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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106795122.

mRBPome capture identifies the RNA-binding protein TRIM71, an essential regulator of spermatogonial differentiation

Guihua Du, Xinrui Wang, Mengcheng Luo, Weiya Xu, Tao Zhou, Mei Wang, Luping Yu, Lufan Li, Li'e Cai, P. Jeremy Wang, John Zhong Li, Jon M. Oatley, Xin Wu

Development. 2020 Apr 15; 147(8): dev184655. Published online 2020 Apr 12. doi: 10.1242/dev.184655

PMCID:: PMC10679512

Abstract Article

Select item 104816733.

TRIM71 reactivation enhances the mitotic and hair cell–forming potential of cochlear supporting cells

Xiao‐Jun Li, Charles Morgan, Prathamesh T Nadar‐Ponniah, Waldemar Kolanus, Angelika Doetzlhofer

EMBO Rep. 2023 Sep; 24(9): e56562. Published online 2023 Jul 26. doi: 10.15252/embr.202256562

PMCID:: PMC10481673

Abstract Article PDF–5.6M

Select item 99106934.

Different congenital hydrocephalus–associated mutations in Trim71 impair stem cell differentiation via distinct gain-of-function mechanisms

Qiuying Liu, Mariah K. Novak, Rachel M. Pepin, Katharine R. Maschhoff, Wenqian Hu

PLoS Biol. 2023 Feb; 21(2): e3001947. Published online 2023 Feb 9. doi: 10.1371/journal.pbio.3001947

PMCID:: PMC9910693

Abstract Article PDF–4.6M

Select item 99003305.

A congenital hydrocephalus‐causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation

Qiuying Liu, Mariah K Novak, Rachel M Pepin, Katharine R Maschhoff, Kailey Worner, Xiaoli Chen, Shaojie Zhang, Wenqian Hu

EMBO Rep. 2023 Feb; 24(2): e55843. Published online 2022 Dec 27. doi: 10.15252/embr.202255843

PMCID:: PMC9900330

Abstract Article PDF–2.1M

Select item 96649076.

Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, Jr., June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle

Nat Neurosci. Author manuscript; available in PMC 2022 Nov 15.

Published in final edited form as: Nat Neurosci. 2022 Apr; 25(4): 458–473. Published online 2022 Apr 4. doi: 10.1038/s41593-022-01043-3

PMCID:: PMC9664907

Abstract Article PDF–6.3M

Select item 81555447.

TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility

Lucia A. Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Manon S. Oud, Sara Di Persio, Nina Neuhaus, Sabine Kliesch, Michael Hölzel, Hubert Schorle, Corinna Friedrich, Frank Tüttelmann, Waldemar Kolanus

Front Cell Dev Biol. 2021; 9: 658966. Published online 2021 May 13. doi: 10.3389/fcell.2021.658966

PMCID:: PMC8155544

Abstract Article PDF–17M

Select item 79066028.

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

Qiuying Liu, Xiaoli Chen, Mariah K Novak, Shaojie Zhang, Wenqian Hu

eLife. 2021; 10: e66288. Published online 2021 Feb 18. doi: 10.7554/eLife.66288

PMCID:: PMC7906602

Abstract Article PDF–3.2M

Select item 78390759.

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

Charuta Gavankar Furey, Jungmin Choi, Sheng Chih Jin, Xue Zeng, Andrew T. Timberlake, Carol Nelson-Williams, M. Shahid Mansuri, Qiongshi Lu, Daniel Duran, Shreyas Panchagnula, August Allocco, Jason K. Karimy, Arjun Khanna, Jonathan R. Gaillard, Tyrone DeSpenza, Prince Antwi, Erin Loring, William E. Butler, Edward R. Smith, Benjamin C. Warf, Jennifer M. Strahle, David D. Limbrick, Phillip B. Storm, Gregory Heuer, Eric M. Jackson, Bermans J. Iskandar, James M. Johnston, Irina Tikhonova, Christopher Castaldi, Francesc López-Giráldez, Robert D. Bjornson, James R. Knight, Kaya Bilguvar, Shrikant Mane, Seth L. Alper, Shozeb Haider, Bulent Guclu, Yasar Bayri, Yener Sahin, Michael L.J. Apuzzo, Charles C. Duncan, Michael L. DiLuna, Murat Günel, Richard P. Lifton, Kristopher T. Kahle

Neuron. Author manuscript; available in PMC 2021 Jan 27.

Published in final edited form as: Neuron. 2018 Jul 25; 99(2): 302–314.e4. Published online 2018 Jul 5. doi: 10.1016/j.neuron.2018.06.019

PMCID:: PMC7839075

Abstract Article PDF–1.6M

Select item 643395210.

A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

Ya-Pu Li, Fei-Fei Duan, Yu-Ting Zhao, Kai-Li Gu, Le-Qi Liao, Huai-Bin Su, Jing Hao, Kun Zhang, Na Yang, Yangming Wang

Nat Commun. 2019; 10: 1368. Published online 2019 Mar 25. doi: 10.1038/s41467-019-08911-w

PMCID:: PMC6433952

Abstract Article PDF–2.0M

Select item 544247311.

The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation

Duong Thi Thuy Nguyen, Daniel Richter, Geert Michel, Sibylle Mitschka, Waldemar Kolanus, Elisa Cuevas, F Gregory Wulczyn

Cell Death Differ. 2017 Jun; 24(6): 1063–1078. Published online 2017 Apr 21. doi: 10.1038/cdd.2017.54

PMCID:: PMC5442473

Abstract Article PDF–3.2M

Select item 451724712.

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea

Erin J. Golden, Ana Benito-Gonzalez, Angelika Doetzlhofer

Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29): E3864–E3873. Published online 2015 Jul 2. doi: 10.1073/pnas.1501077112

PMCID:: PMC4517247

Abstract Article PDF–1.9M

Select item 446089513.

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71

Sibylle Mitschka, Thomas Ulas, Tobias Goller, Karin Schneider, Angela Egert, Jérôme Mertens, Oliver Brüstle, Hubert Schorle, Marc Beyer, Kathrin Klee, Jia Xue, Patrick Günther, Kevin Bassler, Joachim L. Schultze, Waldemar Kolanus

Sci Rep. 2015; 5: 11126. Published online 2015 Jun 9. doi: 10.1038/srep11126

PMCID:: PMC4460895

Abstract Article PDF–2.8M

Select item 438298614.

Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain

Elisa Cuevas, Agnieszka Rybak-Wolf, Anna M. Rohde, Duong T. T. Nguyen, F. Gregory Wulczyn

Front Cell Dev Biol. 2015; 3: 20. Published online 2015 Apr 2. doi: 10.3389/fcell.2015.00020

PMCID:: PMC4382986

Abstract Article PDF–3.3M

Select item 407349415.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 396495516.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977