PMC Links for GEO Profiles (Select 38339721) - PMC

Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat, Ebenezer N. Yamoah

Nat Commun. 2024; 15: 526. Published online 2024 Jan 16. doi: 10.1038/s41467-023-44230-x

PMCID:: PMC10791687

Abstract Article PDF–5.3M

Select item 104276234.

Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo

Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen

Nat Commun. 2023; 14: 4928. Published online 2023 Aug 15. doi: 10.1038/s41467-023-40476-7

PMCID:: PMC10427623

Abstract Article PDF–7.2M

Select item 103242785.

USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang, Fan Zhang

Biol Direct. 2023; 18: 37. Published online 2023 Jul 6. doi: 10.1186/s13062-023-00395-5

PMCID:: PMC10324278

Abstract Article PDF–2.7M

Select item 102893746.

The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells

Soichiro Yamaguchi, Maho Kamino, Maho Hamamura, Ken-ichi Otsuguro

PLoS One. 2023; 18(6): e0287249. Published online 2023 Jun 23. doi: 10.1371/journal.pone.0287249

PMCID:: PMC10289374

Abstract Article PDF–3.3M

Select item 101473777.

Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system

Michelle M Frank, Austen A Sitko, Kirupa Suthakar, Lester Torres Cadenas, Mackenzie Hunt, Mary Caroline Yuk, Catherine JC Weisz, Lisa V Goodrich

eLife. 2023; 12: e83855. Published online 2023 Mar 6. doi: 10.7554/eLife.83855

PMCID:: PMC10147377

Abstract Article PDF–24M

Select item 95648238.

The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells

Robert Fettiplace, David N. Furness, Maryline Beurg

Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2210849119. Published online 2022 Oct 3. doi: 10.1073/pnas.2210849119

PMCID:: PMC9564823

Abstract Article PDF–2.0M

Select item 93487959.

Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing

Angela Ballesteros, Kenton J. Swartz

Sci Adv. 2022 Aug; 8(31): eabm5550. Published online 2022 Aug 3. doi: 10.1126/sciadv.abm5550

PMCID:: PMC9348795

Abstract Article PDF–20M

Select item 931313310.

Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11

Irina Marcovich, Nicholas K. Baer, Olga Shubina-Oleinik, Rachel Eclov, Clayton W. Beard, Jeffrey R. Holt

Biomolecules. 2022 Jul; 12(7): 914. Published online 2022 Jun 29. doi: 10.3390/biom12070914

PMCID:: PMC9313133

Abstract Article PDF–5.3M

Select item 927887011.

Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

Nurunisa Akyuz, K. Domenica Karavitaki, Bifeng Pan, Panos I. Tamvakologos, Kelly P. Brock, Yaqiao Li, Debora S. Marks, David P. Corey

Sci Adv. 2022 Jul; 8(28): eabo1126. Published online 2022 Jul 13. doi: 10.1126/sciadv.abo1126

PMCID:: PMC9278870

Abstract Article PDF–2.6M

Select item 925035712.

Ca²⁺ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips

Julia Halford, Michael Bateschell, Peter G. Barr-Gillespie

Mol Biol Cell. 2022 Apr 1; 33(4): br6. Published online 2022 Mar 29. doi: 10.1091/mbc.E21-10-0491

PMCID:: PMC9250357

Abstract Article PDF–14M

Select item 859815813.

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

John Lee, Kosuke Kawai, Jeffrey R Holt, Gwenaëlle SG Géléoc

eLife. 2021; 10: e69433. Published online 2021 Nov 4. doi: 10.7554/eLife.69433

PMCID:: PMC8598158

Abstract Article PDF–5.0M

Select item 838380814.

The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis

Maryline Beurg, Jong-Hoon Nam, Robert Fettiplace

J Gen Physiol. 2021 Oct 4; 153(10): e202112959. Published online 2021 Aug 19. doi: 10.1085/jgp.202112959

PMCID:: PMC8383808

Abstract Article PDF–3.2M

Select item 837495915.

CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells

Xiaoping Liang, Xufeng Qiu, Gilman Dionne, Christopher L. Cunningham, Michele L. Pucak, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Lawrence Shapiro, Ulrich Müller

Neuron. Author manuscript; available in PMC 2022 Jul 7.

Published in final edited form as: Neuron. 2021 Jul 7; 109(13): 2131–2149.e15. Published online 2021 Jun 5. doi: 10.1016/j.neuron.2021.05.007

PMCID:: PMC8374959

Abstract Article PDF–3.9M

Select item 828597816.

PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice

Jie Li, Shuang Liu, Chenmeng Song, Qun Hu, Zhikai Zhao, Tuantuan Deng, Yi Wang, Tong Zhu, Linzhi Zou, Shufeng Wang, Jiaofeng Chen, Lian Liu, Hanqing Hou, Kexin Yuan, Hairong Zheng, Zhiyong Liu, Xiaowei Chen, Wenzhi Sun, Bailong Xiao, Wei Xiong

Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28): e2101207118. Published online 2021 Jul 8. doi: 10.1073/pnas.2101207118