, Angelo Salazar Mantero, Andrey Tvardovskiy, Enes Ugur, Lucas E Wange, Christopher B Mulholland, Yuying Cheng, Michael Wierer, Wolfgang Enard, Robert Schneider, Till Bartke, Heinrich Leonhardt, Simon J Elsässer, Sebastian Bultmann

Nucleic Acids Res. 2022 Aug 26; 50(15): 8491–8511. Published online 2022 Jul 29. doi: 10.1093/nar/gkac642