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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103735032.

Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

Hong Gao, Ke Wang, Jorge A. Suarez, Zhongmou Jin, Karina Cunha e Rocha, Dinghong Zhang, Andrea Farrell, Tyler Truong, Yasemin Tekin, Breanna Tan, Hyun Suh Jung, Julia Kempf, Sushil K. Mahata, Wolfgang H. Dillmann, Jorge Suarez, Wei Ying

Front Immunol. 2023; 14: 1216344. Published online 2023 Jul 13. doi: 10.3389/fimmu.2023.1216344

PMCID:: PMC10373503

Abstract Article PDF–5.9M

Select item 102266803.

Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

Jessica Spring, Aly A. Khan, Sophie Lara, Kelly O’Grady, Jessica Wilks, Sandeep Gurbuxani, Steven Erickson, Michael Fischbach, Amy Jacobson, Alexander Chervonsky, Tatyana Golovkina

Cell Rep. Author manuscript; available in PMC 2023 May 29.

Published in final edited form as: Cell Rep. 2022 Sep 13; 40(11): 111341. doi: 10.1016/j.celrep.2022.111341

PMCID:: PMC10226680

Abstract Article PDF–1.1M

Select item 101577274.

Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction

Yan Wang, Yu Zhang, Jiao Li, Chaofu Li, Ranzun Zhao, Changyin Shen, Weiwei Liu, Jidong Rong, Zhenglong Wang, Junbo Ge, Bei Shi

Theranostics. 2023; 13(7): 2192–2209. Published online 2023 Apr 2. doi: 10.7150/thno.78736

PMCID:: PMC10157727

Abstract Article PDF–12M

Select item 101049065.

In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis

Wei Liu, Xia Zhou, Qi Yao, Chen Chen, Qing Zhang, Keshuo Ding, Lu Li, Zhutian Zeng

J Clin Invest. 2023 Apr 17; 133(8): e157937. Published online 2023 Apr 17. doi: 10.1172/JCI157937

PMCID:: PMC10104906

Abstract Article PDF–21M

Select item 96916546.

Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes

Matthew A. Liu, Shandy Shahabi, Suborno Jati, Kechun Tang, Hong Gao, Zhongmou Jin, Wyatt Miller, Frédéric A. Meunier, Wei Ying, Geert van den Bogaart, Gourisankar Ghosh, Sushil K. Mahata

Front Endocrinol (Lausanne) 2022; 13: 1037465. Published online 2022 Nov 11. doi: 10.3389/fendo.2022.1037465

PMCID:: PMC9691654

Abstract Article PDF–19M

Select item 89087917.

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John Leong, Jan-Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing-Ren Zhang

J Exp Med. 2022 Apr 4; 219(4): e20212032. Published online 2022 Mar 8. doi: 10.1084/jem.20212032

PMCID:: PMC8908791

Abstract Article PDF–8.0M

Select item 86608158.

CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

Yi Duan, Huikuan Chu, Katharina Brandl, Lu Jiang, Suling Zeng, Nairika Meshgin, Eleni Papachristoforou, Josepmaria Argemi, Beatriz G. Mendes, Yanhan Wang, Hua Su, Weizhong Sun, Cristina Llorente, Tim Hendrikx, Xiao Liu, Mojgan Hosseini, Tatiana Kisseleva, David A. Brenner, Ramon Bataller, Prakash Ramachandran, Michael Karin, Wenxian Fu, Bernd Schnabl

Nat Commun. 2021; 12: 7172. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27385-3

PMCID:: PMC8660815

Abstract Article PDF–2.5M

Select item 81398699.

VSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-α in a CLP-induced sepsis model resulting in thymic atrophy

Hae-Yun Cho, Yun Gyeong Yang, Youkyoung Jeon, Chae-Kwan Lee, InHak Choi, Soo-Woong Lee

Cell Death Dis. 2021 Jun; 12(6): 526. Published online 2021 May 22. doi: 10.1038/s41419-021-03806-5

PMCID:: PMC8139869

Abstract Article PDF–4.0M

Select item 757624110.

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue

Brandon M. Hall, Anatoli S. Gleiberman, Evguenia Strom, Peter A. Krasnov, David Frescas, Slavoljub Vujcic, Olga V. Leontieva, Marina P. Antoch, Valeria Kogan, Igor E. Koman, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Olga B. Chernova, Andrei V. Gudkov

Aging Cell. 2020 Oct; 19(10): e13219. Published online 2020 Aug 28. doi: 10.1111/acel.13219

PMCID:: PMC7576241

Abstract Article PDF–3.3M

Select item 688383911.

CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement

Gongguan Liu, Yong Fu, Mohammed Yosri, Yanli Chen, Peng Sun, Jinjun Xu, Mingshun Zhang, Donglei Sun, Ashley B. Strickland, Zachary B. Mackey, Meiqing Shi

Proc Natl Acad Sci U S A. 2019 Nov 26; 116(48): 24214–24220. Published online 2019 Nov 13. doi: 10.1073/pnas.1913443116

PMCID:: PMC6883839

Abstract Article PDF–1.2M

Select item 678344012.

Fungal dissemination is limited by liver macrophage filtration of the blood

Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi

Nat Commun. 2019; 10: 4566. Published online 2019 Oct 8. doi: 10.1038/s41467-019-12381-5

PMCID:: PMC6783440

Abstract Article PDF–3.1M

Select item 632675213.

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages

Xiaoyong Huang, Zeqing Feng, Yuanzhong Jiang, Jialin Li, Qun Xiang, Sheng Guo, Chengying Yang, Lei Fei, Guoning Guo, Lixin Zheng, Yuzhang Wu, Yongwen Chen

Sci Adv. 2019 Jan; 5(1): eaau7426. Published online 2019 Jan 9. doi: 10.1126/sciadv.aau7426

PMCID:: PMC6326752

Abstract Article PDF–8.8M

Select item 600265714.

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung

Nagaraja Nagre, Xiaofei Cong, César Terrazas, Ian Pepper, John M. Schreiber, Hongyun Fu, Joshua M. Sill, John W. Christman, Abhay R. Satoskar, Xiaoli Zhao

Am J Respir Cell Mol Biol. 2018 Jun; 58(6): 756–766. doi: 10.1165/rcmb.2017-0236OC

PMCID:: PMC6002657

Abstract Article PDF–1.7M

Select item 572872015.

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

Xiaomei Yuan, Bi-Huei Yang, Yi Dong, Asami Yamamura, Wenxian Fu

eLife. 2017; 6: e29540. Published online 2017 Nov 24. doi: 10.7554/eLife.29540

PMCID:: PMC5728720

Abstract Article PDF–2.5M

Select item 567388916.

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

Jialin Li, Bo Diao, Sheng Guo, Xiaoyong Huang, Chengying Yang, Zeqing Feng, Weiming Yan, Qin Ning, Lixin Zheng, Yongwen Chen, Yuzhang Wu

Nat Commun. 2017; 8: 1322. Published online 2017 Nov 6. doi: 10.1038/s41467-017-01327-4

PMCID:: PMC5673889

Abstract Article PDF–3.5M

Select item 508277117.

Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy

Kwang H. Kim, Beom K. Choi, Young H. Kim, Chungyong Han, Ho S. Oh, Don G. Lee, Byoung S. Kwon

Autophagy. 2016; 12(9): 1647–1659. Published online 2016 Jul 20. doi: 10.1080/15548627.2016.1196314

PMCID:: PMC5082771

Abstract Article PDF–1.3M

Select item 396495518.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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