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Select item 111132681.

Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster

Analisa L. Taylor, Olga Dubuisson, Pritika Pandey, Elizabeth R. M. Zunica, Bolormaa Vandanmagsar, Wagner S. Dantas, Alyssa Johnson, Christopher L. Axelrod, John P. Kirwan

Aging Cell. 2024 May; 23(5): e14107. Published online 2024 Feb 11. doi: 10.1111/acel.14107

PMCID:: PMC11113268

Abstract Article PDF–655K

Select item 109359542.

Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila

Laura Vesala, Yuliya Basikhina, Tea Tuomela, Anssi Nurminen, Emilia Siukola, Pedro F. Vale, Tiina S. Salminen

BMC Biol. 2024; 22: 60. Published online 2024 Mar 13. doi: 10.1186/s12915-024-01858-5

PMCID:: PMC10935954

Abstract Article PDF–2.4M

Select item 104741263.

Nacα protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila

Takayuki Yamada, Yuto Yoshinari, Masayuki Tobo, Okiko Habara, Takashi Nishimura

Nat Commun. 2023; 14: 5328. Published online 2023 Sep 1. doi: 10.1038/s41467-023-41103-1

PMCID:: PMC10474126

Abstract Article PDF–13M

Select item 103916754.

The tardigrade Dsup protein enhances radioresistance in Drosophila melanogaster and acts as an unspecific repressor of transcription

Mikhail Zarubin, Talyana Azorskaya, Olga Kuldoshina, Sergey Alekseev, Semen Mitrofanov, Elena Kravchenko

iScience. 2023 Jul 21; 26(7): 106998. Published online 2023 May 29. doi: 10.1016/j.isci.2023.106998

PMCID:: PMC10391675

Abstract Article PDF–3.0M

Select item 103013865.

Zearalenone Does Not Show Genotoxic Effects in the Drosophila melanogaster Wing Spot Test, but It Induces Oxidative Imbalance, Development, and Fecundity Alterations

Luis Felipe Santos-Cruz, Alberto Ponciano-Gómez, Juan Tomás Torres-Gregorio, Bertha Guadalupe Ramírez-Cruz, Gerardo Vázquez-Gómez, Luis Barbo Hernández-Portilla, Cesar Mateo Flores-Ortiz, Irma Elena Dueñas-García, María Eugenia Heres-Pulido, Laura Castañeda-Partida, Ángel Durán-Díaz, Myriam Campos-Aguilar, Santiago Cristobal Sigrist-Flores, Elías Piedra-Ibarra

Toxins (Basel) 2023 Jun; 15(6): 358. Published online 2023 May 25. doi: 10.3390/toxins15060358

PMCID:: PMC10301386

Abstract Article PDF–2.8M

Select item 102207406.

Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue

Biko K. Muita, Simon W. Baxter

Toxins (Basel) 2023 May; 15(5): 323. Published online 2023 May 7. doi: 10.3390/toxins15050323

PMCID:: PMC10220740

Abstract Article PDF–3.2M

Select item 97509647.

An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S. Chahal, Jiamin Zhao, Peter M. Colman, Leonie M. Quinn, Jacqueline M. Gulbis

Sci Rep. 2022; 12: 21634. Published online 2022 Dec 14. doi: 10.1038/s41598-022-23280-z

PMCID:: PMC9750964

Abstract Article PDF–12M

Select item 95239978.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 94745459.

Mettl3-dependent m⁶A modification attenuates the brain stress response in Drosophila

Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu, Nancy M. Bonini

Nat Commun. 2022; 13: 5387. Published online 2022 Sep 14. doi: 10.1038/s41467-022-33085-3

PMCID:: PMC9474545

Abstract Article PDF–2.7M

Select item 945842110.

The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes

Ruirui Jia, Jiamei Lin, Jin You, Shi Li, Ge Shan, Chuan Huang

Nucleic Acids Res. 2022 Sep 9; 50(16): 9175–9189. Published online 2022 Aug 11. doi: 10.1093/nar/gkac684

PMCID:: PMC9458421

Abstract Article PDF–2.5M

Select item 927386811.

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform

Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov

Front Aging Neurosci. 2022; 14: 914017. Published online 2022 Jun 28. doi: 10.3389/fnagi.2022.914017

PMCID:: PMC9273868

Abstract Article PDF–3.6M

Select item 909466712.

IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system

Anjaneyulu Murari, Naga S. V. Goparaju, Shauna-Kay Rhooms, Kaniz F. B. Hossain, Felix G. Liang, Christian J. Garcia, Cindy Osei, Tong Liu, Hong Li, Richard N. Kitsis, Rajesh Patel, Edward Owusu-Ansah

Sci Adv. 2022 May; 8(19): eabl8716. Published online 2022 May 11. doi: 10.1126/sciadv.abl8716

PMCID:: PMC9094667

Abstract Article PDF–21M

Select item 883299713.

The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1

Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, Zhouhua Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111711119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111711119

PMCID:: PMC8832997

Abstract Article PDF–4.4M

Select item 866448614.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 849627715.

A cross-species approach for the identification of Drosophila male sterility genes

Kimihide Ibaraki, Mihoko Nakatsuka, Takashi Ohsako, Masahide Watanabe, Yu Miyazaki, Machi Shirakami, Timothy L Karr, Rikako Sanuki, Masatoshi Tomaru, Toshiyuki Takano-Shimizu-Kouno

G3 (Bethesda) 2021 Aug; 11(8): jkab183. Published online 2021 May 29. doi: 10.1093/g3journal/jkab183