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Items: 1 to 20 of 68

1.
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation
Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West
Mol Neurodegener. 2024; 19: 47. Published online 2024 Jun 11. doi: 10.1186/s13024-024-00738-4
PMCID:
PMC11167795
AbstractArticlePDF–5.2M
2.
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease
Xueting Wang, Yuqi Xie, Xiaoyang Fan, Xiaomei Wu, Dan Wang, Li Zhu
Alzheimers Res Ther. 2024; 16: 121. Published online 2024 Jun 3. doi: 10.1186/s13195-024-01489-6
PMCID:
PMC11145795
AbstractArticlePDF–20M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yoko Manome, Hisayoshi Oka, Yasuyuki Iguchi, Hirotaka James Okano
Cell Mol Life Sci. 2024 Dec; 81(1): 103. Published online 2024 Feb 27. doi: 10.1007/s00018-024-05123-4
PMCID:
PMC10896810
AbstractArticlePDF–3.8M
5.
Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
Prosenjit Pal, Matthew Taylor, Pui Yiu Lam, Francesca Tonelli, Chloe A. Hecht, Pawel Lis, Raja S. Nirujogi, Toan K. Phung, Wondwossen M. Yeshaw, Ebsy Jaimon, Rotimi Fasimoye, Emily A. Dickie, Melanie Wightman, Thomas Macartney, Suzanne R. Pfeffer, Dario R. Alessi
Sci Adv. 2023 Dec 15; 9(50): eadj1205. Published online 2023 Dec 13. doi: 10.1126/sciadv.adj1205
PMCID:
PMC10848721
AbstractArticlePDF–3.5M
6.
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease
Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore
Mol Neurodegener. 2023; 18: 51. Published online 2023 Aug 4. doi: 10.1186/s13024-023-00641-4
PMCID:
PMC10403858
AbstractArticlePDF–14M
7.
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health
James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen J. Cross, Kate J. Heesom, Wen-Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen
Nat Commun. 2023; 14: 3086. Published online 2023 May 29. doi: 10.1038/s41467-023-38719-8
PMCID:
PMC10227043
AbstractArticlePDF–10M
8.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
9.
Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei, Wen-Cheng Xiong
J Neuroinflammation. 2022; 19: 61. Published online 2022 Mar 2. doi: 10.1186/s12974-022-02422-0
PMCID:
PMC8892702
AbstractArticlePDF–3.2M
10.
The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer’s disease
Yasir H. Qureshi, Diego E. Berman, Samuel E. Marsh, Ronald L. Klein, Vivek M. Patel, Sabrina Simoes, Suvarnambiga Kannan, Gregory A. Petsko, Beth Stevens, Scott A. Small
Cell Rep. Author manuscript; available in PMC 2022 Feb 10.
Published in final edited form as: Cell Rep. 2022 Jan 18; 38(3): 110262. doi: 10.1016/j.celrep.2021.110262
PMCID:
PMC8830374
AbstractArticlePDF–4.2M
11.
Alzheimer’s vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling
Sabrina Simoes, Jia Guo, Luna Buitrago, Yasir H. Qureshi, Xinyang Feng, Milankumar Kothiya, Etty Cortes, Vivek Patel, Suvarnambiga Kannan, Young-Hyun Kim, Kyu-Tae Chang, Alzheimer’s Disease Neuroimaging Initiative, S. Abid Hussaini, Herman Moreno, Gilbert Di Paolo, Olav M. Andersen, Scott A. Small
Cell Rep. Author manuscript; available in PMC 2022 Jan 27.
Published in final edited form as: Cell Rep. 2021 Dec 28; 37(13): 110182. doi: 10.1016/j.celrep.2021.110182
PMCID:
PMC8792909
AbstractArticlePDF–1.7M
12.
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition
Chelsie A. Kadgien, Anusha Kamesh, Austen J. Milnerwood
Mol Brain. 2021; 14: 143. Published online 2021 Sep 16. doi: 10.1186/s13041-021-00848-w
PMCID:
PMC8447518
AbstractArticlePDF–7.5M
13.
Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality
Dorian Sargent, Lindsey A Cunningham, Dylan J Dues, Yue Ma, Jennifer J Kordich, Gabriela Mercado, Patrik Brundin, Rita M Cowell, Darren J Moore
Brain Commun. 2021; 3(3): fcab208. Published online 2021 Sep 10. doi: 10.1093/braincomms/fcab208
PMCID:
PMC8445400
AbstractArticlePDF–2.3M
14.
Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death
Yang Zhao, Fulei Tang, Daehoon Lee, Wen-Cheng Xiong
Int J Mol Sci. 2021 Aug; 22(16): 8394. Published online 2021 Aug 4. doi: 10.3390/ijms22168394
PMCID:
PMC8395035
AbstractArticlePDF–5.0M
15.
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Mengyue Niu, Fanpeng Zhao, Karina Bondelid, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Wenzhang Wang, Jun Liu, Xiongwei Zhu
Aging Cell. 2021 May; 20(5): e13347. Published online 2021 Mar 21. doi: 10.1111/acel.13347
PMCID:
PMC8135078
AbstractArticlePDF–2.8M
16.
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia
Nucleic Acids Res. 2021 Apr 6; 49(6): 3524–3545. Published online 2021 Feb 28. doi: 10.1093/nar/gkab118
PMCID:
PMC8034651
AbstractArticlePDF–7.2M
17.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
18.
Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans
Sabrina Simoes, Jessica L. Neufeld, Gallen Triana-Baltzer, Setareh Moughadam, Emily I. Chen, Milankumar Kothiya, Yasir H. Qureshi, Vivek Patel, Lawrence S. Honig, Hartmuth Kolb, Scott A. Small
Sci Transl Med. Author manuscript; available in PMC 2021 Feb 23.
Published in final edited form as: Sci Transl Med. 2020 Nov 25; 12(571): eaba6334. doi: 10.1126/scitranslmed.aba6334
PMCID:
PMC7901670
AbstractArticlePDF–2.3M
19.
Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zeng
Mol Brain. 2020; 13: 164. Published online 2020 Dec 1. doi: 10.1186/s13041-020-00704-3
PMCID:
PMC7706192
AbstractArticlePDF–3.9M
20.
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model
Ching-Chi Chiu, Yi-Hsin Weng, Ying-Zu Huang, Rou-Shayn Chen, Yu-Chuan Liu, Tu-Hsueh Yeh, Chin-Song Lu, Yan-Wei Lin, Yu-Jie Chen, Chia-Chen Hsu, Chi-Han Chiu, Yu-Ting Wang, Wan-Shia Chen, Shu-Yu Liu, Hung-Li Wang
Cell Death Dis. 2020 Nov; 11(11): 1018. Published online 2020 Nov 30. doi: 10.1038/s41419-020-03228-9
PMCID:
PMC7705022
AbstractArticlePDF–3.2M

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