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Select item 114054491.

Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis

Mónica Zufiría, Oihane Pikatza-Menoio, Maddi Garciandia-Arcelus, Xabier Bengoetxea, Andrés Jiménez, Amaia Elicegui, María Levchuk, Olatz Arnold-García, Jon Ondaro, Pablo Iruzubieta, Laura Rodríguez-Gómez, Uxoa Fernández-Pelayo, Mikel Muñoz-Oreja, Ana Aiastui, José Manuel García-Verdugo, Vicente Herranz-Pérez, Miren Zulaica, Juan José Poza, Rebeca Ruiz-Onandi, Roberto Fernández-Torrón, Juan Bautista Espinal, Mario Bonilla, Ana Lersundi, Gorka Fernández-Eulate, Javier Riancho, Ainara Vallejo-Illarramendi, Ian James Holt, Amets Sáenz, Edoardo Malfatti, Stéphanie Duguez, Lorea Blázquez, Adolfo López de Munain, Gorka Gerenu, Francisco Gil-Bea, Sonia Alonso-Martín

Acta Neuropathol. 2024; 148(1): 43. Published online 2024 Sep 16. doi: 10.1007/s00401-024-02794-y

PMCID:: PMC11405449

Abstract Article PDF–15M

Select item 110723322.

Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers

Francesco Liguori, Susanna Amadio, Cinzia Volonté

Cell Mol Life Sci. 2021 Sep; 78(17-18): 6143–6160. Published online 2021 Jul 28. doi: 10.1007/s00018-021-03905-8

PMCID:: PMC11072332

Abstract Article PDF–1.2M

Select item 109457073.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109449314.

Invertebrate genetic models of amyotrophic lateral sclerosis

LiJun Zhou, RenShi Xu

Front Mol Neurosci. 2024; 17: 1328578. Published online 2024 Mar 4. doi: 10.3389/fnmol.2024.1328578

PMCID:: PMC10944931

Abstract Article PDF–2.0M

Select item 108987405.

Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing

Daniel C. Sutton, Jonathan C. Andrews, Dylan M. Dolezal, Ye Jin Park, Hongjie Li, Daniel F. Eberl, Shinya Yamamoto, Andrew K. Groves

PLoS One. 2024; 19(2): e0297846. Published online 2024 Feb 27. doi: 10.1371/journal.pone.0297846

PMCID:: PMC10898740

Abstract Article PDF–2.8M

Select item 107885316.

A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor

Ana-Maria Raicu, Megha Suresh, David N. Arnosti

J Biol Chem. 2024 Jan; 300(1): 105490. Published online 2023 Nov 23. doi: 10.1016/j.jbc.2023.105490

PMCID:: PMC10788531

Abstract Article PDF–1.4M

Select item 106917527.

Ribosomal protein mutations and cell competition: autonomous and nonautonomous effects on a stress response

Marianthi Kiparaki, Nicholas E Baker

Genetics. 2023 Jul; 224(3): iyad080. Published online 2023 Jun 2. doi: 10.1093/genetics/iyad080

PMCID:: PMC10691752

Abstract Article PDF–594K

Select item 105338678.

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration

Marta Marzullo, Giulia Romano, Claudia Pellacani, Federico Riccardi, Laura Ciapponi, Fabian Feiguin

Cell Death Discov. 2023; 9: 357. Published online 2023 Sep 27. doi: 10.1038/s41420-023-01643-3

PMCID:: PMC10533867

Abstract Article PDF–2.2M

Select item 105237619.

Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration

Marina L. Garcia-Vaquero, Marjorie Heim, Barbara Flix, Marcelo Pereira, Lucile Palin, Tânia M. Marques, Francisco R. Pinto, Javier de Las Rivas, Aaron Voigt, Florence Besse, Margarida Gama-Carvalho

BMC Genomics. 2023; 24: 576. Published online 2023 Sep 27. doi: 10.1186/s12864-023-09562-4

PMCID:: PMC10523761

Abstract Article PDF–3.2M

Select item 1039304610.

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, Toshihide Takeuchi, Yoshiaki Furukawa, Toshimichi Fujiwara, Manabu Ikeda, Toshiki Mizuno, Hideki Mochizuki, Hidehiro Mizusawa, Keiji Wada, Kinya Ishikawa, Osamu Onodera, Kazuhiko Nakatani, Leonard Petrucelli, Hideki Taguchi, Yoshitaka Nagai

eLife. 2023; 12: RP84338. Published online 2023 Jul 18. doi: 10.7554/eLife.84338

PMCID:: PMC10393046

Abstract Article PDF–23M

Select item 1023277511.

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellosta

Front Neurosci. 2023; 17: 1082047. Published online 2023 May 18. doi: 10.3389/fnins.2023.1082047

PMCID:: PMC10232775

Abstract Article PDF–2.4M

Select item 1021319912.

RNAseq analysis of the drug jian-yan-ling (JYL) using both in vivo and in vitro models

Xiaobo Zhang, Yunliang Zhai, Dandan Zhang, Chang Che, Yayun Zhang, Quan Li, Xue Zhang, Lingrui Zhao

Heliyon. 2023 May; 9(5): e16143. Published online 2023 May 19. doi: 10.1016/j.heliyon.2023.e16143

PMCID:: PMC10213199

Abstract Article PDF–5.2M

Select item 993859013.

Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5

Matanel Yheskel, Simone Sidoli, Julie Secombe

Epigenetics Chromatin. 2023; 16: 8. Published online 2023 Feb 18. doi: 10.1186/s13072-023-00481-y

PMCID:: PMC9938590

Abstract Article PDF–4.8M

Select item 943373114.

Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease

Shweta Tendulkar, Sushmitha Hegde, Lovleen Garg, Aparna Thulasidharan, Bhagyashree Kaduskar, Anuradha Ratnaparkhi, Girish S Ratnaparkhi

Hum Mol Genet. 2022 Sep 1; 31(17): 2857–2875. Published online 2022 Apr 4. doi: 10.1093/hmg/ddac076

PMCID:: PMC9433731

Abstract Article PDF–2.1M

Select item 929573415.

Identification of PSMB5 as a genetic modifier of fragile X–associated tremor/ataxia syndrome

Ha Eun Kong, Junghwa Lim, Alexander Linsalata, Yunhee Kang, Indranil Malik, Emily G. Allen, Yiqu Cao, Lisa Shubeck, Rich Johnston, Yanting Huang, Yanghong Gu, Xiangxue Guo, Michael E. Zwick, Zhaohui Qin, Thomas S. Wingo, Jorge Juncos, David L. Nelson, Michael P. Epstein, David J. Cutler, Peter K. Todd, Stephanie L. Sherman, Stephen T. Warren, Peng Jin

Proc Natl Acad Sci U S A. 2022 May 31; 119(22): e2118124119. Published online 2022 May 26. doi: 10.1073/pnas.2118124119

PMCID:: PMC9295734

Abstract Article PDF–2.3M

Select item 866448616.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 865212517.

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models

Sharifah Anoar, Nathaniel S. Woodling, Teresa Niccoli

Front Neurosci. 2021; 15: 786076. Published online 2021 Nov 24. doi: 10.3389/fnins.2021.786076

PMCID:: PMC8652125

Abstract Article PDF–1.9M

Select item 863664118.

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Friederike L. Pennemann, Assel Mussabekova, Christian Urban, Alexey Stukalov, Line Lykke Andersen, Vincent Grass, Teresa Maria Lavacca, Cathleen Holze, Lila Oubraham, Yasmine Benamrouche, Enrico Girardi, Rasha E. Boulos, Rune Hartmann, Giulio Superti-Furga, Matthias Habjan, Jean-Luc Imler, Carine Meignin, Andreas Pichlmair

Nat Commun. 2021; 12: 7009. Published online 2021 Dec 1. doi: 10.1038/s41467-021-27192-w

PMCID:: PMC8636641

Abstract Article PDF–2.9M

Select item 848678519.

Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling

Pedro Machado Almeida, Blanca Lago Solis, Luca Stickley, Alexis Feidler, Emi Nagoshi

Nat Commun. 2021; 12: 5758. Published online 2021 Oct 1. doi: 10.1038/s41467-021-26031-2

PMCID:: PMC8486785

Abstract Article PDF–3.2M

Select item 811517920.

Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium

Elsayed Metwally, Guoli Zhao, Qifu Wang, Yong Q. Zhang

Cell Res. 2021 Apr; 31(4): 433–449. Published online 2020 Aug 26. doi: 10.1038/s41422-020-0388-4

PMCID:: PMC8115179

Abstract Article PDF–7.5M

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