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Items: 1 to 20 of 27

1.
Chronically elevated branched chain amino acid levels are pro-arrhythmic
Vincent Portero, Thomas Nicol, Svitlana Podliesna, Gerard A Marchal, Antonius Baartscheer, Simona Casini, Rafik Tadros, Jorien L Treur, Michael W T Tanck, I Jane Cox, Fay Probert, Tertius A Hough, Sara Falcone, Leander Beekman, Martina Müller-Nurasyid, Gabi Kastenmüller, Christian Gieger, Annette Peters, Stefan Kääb, Moritz F Sinner, Andrew Blease, Arie O Verkerk, Connie R Bezzina, Paul K Potter, Carol Ann Remme
Cardiovasc Res. 2022 May; 118(7): 1742–1757. Published online 2021 Jun 17. doi: 10.1093/cvr/cvab207
PMCID:
PMC9215196
AbstractArticlePDF–2.5M
2.
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Nat Commun. 2016; 7: 12444. Published online 2016 Aug 18. doi: 10.1038/ncomms12444
PMCID:
PMC4992138
AbstractArticlePDF–2.2M
3.
Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover
Christopher J. Lynch, Scot R. Kimball, Yuping Xu, Anna C. Salzberg, Yuka Imamura Kawasawa
Physiol Genomics. 2015 Nov; 47(11): 569–580. Published online 2015 Sep 8. doi: 10.1152/physiolgenomics.00055.2015
PMCID:
PMC4629004
AbstractArticle
4.
PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle
Yukino Hatazawa, Miki Tadaishi, Yuta Nagaike, Akihito Morita, Yoshihiro Ogawa, Osamu Ezaki, Takako Takai-Igarashi, Yasuyuki Kitaura, Yoshiharu Shimomura, Yasutomi Kamei, Shinji Miura
PLoS One. 2014; 9(3): e91006. Published online 2014 Mar 17. doi: 10.1371/journal.pone.0091006
PMCID:
PMC3956461
AbstractArticlePDF–1.1M
5.
Adipose transplant for inborn errors of branched chain amino acid metabolism in mice
Heather A. Zimmerman, Kristine C. Olson, Gang Chen, Christopher J. Lynch
Mol Genet Metab. Author manuscript; available in PMC 2014 Mar 17.
Published in final edited form as: Mol Genet Metab. 2013 Aug; 109(4): 345–353. Published online 2013 May 30. doi: 10.1016/j.ymgme.2013.05.010
PMCID:
PMC3955948
AbstractArticlePDF–810K
6.
Oral Leucine Supplementation Is Sensed by the Brain but neither Reduces Food Intake nor Induces an Anorectic Pattern of Gene Expression in the Hypothalamus
Thais T. Zampieri, João A. B. Pedroso, Isadora C. Furigo, Julio Tirapegui, Jose Donato, Jr.
PLoS One. 2013; 8(12): e84094. Published online 2013 Dec 13. doi: 10.1371/journal.pone.0084094
PMCID:
PMC3862776
AbstractArticlePDF–1.5M
7.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
8.
Impaired branched-chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus
Megan N. Purpera, Li Shen, Marzieh Taghavi, Heike Münzberg, Roy J. Martin, Susan M. Hutson, Christopher D. Morrison
J Endocrinol. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as: J Endocrinol. 2012 Jan; 212(1): 85–94. Published online 2011 Oct 3. doi: 10.1530/JOE-11-0270
PMCID:
PMC3350378
AbstractArticlePDF–1.0M
9.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
10.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
11.
BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice
Charles H. Lang, Christopher J. Lynch, Thomas C. Vary
Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3): R935–R944. Published online 2010 Jul 16. doi: 10.1152/ajpregu.00297.2010
PMCID:
PMC2944428
AbstractArticle
12.
Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels
Mark A. Herman, Pengxiang She, Odile D. Peroni, Christopher J. Lynch, Barbara B. Kahn
J Biol Chem. 2010 Apr 9; 285(15): 11348–11356. Published online 2010 Jan 21. doi: 10.1074/jbc.M109.075184
PMCID:
PMC2857013
AbstractArticlePDF–1.2M
13.
Alcohol-Induced IGF-I Resistance Is Ameliorated in Mice Deficient for Mitochondrial Branched-Chain Aminotransferase
Charles H. Lang, Christopher J. Lynch, Thomas C. Vary
J Nutr. 2010 May; 140(5): 932–938. doi: 10.3945/jn.109.120501
PMCID:
PMC2855262
AbstractArticlePDF–910K
14.
Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance
Pengxiang She, Yingsheng Zhou, Zhiyou Zhang, Kathleen Griffin, Kavitha Gowda, Christopher J. Lynch
J Appl Physiol (1985) 2010 Apr; 108(4): 941–949. Published online 2010 Feb 4. doi: 10.1152/japplphysiol.01248.2009
PMCID:
PMC2853195
AbstractArticle
15.
A mitochondrial protein compendium elucidates complex I disease biology
David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha
Cell. Author manuscript; available in PMC 2009 Nov 18.
Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016
PMCID:
PMC2778844
AbstractArticlePDF–1.2M
16.
Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis
William Sewell, Duncan B. Sparrow, Allanceson J. Smith, Dorian M. Gonzalez, Eric F. Rappaport, Sally L. Dunwoodie, Kenro Kusumi
Dev Biol. Author manuscript; available in PMC 2010 May 15.
Published in final edited form as: Dev Biol. 2009 May 15; 329(2): 400–409. Published online 2009 Mar 3. doi: 10.1016/j.ydbio.2009.02.023
PMCID:
PMC2697309
AbstractArticlePDF–4.4M
17.
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
Pengxiang She, Tanya M. Reid, Sarah K. Bronson, Thomas C. Vary, Andras Hajnal, Christopher J Lynch, Susan M. Hutson
Cell Metab. Author manuscript; available in PMC 2009 Jun 9.
Published in final edited form as: Cell Metab. 2007 Sep; 6(3): 181–194. doi: 10.1016/j.cmet.2007.08.003
PMCID:
PMC2693888
AbstractArticlePDF–1.5M
18.
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin
Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108
PMCID:
PMC2556270
AbstractArticlePDF–493K
19.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
20.
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
Jer-Yuarn Wu, Hsiao-Jung Kao, Sing-Chung Li, Robert Stevens, Steven Hillman, David Millington, Yuan-Tsong Chen
J Clin Invest. 2004 Feb 1; 113(3): 434–440. doi: 10.1172/JCI19574
PMCID:
PMC324540
AbstractArticlePDF–1.1M

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