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Select item 107561431.

A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant

Alistair Jones, Melissa Barker-Haliski, Andrei S. Ilie, Murray B. Herd, Sarah Baxendale, Celia J. Holdsworth, John-Paul Ashton, Marysia Placzek, Bodiabaduge A. P. Jayasekera, Christopher J. A. Cowie, Jeremy J. Lambert, Andrew J. Trevelyan, H. Steve White, Anthony G. Marson, Vincent T. Cunliffe, Graeme J. Sills, Alan Morgan

Epilepsia. Author manuscript; available in PMC 2023 Dec 29.

Published in final edited form as: Epilepsia. 2020 Oct; 61(10): 2106–2118. Published online 2020 Aug 14. doi: 10.1111/epi.16644

PMCID:: PMC10756143

Abstract Article PDF–1.1M

Select item 104694612.

Disruption of fos causes craniofacial anomalies in developing zebrafish

Lorena Maili, Bhavna Tandon, Qiuping Yuan, Simone Menezes, Frankie Chiu, S. Shahrukh Hashmi, Ariadne Letra, George T. Eisenhoffer, Jacqueline T. Hecht

Front Cell Dev Biol. 2023; 11: 1141893. Published online 2023 Aug 16. doi: 10.3389/fcell.2023.1141893

PMCID:: PMC10469461

Abstract Article PDF–2.8M

Select item 104553313.

In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice

Dorota Nieoczym, Nancy Saana Banono, Katarzyna Stępnik, Agnieszka A. Kaczor, Przemysław Szybkowski, Camila Vicencio Esguerra, Wirginia Kukula-Koch, Kinga Gawel

Int J Mol Sci. 2023 Aug; 24(16): 12949. Published online 2023 Aug 18. doi: 10.3390/ijms241612949

PMCID:: PMC10455331

Abstract Article PDF–8.1M

Select item 102841164.

Tris(4-chlorophenyl)methane (TCPM) and tris(4-chlorophenyl)methanol (TCPMOH) disrupt pancreatic organogenesis and gene expression in zebrafish embryos

Peyton W. Wilson, Christine Cho, Nicholas Allsing, Saleha Khanum, Pria Bose, Ava Grubschmidt, Karilyn E. Sant

Birth Defects Res. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Birth Defects Res. 2023 Mar 1; 115(4): 458–473. Published online 2022 Dec 5. doi: 10.1002/bdr2.2132

PMCID:: PMC10284116

Abstract Article PDF–954K

Select item 102733465.

Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear

Davide Baldera, Sarah Baxendale, Nicholas J. van Hateren, Mar Marzo, Emily Glendenning, Fan‐Suo Geng, Kazutomo Yokoya, Robert D. Knight, Tanya T. Whitfield

J Anat. 2023 Jul; 243(1): 78–89. Published online 2023 Feb 6. doi: 10.1111/joa.13845

PMCID:: PMC10273346

Abstract Article PDF–5.7M

Select item 102445136.

Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways

Sarah E. Grabinski, Dhwani Parsana, Brian D. Perkins

Front Mol Neurosci. 2023; 16: 1148840. Published online 2023 May 24. doi: 10.3389/fnmol.2023.1148840

PMCID:: PMC10244513

Abstract Article PDF–2.1M

Select item 102184247.

Simple Coumarins from Peucedanum luxurians Fruits: Evaluation of Anxiolytic Activity and Influence on Gene Expression Related to Anxiety in Zebrafish Model

Jarosław Widelski, Natalia Kasica, Monika Maciąg, Simon Vlad Luca, Barbara Budzyńska, Dafina Fondai, Piotr Podlasz, Krystyna Skalicka-Woźniak

Int J Mol Sci. 2023 May; 24(10): 8693. Published online 2023 May 12. doi: 10.3390/ijms24108693

PMCID:: PMC10218424

Abstract Article PDF–4.8M

Select item 101881128.

linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells

Valerie A Tornini, Liyun Miao, Ho-Joon Lee, Timothy Gerson, Sarah E Dube, Valeria Schmidt, François Kroll, Yin Tang, Katherine Du, Manik Kuchroo, Charles E Vejnar, Ariel Alejandro Bazzini, Smita Krishnaswamy, Jason Rihel, Antonio J Giraldez

eLife. 2023; 12: e82249. Published online 2023 May 16. doi: 10.7554/eLife.82249

PMCID:: PMC10188112

Abstract Article PDF–5.3M

Select item 101080349.

Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury

Daniel A. Zuppo, Maria A. Missinato, Lucas Santana-Santos, Guang Li, Panayiotis V. Benos, Michael Tsang

Development. 2023 Mar 15; 150(6): dev201163. Published online 2023 Mar 14. doi: 10.1242/dev.201163

PMCID:: PMC10108034

Abstract Article

Select item 996115410.

Dysfunction of Prkcaa Links Social Behavior Defects with Disturbed Circadian Rhythm in Zebrafish

Han Hu, Yong Long, Guili Song, Shaoxiong Chen, Zhicheng Xu, Qing Li, Zhengli Wu

Int J Mol Sci. 2023 Feb; 24(4): 3849. Published online 2023 Feb 14. doi: 10.3390/ijms24043849

PMCID:: PMC9961154

Abstract Article PDF–12M

Select item 991643311.

Evaluation of the Antiseizure Activity of Endemic Plant Halfordia kendack Guillaumin and Its Main Constituent, Halfordin, on a Zebrafish Pentylenetetrazole (PTZ)-Induced Seizure Model

Adrianna Skiba, Ewelina Kozioł, Simon Vlad Luca, Barbara Budzyńska, Piotr Podlasz, Wietske Van Der Ent, Elham Shojaeinia, Camila V. Esguerra, Mohammed Nour, Laurence Marcourt, Jean-Luc Wolfender, Krystyna Skalicka-Woźniak

Int J Mol Sci. 2023 Feb; 24(3): 2598. Published online 2023 Jan 30. doi: 10.3390/ijms24032598

PMCID:: PMC9916433

Abstract Article PDF–1.4M

Select item 981027212.

HRG-9 homologues regulate haem trafficking from haem-enriched compartments

Fengxiu Sun, Zhenzhen Zhao, Mathilda M. Willoughby, Shuaiqi Shen, Yu Zhou, Yiyan Shao, Jing Kang, Yongtian Chen, Mengying Chen, Xiaojing Yuan, Iqbal Hamza, Amit R. Reddi, Caiyong Chen

Nature. Author manuscript; available in PMC 2023 Apr 19.

Published in final edited form as: Nature. 2022 Oct; 610(7933): 768–774. Published online 2022 Oct 19. doi: 10.1038/s41586-022-05347-z

Correction in:: Nature. 2024 Dec 12

PMCID:: PMC9810272

Abstract Article PDF–3.6M

Select item 956976313.

Understanding the Function and Mechanism of Zebrafish Tmem39b in Regulating Cold Resistance

Renyan Liu, Yong Long, Ran Liu, Guili Song, Qing Li, Huawei Yan, Zongbin Cui

Int J Mol Sci. 2022 Oct; 23(19): 11442. Published online 2022 Sep 28. doi: 10.3390/ijms231911442

PMCID:: PMC9569763

Abstract Article PDF–4.8M

Select item 945634114.

Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish

Khadizatul Kubra, Gurveer K. Gaddu, Clifford Liongue, Somayyeh Heidary, Alister C. Ward, Amardeep S. Dhillon, Faiza Basheer

Int J Mol Sci. 2022 Sep; 23(17): 10098. Published online 2022 Sep 3. doi: 10.3390/ijms231710098

PMCID:: PMC9456341

Abstract Article PDF–5.0M

Select item 935258815.

Visual recognition of social signals by a tectothalamic neural circuit

Johannes M. Kappel, Dominique Förster, Katja Slangewal, Inbal Shainer, Fabian Svara, Joseph C. Donovan, Shachar Sherman, Michał Januszewski, Herwig Baier, Johannes Larsch

Nature. 2022; 608(7921): 146–152. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04925-5

PMCID:: PMC9352588

Abstract Article PDF–10M

Select item 922771716.

Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish

Karin Tuschl, Richard J. White, Chintan Trivedi, Leonardo E. Valdivia, Stephanie Niklaus, Isaac H. Bianco, Chris Dadswell, Ramón González-Méndez, Ian M. Sealy, Stephan C. F. Neuhauss, Corinne Houart, Jason Rihel, Stephen W. Wilson, Elisabeth M. Busch-Nentwich

Dis Model Mech. 2022 Jun 1; 15(6): dmm044594. Published online 2022 Jun 15. doi: 10.1242/dmm.044594

PMCID:: PMC9227717

Abstract Article

Select item 917296817.

Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery

Yifan Zhang, Lise Heylen, Michèle Partoens, James D. Mills, Rafal M. Kaminski, Patrice Godard, Michel Gillard, Peter A. M. de Witte, Aleksandra Siekierska

Front Mol Neurosci. 2022; 15: 881933. Published online 2022 May 24. doi: 10.3389/fnmol.2022.881933

PMCID:: PMC9172968

Abstract Article PDF–3.6M

Select item 911727918.

Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

Paige Whyte-Fagundes, Daria Taskina, Nickie Safarian, Christiane Zoidl, Peter L. Carlen, Logan W. Donaldson, Georg R. Zoidl

Commun Biol. 2022; 5: 472. Published online 2022 May 18. doi: 10.1038/s42003-022-03356-2

PMCID:: PMC9117279

Abstract Article PDF–6.2M

Select item 910750619.

Enhancer selection dictates gene expression responses in remote organs during tissue regeneration

Fei Sun, Jianhong Ou, Adam R. Shoffner, Yu Luan, Hongbo Yang, Lingyun Song, Alexias Safi, Jingli Cao, Feng Yue, Gregory E. Crawford, Kenneth D. Poss

Nat Cell Biol. Author manuscript; available in PMC 2022 Nov 5.

Published in final edited form as: Nat Cell Biol. 2022 May; 24(5): 685–696. Published online 2022 May 5. doi: 10.1038/s41556-022-00906-y

PMCID:: PMC9107506

Abstract Article PDF–6.7M

Select item 895636020.

Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish

Sheng-Jia Lin, Barbara Vona, Patricia G Barbalho, Rauan Kaiyrzhanov, Reza Maroofian, Cassidy Petree, Mariasavina Severino, Valentina Stanley, Pratishtha Varshney, Paulina Bahena, Fatema Alzahrani, Amal Alhashem, Alistair T Pagnamenta, Gudrun Aubertin, Juvianee I Estrada-Veras, Héctor Adrián Díaz Hernández, Neda Mazaheri, Andrea Oza, Jenny Thies, Deborah L Renaud, Sanmati Dugad, Jennifer McEvoy, Tipu Sultan, Lynn S Pais, Brahim Tabarki, Daniel Villalobos-Ramirez, Aboulfazl Rad, Genomics England Research Consortium, Hamid Galehdari, Farah Ashrafzadeh, Afsaneh Sahebzamani, Kolsoum Saeidi, Erin Torti, Houda Z Elloumi, Sara Mora, Timothy B Palculict, Hui Yang, Jonathan D Wren, Ben Fowler, Manali Joshi, Martine Behra, Shawn M Burgess, Swapan K Nath, Michael G Hanna, Margaret Kenna, J Lawrence Merritt, 2nd, Henry Houlden, Ehsan Ghayoor Karimiani, Maha S Zaki, Thomas Haaf, Fowzan S Alkuraya, Joseph G Gleeson, Gaurav K Varshney

Genet Med. Author manuscript; available in PMC 2022 Mar 25.

Published in final edited form as: Genet Med. 2021 Oct; 23(10): 1933–1943. Published online 2021 Jun 25. doi: 10.1038/s41436-021-01239-1

PMCID:: PMC8956360

Abstract Article PDF–2.7M

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