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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105094612.

Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development

Sarah Gruenbacher, Markus Jaritz, Louisa Hill, Markus Schäfer, Meinrad Busslinger

J Exp Med. 2023 Dec 4; 220(12): e20230260. Published online 2023 Sep 19. doi: 10.1084/jem.20230260

PMCID:: PMC10509461

Abstract Article PDF–7.6M

Select item 104498873.

Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice

Marta Isidro-Hernández, Ana Casado-García, Ninad Oak, Silvia Alemán-Arteaga, Belén Ruiz-Corzo, Jorge Martínez-Cano, Andrea Mayado, Elena G. Sánchez, Oscar Blanco, Ma Luisa Gaspar, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Manuel Ramírez-Orellana, Belén de Andrés, Carolina Vicente-Dueñas, César Cobaleda, Kim E. Nichols, Isidro Sánchez-García

Nat Commun. 2023; 14: 5159. Published online 2023 Aug 24. doi: 10.1038/s41467-023-40961-z

PMCID:: PMC10449887

Abstract Article PDF–8.2M

Select item 103908774.

Enhancers of the PAIR4 regulatory module promote distal V_H gene recombination at the Igh locus

Louisa Hill, Markus Jaritz, Hiromi Tagoh, Karina Schindler, Daniela Kostanova‐Poliakova, Qiong Sun, Tanja A Schwickert, Martin Leeb, Meinrad Busslinger

EMBO J. 2023 Aug; 42(15): e112741. Published online 2023 Jun 20. doi: 10.15252/embj.2022112741

PMCID:: PMC10390877

Abstract Article PDF–1.5M

Select item 102536675.

The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer

Luis Puelles, Matias Hidalgo-Sánchez

Int J Mol Sci. 2023 Jun; 24(11): 9769. Published online 2023 Jun 5. doi: 10.3390/ijms24119769

PMCID:: PMC10253667

Abstract Article PDF–6.8M

Select item 99343636.

Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development

Daniel Aldea, Blerina Kokalari, Yuji Atsuta, Heather L. Dingwall, Ying Zheng, Arben Nace, George Cotsarelis, Yana G. Kamberov

PLoS Genet. 2023 Feb; 19(2): e1010614. Published online 2023 Feb 6. doi: 10.1371/journal.pgen.1010614

PMCID:: PMC9934363

Abstract Article PDF–1.9M

Select item 99279417.

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling

J Clin Invest. 2023 Feb 15; 133(4): e163612. Published online 2023 Feb 15. doi: 10.1172/JCI163612

PMCID:: PMC9927941

Abstract Article PDF–3.0M

Select item 94450708.

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa

Yubo Zhao, Jian Song, Weiwei Dong, Xiaobai Liu, Chunqing Yang, Di Wang, Yixue Xue, Xuelei Ruan, Libo Liu, Ping Wang, Mengyang Zhang, Yunhui Liu

Cell Death Dis. 2022 Sep; 13(9): 767. Published online 2022 Sep 5. doi: 10.1038/s41419-022-05219-4

PMCID:: PMC9445070

Abstract Article PDF–5.4M

Select item 93597299.

Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice

Ana Casado-García, Marta Isidro-Hernández, Ninad Oak, Andrea Mayado, Christine Mann-Ran, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alexandra Buhles, Dario Sterker, Elena G. Sánchez, Jorge Martínez-Cano, Oscar Blanco, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, Susana Riesco, Pablo Prieto-Matos, África González-Murillo, Francisco Javier García Criado, María Begoña García Cenador, Thomas Radimerski, Manuel Ramírez-Orellana, César Cobaleda, Jun J. Yang, Carolina Vicente-Dueñas, Andreas Weiss, Kim E. Nichols, Isidro Sánchez-García

Cancer Res. 2022 Mar 15; 82(6): 1098–1109. Published online 2022 Mar 15. doi: 10.1158/0008-5472.CAN-21-3386

PMCID:: PMC9359729

Abstract Article PDF–1.2M

Select item 928293010.

Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson’s disease model

Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Chen

J Clin Invest. 2022 Jul 15; 132(14): e156768. Published online 2022 Jul 15. doi: 10.1172/JCI156768

PMCID:: PMC9282930

Abstract Article PDF–19M

Select item 914987011.

Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero

Hong-Ming Zhou, Simon J. Conway

J Dev Biol. 2022 Jun; 10(2): 19. Published online 2022 May 17. doi: 10.3390/jdb10020019

PMCID:: PMC9149870

Abstract Article PDF–3.7M

Select item 898262512.

The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation

Sabine Jurado, Anna S Fedl, Markus Jaritz, Daniela Kostanova‐Poliakova, Stephen G Malin, Charles G Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger

EMBO J. 2022 Apr; 41(7): e108397. Published online 2022 Feb 14. doi: 10.15252/embj.2021108397

PMCID:: PMC8982625

Abstract Article PDF–2.4M

Select item 861691513.

Pax5 mediates the transcriptional activation of the CD81 gene

Kohei Hosokawa, Hanako Ishimaru, Tadashi Watanabe, Masahiro Fujimuro

Sci Rep. 2021; 11: 22919. Published online 2021 Nov 25. doi: 10.1038/s41598-021-02082-9

PMCID:: PMC8616915

Abstract Article PDF–2.7M

Select item 817676414.

EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene

Rajesh Somasundaram, Christina T. Jensen, Johanna Tingvall-Gustafsson, Josefine Åhsberg, Kazuki Okuyama, Mahadesh Prasad, James R. Hagman, Xun Wang, Shamit Soneji, Tobias Strid, Jonas Ungerbäck, Mikael Sigvardsson

Blood. 2021 Jun 3; 137(22): 3037–3049. Prepublished online 2021 Feb 22. doi: 10.1182/blood.2020009564

PMCID:: PMC8176764

Abstract Article

Select item 792375415.

Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1

Jiyeon Yu, Sumi Kim, Nari Lee, Hyoeun Jeon, Jun Lee, Masamichi Takami, Jaerang Rho

Int J Mol Sci. 2021 Feb; 22(4): 2097. Published online 2021 Feb 20. doi: 10.3390/ijms22042097

PMCID:: PMC7923754

Abstract Article PDF–2.5M

Select item 781571216.

Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy

A. Hörnblad, S. Bastide, K. Langenfeld, F. Langa, F. Spitz

Nat Commun. 2021; 12: 439. Published online 2021 Jan 19. doi: 10.1038/s41467-020-20714-y

PMCID:: PMC7815712

Abstract Article PDF–3.4M

Select item 764472217.

Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

Marta Isidro-Hernández, Andrea Mayado, Ana Casado-García, Jorge Martínez-Cano, Chiara Palmi, Grazia Fazio, Alberto Orfao, Jordi Ribera, Josep Maria Ribera, Lurdes Zamora, Javier Raboso-Gallego, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Rafael Jiménez, Francisco Javier García Criado, María Begoña García Cenador, Manuel Ramírez-Orellana, Giovanni Cazzaniga, César Cobaleda, Carolina Vicente-Dueñas, Isidro Sánchez-García

Sci Rep. 2020; 10: 19189. Published online 2020 Nov 5. doi: 10.1038/s41598-020-76206-y

PMCID:: PMC7644722

Abstract Article PDF–4.1M

Select item 761144918.

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN downregulation

Lesly Calderón, Karina Schindler, Stephen G. Malin, Alexandra Schebesta, Qiong Sun, Tanja Schwickert, Chiara Alberti, Maria Fischer, Markus Jaritz, Hiromi Tagoh, Anja Ebert, Martina Minnich, Adrian Liston, Luisa Cochella, Meinrad Busslinger

Sci Immunol. Author manuscript; available in PMC 2022 Jan 23.

Published in final edited form as: Sci Immunol. 2021 Jul 23; 6(61): eabg5003. Published online 2021 Jul 23. doi: 10.1126/sciimmunol.abg5003

PMCID:: PMC7611449

Abstract Article PDF–4.1M

Select item 748390819.

DDX3X suppresses the susceptibility of hindbrain lineages to medulloblastoma

Deanna M. Patmore, Amir Jassim, Erica Nathan, Reuben J. Gilbertson, Daniel Tahan, Nadin Hoffmann, Yiai Tong, Kyle S. Smith, Thirumala-Devi Kanneganti, Hiromichi Suzuki, Michael D. Taylor, Paul Northcott, Richard J. Gilbertson

Dev Cell. Author manuscript; available in PMC 2021 Aug 24.

Published in final edited form as: Dev Cell. 2020 Aug 24; 54(4): 455–470.e5. Published online 2020 Jun 17. doi: 10.1016/j.devcel.2020.05.027

PMCID:: PMC7483908

Abstract Article PDF–1.7M

Select item 737671220.

Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis

Xiaonan Dong, Kin Ming Kwan

Mol Brain. 2020; 13: 104. Published online 2020 Jul 23. doi: 10.1186/s13041-020-00643-z

PMCID:: PMC7376712

Abstract Article PDF–11M

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