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Items: 1 to 20 of 140

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
NUDT16 regulates CtIP PARylation to dictate homologous recombination repair
Zhen Zhang, William E Samsa, Zihua Gong
Nucleic Acids Res. 2024 Apr 24; 52(7): 3761–3777. Published online 2024 Feb 7. doi: 10.1093/nar/gkae064
PMCID:
PMC11039996
AbstractArticlePDF–2.4M
3.
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4
PMCID:
PMC10869800
AbstractArticlePDF–9.3M
4.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
5.
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
Jingwei Liu, Tingting Zhou, Xiang Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Danni Li, Ling Ren, Fei Yi, Ying Zhang, Ziwei Li, Xiwen Wang, Chengsi Deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Songming Lu, Liangzi Cao, Yutong Xiao, Xiaoyu Song, Zhenning Wang, Chengzhong Xing, Liu Cao
Oncogene. 2023; 42(22): 1843–1856. Published online 2023 Apr 20. doi: 10.1038/s41388-023-02667-w
PMCID:
PMC10238270
AbstractArticlePDF–6.2M
6.
SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination
Seo-Yeon Jeong, Gurusamy Hariharasudhan, Min-Ji Kim, Ji-Yeon Lim, Sung Mi Jung, Eun-Ji Choi, In-Youb Chang, Younghoon Kee, Ho Jin You, Jung-Hee Lee
Nucleic Acids Res. 2022 Oct 14; 50(18): 10469–10486. Published online 2022 Sep 26. doi: 10.1093/nar/gkac808
PMCID:
PMC9561274
AbstractArticlePDF–5.7M
7.
The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy
Jiying Wang, Zhaoying Sheng, Zhiyi Dong, Qiongya Wu, Yong Cai
Int J Immunopathol Pharmacol. 2022 Jan-Dec; 36: 03946320221130727. Published online 2022 Sep 29. doi: 10.1177/03946320221130727
PMCID:
PMC9523831
AbstractArticlePDF–2.2M
8.
PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP
Zhiyu Qiu, Shuailin Hao, Shikai Song, Ruiling Zhang, Tingyu Yan, Zhifang Lu, Hailong Wang, Zongchao Jia, Jimin Zheng
Front Cell Dev Biol. 2022; 10: 902403. Published online 2022 Aug 25. doi: 10.3389/fcell.2022.902403
PMCID:
PMC9452783
AbstractArticlePDF–2.7M
9.
The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells
Nicole B. Averbeck, Carina Barent, Burkhard Jakob, Tatyana Syzonenko, Marco Durante, Gisela Taucher-Scholz
Cells. 2022 Aug; 11(16): 2561. Published online 2022 Aug 17. doi: 10.3390/cells11162561
PMCID:
PMC9406464
AbstractArticlePDF–3.1M
10.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
11.
A protein interaction landscape of breast cancer
Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan
Science. Author manuscript; available in PMC 2022 Apr 26.
Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066
PMCID:
PMC9040556
AbstractArticlePDF–2.2M
12.
IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma
Meng Liu, Ying Zhang, Yunzhao Wu, Jin Jin, Yang Cao, Zhixiao Fang, Lou Geng, Li Yang, Miao Yu, Zhilei Bu, Yanjie Ji, Huizhuang Shan, Zhihui Zou, Ligen Liu, Yingying Wang, Youping Zhang, Yin Tong, Hanzhang Xu, Hu Lei, Wei Liu, Fenghou Gao, Yingli Wu
Int J Biol Sci. 2022; 18(6): 2515–2526. Published online 2022 Mar 21. doi: 10.7150/ijbs.70960
PMCID:
PMC8990476
AbstractArticlePDF–22M
13.
RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor
Hella A. Bolck, Sara Przetocka, Roger Meier, Christine von Aesch, Christina Zurfluh, Kay Hänggi, Vincent Spegg, Matthias Altmeyer, Michael Stebler, Simon F. Nørrelykke, Peter Horvath, Alessandro A. Sartori, Antonio Porro
Cells. 2022 Feb; 11(4): 643. Published online 2022 Feb 12. doi: 10.3390/cells11040643
PMCID:
PMC8870135
AbstractArticlePDF–6.1M
14.
Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation
Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley
Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h
PMCID:
PMC8763317
AbstractArticle
15.
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage
John J. Krais, Yifan Wang, Pooja Patel, Jayati Basu, Andrea J. Bernhardy, Neil Johnson
Nat Commun. 2021; 12: 5016. Published online 2021 Aug 18. doi: 10.1038/s41467-021-25346-4
PMCID:
PMC8373961
AbstractArticlePDF–4.1M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model
Jianping Ren, Yan Wu, Ya Wang, Yuqin Zhao, Youhang Li, Shuailin Hao, Lixiu Lin, Shuyuan Zhang, Xingzhi Xu, Hailong Wang
J Biol Chem. 2021 Jan-Jun; 296: 100707. Published online 2021 Apr 24. doi: 10.1016/j.jbc.2021.100707
PMCID:
PMC8164041
AbstractArticlePDF–3.1M
18.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
19.
ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP
Jinhua Han, Li Wan, Guixing Jiang, Liping Cao, Feiyu Xia, Tian Tian, Xiaomei Zhu, Mingjie Wu, Michael S. Y. Huen, Yi Wang, Ting Liu, Jun Huang
Proc Natl Acad Sci U S A. 2021 Mar 23; 118(12): e2022600118. Published online 2021 Mar 15. doi: 10.1073/pnas.2022600118
PMCID:
PMC8000100
AbstractArticlePDF–2.1M
20.
A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity
Aleksandar Zdravković, James M. Daley, Arijit Dutta, Tatsuya Niwa, Yasuto Murayama, Shuji Kanamaru, Kentaro Ito, Takahisa Maki, Bilge Argunhan, Masayuki Takahashi, Hideo Tsubouchi, Patrick Sung, Hiroshi Iwasaki
Proc Natl Acad Sci U S A. 2021 Mar 16; 118(11): e2016287118. Published online 2021 Mar 8. doi: 10.1073/pnas.2016287118
PMCID:
PMC7980430
AbstractArticlePDF–1.2M

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