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Select item 107617301.

Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration

Fan Chen, Linchuan Lei, Shunlun Chen, Zhuoyang Zhao, Yuming Huang, Guowei Jiang, Xingyu Guo, Zemin Li, Zhaomin Zheng, Jianru Wang

Nat Commun. 2024; 15: 47. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44313-9

PMCID:: PMC10761730

Abstract Article PDF–9.6M

Select item 88266202.

SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1–Negative Lung Adenocarcinomas

Ichidai Tanaka, Delphine Dayde, Mei Chee Tai, Haruki Mori, Luisa M Solis, Satyendra C Tripathi, Johannes F Fahrmann, Nese Unver, Gargy Parhy, Rekha Jain, Edwin R Parra, Yoshiko Murakami, Clemente Aguilar-Bonavides, Barbara Mino, Muge Celiktas, Dilsher Dhillon, Julian Phillip Casabar, Masahiro Nakatochi, Francesco Stingo, Veera Baladandayuthapani, Hong Wang, Hiroyuki Katayama, Jennifer B Dennison, Philip L Lorenzi, Kim-Anh Do, Junya Fujimoto, Carmen Behrens, Edwin J Ostrin, Jaime Rodriguez-Canales, Tetsunari Hase, Takayuki Fukui, Taisuke Kajino, Seiichi Kato, Yasushi Yatabe, Waki Hosoda, Koji Kawaguchi, Kohei Yokoi, Toyofumi F Chen-Yoshikawa, Yoshinori Hasegawa, Adi F Gazdar, Ignacio I Wistuba, Samir Hanash, Ayumu Taguchi

J Natl Cancer Inst. 2022 Feb; 114(2): 290–301. Published online 2021 Sep 15. doi: 10.1093/jnci/djab183

PMCID:: PMC8826620

Abstract Article PDF–2.5M

Select item 84607283.

Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

Yunfei He, Dongdong Cheng, Cheng Lian, Yingjie Liu, Wenqian Luo, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Xue Zhang, Zhen Pan, Jinxi Lu, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Qingcheng Yang, Guohong Hu

Cell Death Dis. 2021 Oct; 12(10): 868. Published online 2021 Sep 23. doi: 10.1038/s41419-021-04161-1

PMCID:: PMC8460728

Abstract Article PDF–4.9M

Select item 79579734.

The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy

Layi Wang, Yin Han, Xiajun Wang

J Clin Lab Anal. 2021 Mar; 35(3): e23663. Published online 2020 Dec 12. doi: 10.1002/jcla.23663

PMCID:: PMC7957973

Abstract Article PDF–1006K

Select item 78513555.

The autoregulatory serglycin/CD44 axis drives stemness‐like phenotypes in TNBC in a β‐catenin‐dependent manner

Li Cao, Fei‐Fei Luo, Hong‐Bin Huang, Tie‐Jun Huang, Hao Hu, Li‐Sheng Zheng, Jing Wang, Li‐Xia Peng, Chao‐Nan Qian, Bi‐Jun Huang

Clin Transl Med. 2021 Feb; 11(2): e311. Published online 2021 Feb 1. doi: 10.1002/ctm2.311

PMCID:: PMC7851355

Article PDF–9.2M

Select item 72017636.

The role of SRGN in the survival and immune infiltrates of skin cutaneous melanoma (SKCM) and SKCM-metastasis patients

Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li, Kun Zhang

BMC Cancer. 2020; 20: 378. Published online 2020 May 5. doi: 10.1186/s12885-020-06849-7

PMCID:: PMC7201763

Abstract Article PDF–2.4M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 71504938.

SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression

Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng

Theranostics. 2020; 10(10): 4290–4307. Published online 2020 Mar 4. doi: 10.7150/thno.41008

PMCID:: PMC7150493

Abstract Article PDF–3.4M

Select item 69393409.

Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44

Jing-You Guo, Chu-Hsuan Chiu, Mei-Jung Wang, Fu-An Li, Jeou-Yuan Chen

J Biomed Sci. 2020; 27: 2. Published online 2020 Jan 2. doi: 10.1186/s12929-019-0600-3

PMCID:: PMC6939340

Abstract Article PDF–2.7M

Select item 541594610.

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner

J-Y Guo, H-S Hsu, S-W Tyan, F-Y Li, J-Y Shew, W-H Lee, J-Y Chen

Oncogene. 2017 Apr 27; 36(17): 2457–2471. Published online 2016 Nov 7. doi: 10.1038/onc.2016.404

PMCID:: PMC5415946

Abstract Article PDF–5.2M

Select item 526088611.

Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis

Qiaoqiao Chu, Hongbing Huang, Tiejun Huang, Li Cao, Lixia Peng, Simei Shi, Lisheng Zheng, Liang Xu, Shijun Zhang, Jialing Huang, Xinjian Li, Chaonan Qian, Bijun Huang

Cell Death Dis. 2016 Nov; 7(11): e2456. Published online 2016 Nov 3. doi: 10.1038/cddis.2016.287

PMCID:: PMC5260886

Abstract Article PDF–4.0M

Select item 468788812.

Serglycin in Quiescent and Proliferating Primary Endothelial Cells

Trine M. Reine, Tram T. Vuong, Arkady Rutkovskiy, Astri J. Meen, Jarle Vaage, Trond G. Jenssen, Svein O. Kolset

PLoS One. 2015; 10(12): e0145584. Published online 2015 Dec 22. doi: 10.1371/journal.pone.0145584

PMCID:: PMC4687888

Abstract Article PDF–2.6M

Select item 463708213.

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

Angeliki Korpetinou, Dionysios J. Papachristou, Angeliki Lampropoulou, Panagiotis Bouris, Vassiliki T. Labropoulou, Argyrios Noulas, Nikos K. Karamanos, Achilleas D. Theocharis

Biomed Res Int. 2015; 2015: 690721. Published online 2015 Oct 25. doi: 10.1155/2015/690721

PMCID:: PMC4637082

Abstract Article PDF–7.3M

Select item 426658814.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 393762615.

Serglycin Proteoglycan Is Required for Multiple Myeloma Cell Adhesion, in Vivo Growth, and Vascularization

Anurag Purushothaman, Bryan P. Toole

J Biol Chem. 2014 Feb 28; 289(9): 5499–5509. Published online 2014 Jan 8. doi: 10.1074/jbc.M113.532143

PMCID:: PMC3937626

Abstract Article PDF–1.7M

Select item 374932616.

Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies

M. Geoffrey Hayes, Margrit Urbanek, Marie-France Hivert, Loren L. Armstrong, Jean Morrison, Cong Guo, Lynn P. Lowe, Douglas A. Scheftner, Anna Pluzhnikov, David M. Levine, Caitlin P. McHugh, Christine M. Ackerman, Luigi Bouchard, Diane Brisson, Brian T. Layden, Daniel Mirel, Kimberly F. Doheny, Marysa V. Leya, Rachel N. Lown-Hecht, Alan R. Dyer, Boyd E. Metzger, Timothy E. Reddy, Nancy J. Cox, William L. Lowe, Jr., for the HAPO Study Cooperative Research Group

Diabetes. 2013 Sep; 62(9): 3282–3291. Published online 2013 Aug 15. doi: 10.2337/db12-1692

Correction in:: Diabetes. 2013 Oct; 62(10): 3641.

PMCID:: PMC3749326

Abstract Article PDF–1.0M

Select item 318838817.

Leveraging the power of next-generation sequencing to generate interactome datasets

Haiyuan Yu, Leah Tardivo, Stanley Tam, Evan Weiner, Fana Gebreab, Changyu Fan, Nenad Svrzikapa, Tomoko Hirozane-Kishikawa, Edward Rietman, Xinping Yang, Julie Sahalie, Kourosh Salehi-Ashtiani, Tong Hao, Michael E. Cusick, David E. Hill, Frederick P. Roth, Pascal Braun, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Methods. 2011 Jun; 8(6): 478–480. Published online 2011 Apr 24. doi: 10.1038/nmeth.1597

PMCID:: PMC3188388

Abstract Article PDF–932K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302475919.

Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GROα/CXCL1

Astri J. Meen, Inger Øynebråten, Trine M. Reine, Annette Duelli, Katja Svennevig, Gunnar Pejler, Trond Jenssen, Svein O. Kolset

J Biol Chem. 2011 Jan 28; 286(4): 2636–2647. Published online 2010 Nov 12. doi: 10.1074/jbc.M110.151944

PMCID:: PMC3024759

Abstract Article PDF–4.2M

Select item 115268820.

Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex.

M N Hatton, R E Loomis, M J Levine, L A Tabak

Biochem J. 1985 Sep 15; 230(3): 817–820. doi: 10.1042/bj2300817

PMCID:: PMC1152688

Summary Page Browse PDF–496K

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