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Select item 110405051.

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

Madison A. Ward, Janakiram R. Vangala, Hatem Elif Kamber Kaya, Holly A. Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K. Radhakrishnan

J Cell Biol. 2024 Jun 3; 223(6): e202306150. Published online 2024 Apr 24. doi: 10.1083/jcb.202306150

PMCID:: PMC11040505

Abstract Article PDF–6.2M

Select item 106812262.

Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells

Keli Liu, Shaofan Hu, Lu Qiu, Meng Wang, Zhengwen Zhang, Guiyin Sun, Yiguo Zhang

PLoS One. 2023; 18(11): e0294508. Published online 2023 Nov 27. doi: 10.1371/journal.pone.0294508

PMCID:: PMC10681226

Abstract Article PDF–3.7M

Select item 105169263.

Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer

Holly A. Byers, Amy N. Brooks, Janakiram R. Vangala, Jacqueline M. Grible, Alex Feygin, Charles V. Clevenger, J. Chuck Harrell, Senthil K. Radhakrishnan

Sci Rep. 2023; 13: 15843. Published online 2023 Sep 22. doi: 10.1038/s41598-023-43121-x

PMCID:: PMC10516926

Abstract Article PDF–2.3M

Select item 104872384.

Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage

Mustafa Elshani, In Hwa Um, Steve Leung, Paul A. Reynolds, Alex Chapman, Mary Kudsy, David J. Harrison

Cells. 2023 Sep; 12(17): 2165. Published online 2023 Aug 29. doi: 10.3390/cells12172165

PMCID:: PMC10487238

Abstract Article PDF–3.3M

Select item 104741565.

The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi

Sci Rep. 2023; 13: 14405. Published online 2023 Sep 1. doi: 10.1038/s41598-023-41492-9

PMCID:: PMC10474156

Abstract Article PDF–2.8M

Select item 104045586.

Unravelling the role of NFE2L1 in stress responses and related diseases

Xingzhu Liu, Chang Xu, Wanglong Xiao, Nianlong Yan

Redox Biol. 2023 Sep; 65: 102819. Published online 2023 Jul 14. doi: 10.1016/j.redox.2023.102819

PMCID:: PMC10404558

Abstract Article PDF–3.4M

Select item 103126747.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 100848098.

Induction of Herpud1 expression by ER stress is regulated by Nrf1

Daniel V. Ho, Jefferson Y. Chan

FEBS Lett. Author manuscript; available in PMC 2023 Apr 10.

Published in final edited form as: FEBS Lett. 2015 Feb 27; 589(5): 615–620. Published online 2015 Jan 28. doi: 10.1016/j.febslet.2015.01.026

PMCID:: PMC10084809

Abstract Article PDF–2.0M

Select item 95128019.

A dual Keap1 and p47^phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun

Cell Death Dis. 2022 Sep; 13(9): 824. Published online 2022 Sep 26. doi: 10.1038/s41419-022-05274-x

PMCID:: PMC9512801

Abstract Article PDF–6.7M

Select item 896036710.

A novel nonsense variant in the NFE2L1 transcription factor in a patient with developmental delay, hypotonia, genital anomalies and failure to thrive

Julia M. Wang, Daniel V. Ho, Amy Kritzer, Jefferson Y. Chan

Hum Mutat. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Hum Mutat. 2022 Apr; 43(4): 471–476. Published online 2022 Feb 7. doi: 10.1002/humu.24337

PMCID:: PMC8960367

Abstract Article PDF–434K

Select item 893137111.

Ferroptosis regulation by the NGLY1/NFE2L1 pathway

Giovanni C. Forcina, Lauren Pope, Magdalena Murray, Wentao Dong, Monther Abu-Remaileh, Carolyn R. Bertozzi, Scott J. Dixon

Proc Natl Acad Sci U S A. 2022 Mar 15; 119(11): e2118646119. Published online 2022 Mar 10. doi: 10.1073/pnas.2118646119

PMCID:: PMC8931371

Abstract Article PDF–1.4M

Select item 879158012.

Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival

Tianzeng Chen, Matthew Ho, Jenna Briere, Maria Moscvin, Peter G. Czarnecki, Kenneth C. Anderson, T. Keith Blackwell, Giada Bianchi

Blood Adv. 2022 Jan 25; 6(2): 429–440. Published online 2022 Jan 17. doi: 10.1182/bloodadvances.2020003820

PMCID:: PMC8791580

Abstract Article PDF–1.7M

Select item 876907213.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 842138614.

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Miao Cui, Ayhan Atmanli, Maria Gabriela Morales, Wei Tan, Kenian Chen, Xue Xiao, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson

Nat Commun. 2021; 12: 5270. Published online 2021 Sep 6. doi: 10.1038/s41467-021-25653-w

PMCID:: PMC8421386

Abstract Article PDF–4.6M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 816397416.

The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure

John J.W. Han, Daniel V. Ho, Hyun M. Kim, Jun Y. Lee, Yerin S. Jeon, Jefferson Y. Chan

J Biol Chem. 2021 Jan-Jun; 296: 100732. Published online 2021 Apr 30. doi: 10.1016/j.jbc.2021.100732

PMCID:: PMC8163974

Abstract Article PDF–1.8M

Select item 774418617.

Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks

Shuwei Zhang, Yangxu Deng, Yuancai Xiang, Shaofan Hu, Lu Qiu, Yiguo Zhang

Oxid Med Cell Longev. 2020; 2020: 5097109. Published online 2020 Nov 16. doi: 10.1155/2020/5097109

PMCID:: PMC7744186

Abstract Article PDF–6.1M

Select item 755069518.

Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration

Amy Northrop, Holly A. Byers, Senthil K. Radhakrishnan

Mol Biol Cell. 2020 Sep 15; 31(20): 2158–2163. doi: 10.1091/mbc.E20-04-0238

PMCID:: PMC7550695

Abstract Article PDF–321K

Select item 736963619.

DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1

A. Barbara Dirac-Svejstrup, Jane Walker, Peter Faull, Vesela Encheva, Vyacheslav Akimov, Michele Puglia, David Perkins, Sandra Kümper, Suchete S. Hunjan, Blagoy Blagoev, Ambrosius P. Snijders, David J. Powell, Jesper Q. Svejstrup

Mol Cell. 2020 Jul 16; 79(2): 332–341.e7. doi: 10.1016/j.molcel.2020.05.035

PMCID:: PMC7369636

Abstract Article

Select item 732484920.

NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression

Tsuyoshi Waku, Hiroyuki Katayama, Miyako Hiraoka, Atsushi Hatanaka, Nanami Nakamura, Yuya Tanaka, Natsuko Tamura, Akira Watanabe, Akira Kobayashi

Mol Cell Biol. 2020 Jul; 40(14): e00010-20. Prepublished online 2020 May 4. Published online 2020 Jun 29. doi: 10.1128/MCB.00010-20

PMCID:: PMC7324849

Abstract Article PDF–2.1M

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