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Select item 108684241.

Glial control of sphingolipid levels sculpts diurnal remodeling of circadian circuits

John P. Vaughen, Emma Theisen, Irma Magaly Rivas-Serna, Andrew B. Berger, Prateek Kalakuntla, Ina Anreiter, Vera C. Mazurak, Tamy Portillo Rodriguez, Joshua D. Mast, Tom Hartl, Ethan O. Perlstein, Richard J. Reimer, M. Thomas Clandinin, Thomas R. Clandinin

Neuron. Author manuscript; available in PMC 2024 Feb 15.

Published in final edited form as: Neuron. 2022 Oct 5; 110(19): 3186–3205.e7. Published online 2022 Aug 11. doi: 10.1016/j.neuron.2022.07.016

PMCID:: PMC10868424

Abstract Article PDF–4.2M

Select item 107349782.

Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease

Magda L. Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L. Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J. Kinghorn

PLoS Genet. 2023 Dec; 19(12): e1011063. Published online 2023 Dec 21. doi: 10.1371/journal.pgen.1011063

PMCID:: PMC10734978

Abstract Article PDF–4.3M

Select item 103323243.

The identification of protein and RNA interactors of the splicing factor Caper in the adult Drosophila nervous system

M. Brandon Titus, Adeline W. Chang, Niko Popitsch, Christopher C. Ebmeier, Jeremy M. Bono, Eugenia C. Olesnicky

Front Mol Neurosci. 2023; 16: 1114857. Published online 2023 Jun 23. doi: 10.3389/fnmol.2023.1114857

PMCID:: PMC10332324

Abstract Article PDF–4.5M

Select item 102317924.

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee, Yarong Li, Duc Duong, Bridget Phillips, Carlos Cruchaga, Genevera I. Allen, Nicholas T. Seyfried, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman

PLoS Genet. 2023 May; 19(5): e1010760. Published online 2023 May 18. doi: 10.1371/journal.pgen.1010760

PMCID:: PMC10231792

Abstract Article PDF–1.9M

Select item 101158385.

Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation

Daria Messelodi, Silvia Strocchi, Salvatore Nicola Bertuccio, Pascale Baden, Valentina Indio, Federico M. Giorgi, Alberto Taddia, Salvatore Serravalle, Sabrina Valente, Alessio di Fonzo, Emanuele Frattini, Roberto Bernardoni, Annalisa Pession, Daniela Grifoni, Michela Deleidi, Annalisa Astolfi, Andrea Pession

Commun Biol. 2023; 6: 431. Published online 2023 Apr 19. doi: 10.1038/s42003-023-04813-2

PMCID:: PMC10115838

Abstract Article PDF–7.6M

Select item 99787936.

Sphingolipids in neurodegenerative diseases

Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J. Bellen

Front Neurosci. 2023; 17: 1137893. Published online 2023 Feb 16. doi: 10.3389/fnins.2023.1137893

PMCID:: PMC9978793

Abstract Article PDF–6.2M

Select item 96326587.

Exploring therapeutic potential of mitophagy modulators using Drosophila models of Parkinson’s disease

Jyotsna Asthana, Bhupendra V. Shravage

Front Aging Neurosci. 2022; 14: 986849. Published online 2022 Oct 19. doi: 10.3389/fnagi.2022.986849

PMCID:: PMC9632658

Abstract Article PDF–1.2M

Select item 93783618.

‘Fly’ing from rare to common neurodegenerative disease mechanisms

Mengqi Ma, Matthew J. Moulton, Shenzhao Lu, Hugo J. Bellen

Trends Genet. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Trends Genet. 2022 Sep; 38(9): 972–984. Published online 2022 Apr 25. doi: 10.1016/j.tig.2022.03.018

PMCID:: PMC9378361

Abstract Article PDF–1.0M

Select item 92788649.

Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia

Liping Wang, Guang Lin, Zhongyuan Zuo, Yarong Li, Seul Kee Byeon, Akhilesh Pandey, Hugo J. Bellen

Sci Adv. 2022 Jul; 8(28): eabn3326. Published online 2022 Jul 13. doi: 10.1126/sciadv.abn3326

PMCID:: PMC9278864

Abstract Article PDF–9.4M

Select item 922130610.

Genes Responsible for H₂S Production and Metabolism Are Involved in Learning and Memory in Drosophila melanogaster

Olga G. Zatsepina, Lyubov N. Chuvakova, Ekaterina A. Nikitina, Alexander P. Rezvykh, Alexey S. Zakluta, Svetlana V. Sarantseva, Nina V. Surina, Alexander L. Ksenofontov, Ludmila A. Baratova, Viktoria Y. Shilova, Michael B. Evgen’ev

Biomolecules. 2022 Jun; 12(6): 751. Published online 2022 May 26. doi: 10.3390/biom12060751

PMCID:: PMC9221306

Abstract Article PDF–3.0M

Select item 865799311.

Glitazone Treatment Rescues Phenotypic Deficits in a Fly Model of Gaucher/Parkinson’s Disease

Oluwanifemi Shola-Dare, Shelby Bailess, Carlos C. Flores, William M. Vanderheyden, Jason R. Gerstner

Int J Mol Sci. 2021 Dec; 22(23): 12740. Published online 2021 Nov 25. doi: 10.3390/ijms222312740

PMCID:: PMC8657993

Abstract Article PDF–3.3M

Select item 827048412.

Loss of UCHL1 rescues the defects related to Parkinson’s disease by suppressing glycolysis

Su Jin Ham, Daewon Lee, Wen Jun Xu, Eunjoo Cho, Sekyu Choi, Soohong Min, Sunghyouk Park, Jongkyeong Chung

Sci Adv. 2021 Jul; 7(28): eabg4574. Published online 2021 Jul 9. doi: 10.1126/sciadv.abg4574

PMCID:: PMC8270484

Abstract Article PDF–7.4M

Select item 800085013.

Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery

Laura Rigon, Concetta De Filippis, Barbara Napoli, Rosella Tomanin, Genny Orso

Biomedicines. 2021 Mar; 9(3): 268. Published online 2021 Mar 7. doi: 10.3390/biomedicines9030268

PMCID:: PMC8000850

Abstract Article PDF–2.8M

Select item 800006614.

The Uncovered Function of the Drosophila GBA1a-Encoded Protein

Or Cabasso, Sumit Paul, Gali Maor, Metsada Pasmanik-Chor, Wouter Kallemeijn, Johannes Aerts, Mia Horowitz

Cells. 2021 Mar; 10(3): 630. Published online 2021 Mar 12. doi: 10.3390/cells10030630

PMCID:: PMC8000066

Abstract Article PDF–5.0M

Select item 799831615.

The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease

Melissa Vos, Christine Klein

Cells. 2021 Mar; 10(3): 579. Published online 2021 Mar 6. doi: 10.3390/cells10030579

PMCID:: PMC7998316

Abstract Article PDF–1.7M

Select item 788866516.

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Kathryn A. Jewett, Ruth E. Thomas, Chi Q. Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F. Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J. Pallanck, Marie Y. Davis

PLoS Genet. 2021 Feb; 17(2): e1008859. Published online 2021 Feb 4. doi: 10.1371/journal.pgen.1008859