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Select item 105273101.

CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders

Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal

Cells. 2023 Sep; 12(18): 2218. Published online 2023 Sep 6. doi: 10.3390/cells12182218

PMCID:: PMC10527310

Abstract Article PDF–4.0M

Select item 99963682.

Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR

Xiaojing Yang, André A. Weber, Elvira Mennillo, Miles Paszek, Samantha Wong, Sabrina Le, Jia Ying Ashley Teo, Max Chang, Christopher W. Benner, Robert H. Tukey, Shujuan Chen

J Biol Chem. 2023 Mar; 299(3): 102955. Published online 2023 Jan 30. doi: 10.1016/j.jbc.2023.102955

PMCID:: PMC9996368

Abstract Article PDF–2.2M

Select item 94258533.

Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver

Aram Shin, David J Waxman

Toxicol Sci. 2022 Jun; 187(2): 298–310. Published online 2022 Mar 14. doi: 10.1093/toxsci/kfac032

PMCID:: PMC9425853

Abstract Article PDF–778K

Select item 88621174.

CAR directs T cell adaptation to bile acids in the small intestine

Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud

Nature. Author manuscript; available in PMC 2022 Feb 22.

Published in final edited form as: Nature. 2021 May; 593(7857): 147–151. Published online 2021 Apr 7. doi: 10.1038/s41586-021-03421-6

PMCID:: PMC8862117

Abstract Article PDF–4.8M

Select item 77450835.

Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation

André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen, Robert H. Tukey

Drug Metab Dispos. 2021 Jan; 49(1): 12–19. Published online 2021 Jan. doi: 10.1124/dmd.120.000240

PMCID:: PMC7745083

Abstract Article PDF–1018K

Select item 72745256.

Microbial bile acid metabolites modulate gut RORγ⁺ regulatory T cell homeostasis

Xinyang Song, Ximei Sun, Sungwhan F. Oh, Meng Wu, Yanbo Zhang, Wen Zheng, Naama Geva-Zatorsky, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper

Nature. Author manuscript; available in PMC 2020 Jun 5.

Published in final edited form as: Nature. 2020 Jan; 577(7790): 410–415. Published online 2019 Dec 25. doi: 10.1038/s41586-019-1865-0

PMCID:: PMC7274525

Abstract Article PDF–5.1M

Select item 72638437.

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis

Kang Ho Kim, Jong Min Choi, Feng Li, Armando Arizpe, Clavia Ruth Wooton-Kee, Sayeepriyadarshini Anakk, Sung Yun Jung, Milton J Finegold, David D Moore

Endocrinology. 2018 Jun; 159(6): 2435–2446. Published online 2018 Apr 26. doi: 10.1210/en.2018-00110

PMCID:: PMC7263843

Abstract Article

Select item 70812548.

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver

MyeongJin Yi, Muluneh Fashe, Shingo Arakawa, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi

Sci Rep. 2020; 10: 5001. Published online 2020 Mar 19. doi: 10.1038/s41598-020-61767-9

PMCID:: PMC7081254

Abstract Article PDF–2.4M

Select item 69347549.

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Céline Lukowicz, Sandrine Ellero-Simatos, Marion Régnier, Fabiana Oliviero, Frédéric Lasserre, Arnaud Polizzi, Alexandra Montagner, Sarra Smati, Frédéric Boudou, Françoise Lenfant, Laurence Guzylack-Pirou, Sandrine Menard, Sharon Barretto, Anne Fougerat, Yannick Lippi, Claire Naylies, Justine Bertrand-Michel, Afifa Ait Belgnaoui, Vassilia Theodorou, Nicola Marchi, Pierre Gourdy, Laurence Gamet-Payrastre, Nicolas Loiseau, Hervé Guillou, Laïla Mselli-Lakhal

Sci Rep. 2019; 9: 20169. Published online 2019 Dec 27. doi: 10.1038/s41598-019-56570-0

Correction in:: Sci Rep. 2020; 10: 4256.

PMCID:: PMC6934754

Abstract Article PDF–6.9M

Select item 685848410.

Dual Roles of mTOR in Regulating Liver Injury and Tumorigenesis in Autophagy Defective Mouse Liver

Hong-Min Ni, Xiaojuan Chao, Hua Yang, Fengyan Deng, Shaogui Wang, Qingyun Bai, Hui Qian, Yue Cui, Wei Cui, Yinghong Shi, Wei-Xing Zong, Zhengtao Wang, Li Yang, Wen-Xing Ding

Hepatology. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Hepatology. 2019 Dec; 70(6): 2142–2155. Published online 2019 Jun 24. doi: 10.1002/hep.30770

PMCID:: PMC6858484

Abstract Article PDF–3.3M

Select item 680504311.

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Fengming Chen, Denise M. Coslo, Tao Chen, Limin Zhang, Yuan Tian, Philip B. Smith, Andrew D. Patterson, Curtis J. Omiecinski

J Proteome Res. 2019 Jan 4; 18(1): 239–251. Published online 2018 Oct 18. doi: 10.1021/acs.jproteome.8b00566

PMCID:: PMC6805043

Abstract Article PDF–3.2M

Select item 650538012.

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley, C.R. Wolf

Drug Metab Dispos. 2019 Jun; 47(6): 601–615. Published online 2019 Jun. doi: 10.1124/dmd.119.086397

PMCID:: PMC6505380

Abstract Article PDF–1.7M

Select item 638299613.

Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver

Joseph L. Dempsey, Julia Yue Cui

Drug Metab Dispos. 2019 Mar; 47(3): 329–339. Published online 2019 Mar. doi: 10.1124/dmd.118.085142

PMCID:: PMC6382996

Abstract Article PDF–1.0M

Select item 631001414.

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

Baddreddine Boussadia, Giuseppe Gangarossa, Laila Mselli-Lakhal, Marie-Claude Rousset, Frederic de Bock, Frederic Lassere, Chaitali Ghosh, Jean-Marc Pascussi, Damir Janigro, Nicola Marchi

Exp Neurol. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: Exp Neurol. 2016 Sep; 283(Pt A): 39–48. Published online 2016 May 27. doi: 10.1016/j.expneurol.2016.05.018

PMCID:: PMC6310014

Abstract Article PDF–1.8M

Select item 614479915.

In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

Ben Niu, Denise M Coslo, Alain R Bataille, Istvan Albert, B Franklin Pugh, Curtis J Omiecinski

Nucleic Acids Res. 2018 Sep 19; 46(16): 8385–8403. Published online 2018 Aug 8. doi: 10.1093/nar/gky692

PMCID:: PMC6144799

Abstract Article PDF–7.7M

Select item 603245916.

Transcription Coactivator PRIP, the Peroxisome Proliferator-Activated Receptor (PPAR)-Interacting Protein, Is Redundant for the Function of Nuclear Receptors PPARα and CAR, the Constitutive Androstane Receptor, in Mouse Liver

Joy Sarkar, Chao Qi, Dongsheng Guo, Mohamed R. Ahmed, Yuzhi Jia, Nobuteru Usuda, Navin Viswakarma, M. Sambasiva Rao, Janardan K. Reddy

Gene Expr. 2007; 13(4-5): 255–269. Published online 2018 Jul 5. doi: 10.3727/000000006780666948

PMCID:: PMC6032459

Abstract Article PDF–482K

Select item 586354617.

LATS1 and LATS2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ

Jing Yi, Li Lu, Kilangsungla Yanger, Wenqi Wang, Bo Hwa Sohn, Ben Z. Stanger, Min Zhang, James F. Martin, Jaffer A. Ajani, Junjie Chen, Ju-Seog Lee, Shumei Song, Randy L. Johnson

Hepatology. Author manuscript; available in PMC 2018 Mar 22.

Published in final edited form as: Hepatology. 2016 Nov; 64(5): 1757–1772. Published online 2016 Sep 30. doi: 10.1002/hep.28768

PMCID:: PMC5863546

Abstract Article PDF–873K

Select item 583727518.

Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver

Nicholas J. Lodato, Tisha Melia, Andy Rampersaud, David J. Waxman

Toxicol Sci. 2017 Sep; 159(1): 25–41. Published online 2017 Jul 6. doi: 10.1093/toxsci/kfx114

PMCID:: PMC5837275

Abstract Article PDF–1.8M

Select item 580155619.

Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion–Induced Kidney and Liver Injury

You-Jin Choi, Dong Zhou, Anne Caroline S. Barbosa, Yongdong Niu, Xiudong Guan, Meishu Xu, Songrong Ren, Thomas D. Nolin, Youhua Liu, Wen Xie

Mol Pharmacol. 2018 Mar; 93(3): 239–250. Published online 2018 Mar. doi: 10.1124/mol.117.111146

PMCID:: PMC5801556

Abstract Article PDF–2.5M

Select item 569523520.

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

Nicole M. Kettner, Horatio Voicu, Milton J Finegold, Cristian Coarfa, Arun Sreekumar, Nagireddy Putluri, Chinenye A. Katchy, Choogon Lee, David D. Moore, Loning Fu

Cancer Cell. Author manuscript; available in PMC 2017 Dec 12.

Published in final edited form as: Cancer Cell. 2016 Dec 12; 30(6): 909–924. Published online 2016 Nov 23. doi: 10.1016/j.ccell.2016.10.007

PMCID:: PMC5695235

Abstract Article PDF–4.2M

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