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Select item 73328091.

RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma

Zhaoming Lu, Xiaojing Shi, Fanghua Gong, Shenglei Li, Yang Wang, Yandan Ren, Mengyin Zhang, Bin Yu, Yan Li, Wen Zhao, Jianying Zhang, Guiqin Hou

Acta Pharm Sin B. 2020 Jun; 10(6): 1004–1019. Published online 2020 Jan 26. doi: 10.1016/j.apsb.2020.01.010

PMCID:: PMC7332809

Abstract Article PDF–5.2M

Select item 71151282.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

Select item 62243353.

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis

Katharina M. Schmidt, Peter Dietrich, Christina Hackl, Jessica Guenzle, Peter Bronsert, Christine Wagner, Stefan Fichtner-Feigl, Hans J. Schlitt, Edward K. Geissler, Claus Hellerbrand, Sven A. Lang

Neoplasia. 2018 Dec; 20(12): 1198–1208. Published online 2018 Nov 4. doi: 10.1016/j.neo.2018.10.001

PMCID:: PMC6224335

Abstract Article PDF–1.7M

Select item 59929854.

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

Zhong Xu, Junjie Hu, Hui Cao, Maria G Pilo, Antonio Cigliano, Zixuan Shao, Meng Xu, Silvia Ribback, Frank Dombrowski, Diego F Calvisi, Xin Chen

Exp Mol Med. 2018 Jan; 50(1): e417. Published online 2018 Jan 5. doi: 10.1038/emm.2017.158

PMCID:: PMC5992985

Abstract Article PDF–2.9M

Select item 59764385.

mTORC1 and mTORC2 differentially promote natural killer cell development

Chao Yang, Shirng-Wern Tsaih, Angela Lemke, Michael J Flister, Monica S Thakar, Subramaniam Malarkannan

eLife. 2018; 7: e35619. Published online 2018 May 29. doi: 10.7554/eLife.35619

PMCID:: PMC5976438

Abstract Article PDF–5.0M

Select item 55773936.

mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons

Han-Kyu Lee, Bumsup Kwon, Cynthia A. Lemere, Suzanne de la Monte, Kyohei Itamura, Austin Y. Ha, Henry W. Querfurth

J Alzheimers Dis. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2017; 56(3): 1015–1036. doi: 10.3233/JAD-161029

PMCID:: PMC5577393

Abstract Article PDF–2.9M

Select item 53516077.

RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR

Nneha Sakre, Gary Wildey, Mohadese Behtaj, Adam Kresak, Michael Yang, Pingfu Fu, Afshin Dowlati

Oncotarget. 2017 Jan 24; 8(4): 5992–6002. Published online 2016 Nov 15. doi: 10.18632/oncotarget.13362

PMCID:: PMC5351607

Abstract Article PDF–4.6M

Select item 46708068.

RICTOR amplification defines a novel subset of lung cancer patients who may benefit from treatment with mTOR1/2 inhibitors

Haiying Cheng, Yiyu Zou, Jeffrey S. Ross, Kai Wang, Xuewen Liu, Balazs Halmos, Siraj M Ali, Huijie Liu, Amit Verma, Cristina Montagna, Abraham Chachoua, Sanjay Goel, Edward L. Schwartz, Changcheng Zhu, Jidong Shan, Yiting Yu, Kira Gritsman, Roman Yelensky, Doron Lipson, Geoff Otto, Matthew Hawryluk, Philip J. Stephens, Vincent A. Miller, Bilal Piperdi, Roman Perez-Soler

Cancer Discov. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Cancer Discov. 2015 Dec; 5(12): 1262–1270. Published online 2015 Sep 14. doi: 10.1158/2159-8290.CD-14-0971

PMCID:: PMC4670806

Abstract Article PDF–383K

Select item 45585699.

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis

Jianzhong Li, Jiafa Ren, Xin Liu, Lei Jiang, Weichun He, Weiping Yuan, Junwei Yang, Chunsun Dai

Kidney Int. 2015 Sep; 88(3): 515–527. Published online 2015 May 13. doi: 10.1038/ki.2015.119

PMCID:: PMC4558569

Abstract Article PDF–4.0M

Select item 446666010.

The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer

Guopei Zheng, Xiaoting Jia, Cong Peng, Yingen Deng, Jiang Yin, Zhijie Zhang, Nan Li, Min Deng, Xiaorong Liu, Hao Liu, Minying Lu, Chengkun Wang, Yixue Gu, Zhimin He

Oncotarget. 2015 Mar 30; 6(9): 6931–6943. Published online 2015 Feb 19. doi: 10.18632/oncotarget.3165

PMCID:: PMC4466660

Abstract Article PDF–11M

Select item 444798211.

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

Junghui Koo, Xiaoyun Wu, Zixu Mao, Fadlo R. Khuri, Shi-Yong Sun

J Biol Chem. 2015 May 29; 290(22): 14120–14129. Published online 2015 Apr 20. doi: 10.1074/jbc.M114.633057

PMCID:: PMC4447982

Abstract Article PDF–2.5M

Select item 442857112.

Molecular Characterization of Gallbladder Cancer using Somatic Mutation Profiling

Milind Javle, Asif Rashid, Chaitanya Churi, Siddhartha Kar, Mingxin Zuo, Agda Karina Eterovic, Graciela M. Nogueras-Gonzalez, Siraj Ali, Filip Janku, Rachna Shroff, Thomas A Aloia, Jean-Nicholas Vauthey, Steven Curley, Gordon Mills, Ivan Roa

Hum Pathol. Author manuscript; available in PMC 2015 May 12.

Published in final edited form as: Hum Pathol. 2014 Apr; 45(4): 701–708. Published online 2013 Nov 12. doi: 10.1016/j.humpath.2013.11.001

PMCID:: PMC4428571

Abstract Article PDF–2.0M

Select item 398932113.

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

William T. Festuccia, Philippe Pouliot, Inan Bakan, David M. Sabatini, Mathieu Laplante

PLoS One. 2014; 9(4): e95432. Published online 2014 Apr 16. doi: 10.1371/journal.pone.0095432

PMCID:: PMC3989321

Abstract Article PDF–3.1M

Select item 396869014.

mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension

Dmitry A. Goncharov, Tatiana V. Kudryashova, Houman Ziai, Kaori Ihida-Stansbury, Horace DeLisser, Vera P. Krymskaya, Rubin M. Tuder, Steven M. Kawut, Elena A. Goncharova

Circulation. Author manuscript; available in PMC 2015 Feb 25.

Published in final edited form as: Circulation. 2014 Feb 25; 129(8): 864–874. Published online 2013 Nov 22. doi: 10.1161/CIRCULATIONAHA.113.004581

PMCID:: PMC3968690

Abstract Article PDF–1.2M

Select item 382366115.

MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression

Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii, Masato Okada

PLoS One. 2013; 8(11): e80300. Published online 2013 Nov 11. doi: 10.1371/journal.pone.0080300