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Select item 111416171.

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis

Nolwenn Samson, Cristina R. Bosoi, Christian Roy, Laurie Turcotte, Laura Tribouillard, Mathilde Mouchiroud, Line Berthiaume, Jocelyn Trottier, Heitor C. G. Silva, Thomas Guerbette, Ana Belén Plata-Gómez, Aurèle Besse-Patin, Alicia Montoni, Nicolò Ilacqua, Jennifer Lamothe, Yemima R. Citron, Yves Gélinas, Stéphane Gobeil, Roberto Zoncu, Alexandre Caron, Mathieu Morissette, Luca Pellegrini, Patrick J. Rochette, Jennifer L. Estall, Alejo Efeyan, Michael Shum, Étienne Audet-Walsh, Olivier Barbier, André Marette, Mathieu Laplante

Sci Adv. 2024 May 31; 10(22): eadk9681. Published online 2024 May 31. doi: 10.1126/sciadv.adk9681

PMCID:: PMC11141617

Abstract Article PDF–5.4M

Select item 109487702.

Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver

Ana Belén Plata-Gómez, Lucía de Prado-Rivas, Alba Sanz, Nerea Deleyto-Seldas, Fernando García, Celia de la Calle Arregui, Camila Silva, Eduardo Caleiras, Osvaldo Graña-Castro, Elena Piñeiro-Yáñez, Joseph Krebs, Luis Leiva-Vega, Javier Muñoz, Ajay Jain, Guadalupe Sabio, Alejo Efeyan

Nat Commun. 2024; 15: 1878. Published online 2024 Mar 18. doi: 10.1038/s41467-024-46032-1

PMCID:: PMC10948770

Abstract Article PDF–4.4M

Select item 107199273.

Reprogramming tumour-associated macrophages to outcompete cancer cells

Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li

Nature. Author manuscript; available in PMC 2023 Dec 14.

Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5

PMCID:: PMC10719927

Abstract Article PDF–5.6M

Select item 94328404.

Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy

Giorgia Di Lorenzo, Francescopaolo Iavarone, Marianna Maddaluno, Ana Belén Plata-Gómez, Simone Aureli, Camila Paz Quezada Meza, Laura Cinque, Alessandro Palma, Alessio Reggio, Carmine Cirillo, Francesca Sacco, Alexandra Stolz, Gennaro Napolitano, Oriano Marin, Lorenzo A. Pinna, Maria Ruzzene, Vittorio Limongelli, Alejo Efeyan, Paolo Grumati, Carmine Settembre

Sci Adv. 2022 Sep; 8(35): eabo1215. Published online 2022 Aug 31. doi: 10.1126/sciadv.abo1215

PMCID:: PMC9432840

Abstract Article PDF–12M

Select item 82090445.

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan

Nat Commun. 2021; 12: 3660. Published online 2021 Jun 16. doi: 10.1038/s41467-021-23857-8

PMCID:: PMC8209044

Abstract Article PDF–5.8M

Select item 80703996.

Alcohol Acutely Antagonizes Refeeding-Induced Alterations in the Rag GTPase-Ragulator Complex in Skeletal Muscle

Lacee J. Laufenberg, Kristen T. Crowell, Charles H. Lang

Nutrients. 2021 Apr; 13(4): 1236. Published online 2021 Apr 9. doi: 10.3390/nu13041236

PMCID:: PMC8070399

Abstract Article PDF–2.1M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 79197328.

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases

Shohei Ikeda, Jihoon Nah, Akihiro Shirakabe, Peiyong Zhai, Shin-ichi Oka, Sebastiano Sciarretta, Kun-Liang Guan, Hiroaki Shimokawa, Junichi Sadoshima

J Clin Invest. 2021 Mar 1; 131(5): e143173. Published online 2021 Mar 1. doi: 10.1172/JCI143173

PMCID:: PMC7919732

Abstract Article PDF–8.4M

Select item 70372509.

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

Mytrang H. Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, Alejo Efeyan, David M. Sabatini, Ming O. Li

J Exp Med. 2020 Jan 6; 217(1): e20190848. Published online 2019 Oct 24. doi: 10.1084/jem.20190848

PMCID:: PMC7037250

Abstract Article PDF–3.9M

Select item 633575710.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

Salim Megat, Pradipta R. Ray, Jamie K. Moy, Tzu-Fang Lou, Paulino Barragán-Iglesias, Yan Li, Grishma Pradhan, Andi Wanghzou, Ayesha Ahmad, Michael D. Burton, Robert Y. North, Patrick M. Dougherty, Arkady Khoutorsky, Nahum Sonenberg, Kevin R. Webster, Gregory Dussor, Zachary T. Campbell, Theodore J. Price

J Neurosci. 2019 Jan 16; 39(3): 393–411. doi: 10.1523/JNEUROSCI.2661-18.2018

PMCID:: PMC6335757

Abstract Article PDF–6.1M

Select item 552644811.

Germinal center selection and affinity maturation require dynamic regulation of mTORC1 kinase

Jonatan Ersching, Alejo Efeyan, Luka Mesin, Johanne T. Jacobsen, Giulia Pasqual, Brian C. Grabiner, David Dominguez-Sola, David M. Sabatini, Gabriel D. Victora

Immunity. Author manuscript; available in PMC 2018 Jun 20.

Published in final edited form as: Immunity. 2017 Jun 20; 46(6): 1045–1058.e6. doi: 10.1016/j.immuni.2017.06.005

PMCID:: PMC5526448

Abstract Article PDF–1.4M

Select item 537386312.

Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

Demetrios Kalaitzidis, Dongjun Lee, Alejo Efeyan, Youmna Kfoury, Naema Nayyar, David B. Sykes, Francois E. Mercier, Ani Papazian, Ninib Baryawno, Gabriel D. Victora, Donna Neuberg, David M. Sabatini, David T. Scadden

J Clin Invest. 2017 Apr 3; 127(4): 1405–1413. Published online 2017 Mar 20. doi: 10.1172/JCI89452

PMCID:: PMC5373863

Abstract Article PDF–1.2M

Select item 438488813.

Differential regulation of mTORC1 by leucine and glutamine

Jenna L. Jewell, Young Chul Kim, Ryan C. Russell, Fa-Xing Yu, Hyun Woo Park, Steven W. Plouffe, Vincent S. Tagliabracci, Kun-Liang Guan

Science. Author manuscript; available in PMC 2015 Apr 3.

Published in final edited form as: Science. 2015 Jan 9; 347(6218): 194–198. Published online 2015 Jan 7. doi: 10.1126/science.1259472

PMCID:: PMC4384888

Abstract Article PDF–541K

Select item 419411214.

Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

Brad Lackford, Chengguo Yao, Georgette M Charles, Lingjie Weng, Xiaofeng Zheng, Eun-A Choi, Xiaohui Xie, Ji Wan, Yi Xing, Johannes M Freudenberg, Pengyi Yang, Raja Jothi, Guang Hu, Yongsheng Shi

EMBO J. 2014 Apr 16; 33(8): 878–889. Published online 2014 Mar 4. doi: 10.1002/embj.201386537

PMCID:: PMC4194112

Abstract Article PDF–1.8M

Select item 410021415.

Rag GTPases are cardioprotective by regulating lysosomal function

Young Chul Kim, Hyun Woo Park, Sebastiano Sciarretta, Jung-Soon Mo, Jenna L. Jewell, Ryan C. Russell, Xiaohui Wu, Junichi Sadoshima, Kun-Liang Guan

Nat Commun. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Nat Commun. 2014; 5: 4241. Published online 2014 Jul 1. doi: 10.1038/ncomms5241

PMCID:: PMC4100214

Abstract Article PDF–1.7M

Select item 403555316.

RagA, but not RagB, is essential for embryonic development and adult mice

Alejo Efeyan, Lawrence D. Schweitzer, Angelina M. Bilate, Steven Chang, Oktay Kirak, Dudley W. Lamming, David M. Sabatini

Dev Cell. Author manuscript; available in PMC 2015 May 12.

Published in final edited form as: Dev Cell. 2014 May 12; 29(3): 321–329. Published online 2014 Apr 24. doi: 10.1016/j.devcel.2014.03.017

PMCID:: PMC4035553

Abstract Article PDF–2.0M

Select item 400070517.

Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

Alejo Efeyan, Roberto Zoncu, Steven Chang, Iwona Gumper, Harriet Snitkin, Rachel L. Wolfson, Oktay Kirak, David D. Sabatini, David M. Sabatini

Nature. Author manuscript; available in PMC 2014 Apr 27.

Published in final edited form as: Nature. 2013 Jan 31; 493(7434): 679–683. Published online 2012 Dec 23. doi: 10.1038/nature11745

PMCID:: PMC4000705

Abstract Article PDF–1.6M

Select item 336200418.

Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine

Ly Q. Hong-Brown, C. Randell Brown, Abid A. Kazi, Maithili Navaratnarajah, Charles H. Lang

Am J Physiol Cell Physiol. 2012 May 15; 302(10): C1557–C1565. Published online 2012 Mar 21. doi: 10.1152/ajpcell.00407.2011

PMCID:: PMC3362004

Abstract Article

Select item 321111219.

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the Vacuolar H⁺-ATPase

Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M. Sabatini

Science. Author manuscript; available in PMC 2011 Nov 9.

Published in final edited form as: Science. 2011 Nov 4; 334(6056): 678–683. doi: 10.1126/science.1207056

PMCID:: PMC3211112

Abstract Article PDF–2.2M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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