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Items: 1 to 20 of 44

1.
Solution Ionic Strength Can Modulate Functional Loop Conformations in E. coli Dihydrofolate Reductase
C. Satheesan Babu, Jih-Ying Chen, Carmay Lim
J Phys Chem B. 2024 May 2; 128(17): 4111–4122. Published online 2024 Apr 23. doi: 10.1021/acs.jpcb.4c00677
PMCID:
PMC11075089
AbstractArticlePDF–3.8M
2.
DHFR Mutants Modulate Their Synchronized Dynamics with the Substrate by Shifting Hydrogen Bond Occupancies
Ebru Cetin, Ali Rana Atilgan, Canan Atilgan
J Chem Inf Model. 2022 Dec 26; 62(24): 6715–6726. Published online 2022 Aug 19. doi: 10.1021/acs.jcim.2c00507
PMCID:
PMC9795552
AbstractArticlePDF–4.2M
3.
Protein Interface Remodeling in a Chemically Induced Protein Dimer
Brian R. White, Jonathan C.T. Carlson, Jessie L. Kerns, Carston R. Wagner
J Mol Recognit. Author manuscript; available in PMC 2017 Aug 23.
Published in final edited form as: J Mol Recognit. 2012 Jul; 25(7): 393–403. doi: 10.1002/jmr.2196
PMCID:
PMC5568899
AbstractArticlePDF–1.0M
4.
The relationship between chain connectivity and domain stability in the equilibrium and kinetic folding mechanisms of dihydrofolate reductase from E.coli
Anna-Karin E. Svensson, Jill A. Zitzewitz, C.Robert Matthews, Virginia F. Smith
Protein Eng Des Sel. 2006 Apr; 19(4): 175–185. Published online 2006 Feb 1. doi: 10.1093/protein/gzj017
PMCID:
PMC5441858
AbstractArticlePDF–651K
5.
Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway
David Oyen, R. Bryn Fenwick, Robyn L. Stanfield, H. Jane Dyson, Peter E. Wright
J Am Chem Soc. 2015 Jul 29; 137(29): 9459–9468. Published online 2015 Jul 6. doi: 10.1021/jacs.5b05707
PMCID:
PMC4521799
AbstractArticlePDF–2.9M
6.
Ligand binding to a high-energy partially unfolded protein
Joseph R Kasper, Chiwook Park
Protein Sci. 2015 Jan; 24(1): 129–137. Published online 2014 Nov 4. doi: 10.1002/pro.2596
PMCID:
PMC4282418
AbstractArticlePDF–315K
7.
The binary protein-protein interaction landscape of Escherichia coli
Seesandra V. Rajagopala, Patricia Sikorski, Ashwani Kumar, Roberto Mosca, James Vlasblom, Roland Arnold, Jonathan Franca-Koh, Suman B. Pakala, Sadhna Phanse, Arnaud Ceol, Roman Häuser, Gabriella Siszler, Stefan Wuchty, Andrew Emili, Mohan Babu, Patrick Aloy, Rembert Pieper, Peter Uetz
Nat Biotechnol. Author manuscript; available in PMC 2014 Sep 1.
Published in final edited form as: Nat Biotechnol. 2014 Mar; 32(3): 285–290. Published online 2014 Feb 23. doi: 10.1038/nbt.2831
PMCID:
PMC4123855
AbstractArticlePDF–1.1M
8.
Side-Chain Conformational Heterogeneity of Intermediates in the Escherichia coli Dihydrofolate Reductase Catalytic Cycle
Lisa M. Tuttle, H. Jane Dyson, Peter E. Wright
Biochemistry. Author manuscript; available in PMC 2014 May 21.
Published in final edited form as: Biochemistry. 2013 May 21; 52(20): 10.1021/bi400322e. Published online 2013 May 7. doi: 10.1021/bi400322e
PMCID:
PMC3796204
AbstractArticlePDF–5.0M
9.
Connecting Protein Conformational Dynamics with Catalytic Function as Illustrated in Dihydrofolate Reductase
Yao Fan, Alessandro Cembran, Shuhua Ma, Jiali Gao
Biochemistry. Author manuscript; available in PMC 2014 Mar 26.
Published in final edited form as: Biochemistry. 2013 Mar 26; 52(12): 10.1021/bi301559q. Published online 2013 Jan 16. doi: 10.1021/bi301559q
PMCID:
PMC3773050
AbstractArticlePDF–5.7M
10.
Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans
C. Tony Liu, Philip Hanoian, Jarrod B. French, Thomas H. Pringle, Sharon Hammes-Schiffer, Stephen J. Benkovic
Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25): 10159–10164. Published online 2013 Jun 3. doi: 10.1073/pnas.1307130110
PMCID:
PMC3690862
AbstractArticlePDF–666K
11.
Flexibility, Diversity, and Cooperativity: Pillars of Enzyme Catalysis
Gordon G. Hammes, Stephen J. Benkovic, Sharon Hammes-Schiffer
Biochemistry. Author manuscript; available in PMC 2012 Dec 6.
Published in final edited form as: Biochemistry. 2011 Dec 6; 50(48): 10422–10430. Published online 2011 Nov 11. doi: 10.1021/bi201486f
PMCID:
PMC3226911
AbstractArticlePDF–1.2M
12.
Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR
Gira Bhabha, Lisa Tuttle, Maria Martinez-Yamout, Peter E. Wright
FEBS Lett. Author manuscript; available in PMC 2012 Nov 16.
Published in final edited form as: FEBS Lett. 2011 Nov 16; 585(22): 3528–3532. Published online 2011 Oct 20. doi: 10.1016/j.febslet.2011.10.014
PMCID:
PMC3215841
AbstractArticlePDF–1.5M
13.
Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein
Olayinka A. Oyeyemi, Kevin M. Sours, Thomas Lee, Amnon Kohen, Katheryn A. Resing, Natalie G. Ahn, Judith P. Klinman
Biochemistry. 2011 Sep 27; 50(38): 8251–8260. Published online 2011 Aug 22. doi: 10.1021/bi200640s
PMCID:
PMC3180199
AbstractArticlePDF–3.1M
14.
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert, Jongsik Gam, Ian A. Wilson, H. Jane Dyson, Stephen J. Benkovic, Peter E. Wright
Science. Author manuscript; available in PMC 2011 Oct 8.
Published in final edited form as: Science. 2011 Apr 8; 332(6026): 234–238. doi: 10.1126/science.1198542
PMCID:
PMC3151171
AbstractArticlePDF–1.8M
15.
Surface Sites for Engineering Allosteric Control in Proteins
Jeeyeon Lee, Madhusudan Natarajan, Vishal C. Nashine, Michael Socolich, Tina Vo, William P. Russ, Stephen J. Benkovic, Rama Ranganathan
Science. Author manuscript; available in PMC 2011 Apr 6.
Published in final edited form as: Science. 2008 Oct 17; 322(5900): 438–442. doi: 10.1126/science.1159052
PMCID:
PMC3071530
AbstractArticlePDF–1.1M
16.
NMR study of the role of M42 in the solution dynamics of E. COLI dihydrofolate reductase
Randall V. Mauldin, Andrew L. Lee
Biochemistry. Author manuscript; available in PMC 2011 Mar 2.
Published in final edited form as: Biochemistry. 2010 Mar 2; 49(8): 1606–1615. doi: 10.1021/bi901798g
PMCID:
PMC2872547
AbstractArticlePDF–1.1M
17.
Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands
David D. Boehr, Dan McElheny, H. Jane Dyson, Peter E. Wright
Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4): 1373–1378. Published online 2010 Jan 8. doi: 10.1073/pnas.0914163107
PMCID:
PMC2824364
AbstractArticlePDF–734K
18.
The Decay of the Chromosomally Encoded ccdO157 Toxin–Antitoxin System in the Escherichia coli Species
Natacha Mine, Julien Guglielmini, Myriam Wilbaux, Laurence Van Melderen
Genetics. 2009 Apr; 181(4): 1557–1566. doi: 10.1534/genetics.108.095190
PMCID:
PMC2666520
AbstractArticlePDF–448K
19.
Computational Approach for Ranking Mutant Enzymes According to Catalytic Reaction Rates
Malika Kumarasiri, Gregory A. Baker, Alexander V. Soudackov, Sharon Hammes-Schiffer
J Phys Chem B. Author manuscript; available in PMC 2010 Mar 19.
Published in final edited form as: J Phys Chem B. 2009 Mar 19; 113(11): 3579–3583. doi: 10.1021/jp810363k
PMCID:
PMC2664535
AbstractArticlePDF–1.1M
20.
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis
David D. Boehr, H. Jane Dyson, Peter E. Wright
Biochemistry. Author manuscript; available in PMC 2009 Sep 2.
Published in final edited form as: Biochemistry. 2008 Sep 2; 47(35): 9227–9233. Published online 2008 Aug 9. doi: 10.1021/bi801102e
PMCID:
PMC2562322
AbstractArticlePDF–1.6M

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