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Items: 1 to 20 of 94

1.
Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA
Kanal Elamparithi Balu, Mitchell Gulkis, Danah Almohdar, Melike Çağlayan
J Biol Chem. 2024 May; 300(5): 107216. Published online 2024 Mar 24. doi: 10.1016/j.jbc.2024.107216
PMCID:
PMC11035063
AbstractArticlePDF–3.4M
2.
The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese
SHANG-MIAO CHANG, YA-CHEN YANG, GUAN-LIANG CHEN, LI-HSIOU CHEN, TE-CHUN SHEN, YEN-FENG LIU, YUN-CHI WANG, CHIA-WEN TSAI, TE-CHUN HSIA, DA-TIAN BAU, WEN-SHIN CHANG
In Vivo. 2023 Jul-Aug; 37(4): 1504–1510. Published online 2023 Jul 3. doi: 10.21873/invivo.13235
PMCID:
PMC10347960
AbstractArticlePDF–131K
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1
Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Pierre-Antoine Defossez, Alan E. Tomkinson
Sci Rep. 2023; 13: 4363. Published online 2023 Mar 16. doi: 10.1038/s41598-023-31367-4
PMCID:
PMC10020546
AbstractArticlePDF–3.7M
5.
Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity
Justin R McNally, Amanda M Ames, Suzanne J Admiraal, Patrick J O’Brien
Nucleic Acids Res. 2023 Jan 25; 51(2): 796–805. Published online 2023 Jan 10. doi: 10.1093/nar/gkac1263
PMCID:
PMC9881130
AbstractArticlePDF–1.9M
6.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
7.
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB
Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan
EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698
PMCID:
PMC9433938
AbstractArticlePDF–9.3M
8.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
9.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
10.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
11.
Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation
Yuzheng Zhou, Rong Zheng, Sixu Liu, Cyrollah Disoma, Ashuai Du, Shiqin Li, Zongpeng Chen, Zijun Dong, Yongxing Zhang, Sijia Li, Pinjia Liu, Aroona Razzaq, Xuan Chen, Yujie Liao, Siyi Tao, Yuxin Liu, Lunan Xu, Qianjun Zhang, Jian Peng, Xu Deng, Shanni Li, Taijiao Jiang, Zanxian Xia
J Biol Chem. 2022 Feb; 298(2): 101584. Published online 2022 Jan 13. doi: 10.1016/j.jbc.2022.101584
PMCID:
PMC8755419
AbstractArticlePDF–3.5M
12.
Human DNA ligases in replication and repair
Annahita Sallmyr, Ishtiaque Rashid, Seema Khattri Bhandari, Tasmin Naila, Alan E. Tomkinson
DNA Repair (Amst) Author manuscript; available in PMC 2022 Jan 4.
Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102908. doi: 10.1016/j.dnarep.2020.102908
PMCID:
PMC8727047
AbstractArticlePDF–1.5M
13.
Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation
Yoshihiro Matsumoto, Rhys C. Brooks, Aleksandr Sverzhinsky, John M. Pascal, Alan E. Tomkinson
J Mol Biol. Author manuscript; available in PMC 2022 Jan 4.
Published in final edited form as: J Mol Biol. 2020 Dec 4; 432(24): 166698. Published online 2020 Nov 4. doi: 10.1016/j.jmb.2020.10.032
PMCID:
PMC8727043
AbstractArticlePDF–2.5M
14.
Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers
Reem Ali, Muslim Alabdullah, Mashael Algethami, Adel Alblihy, Islam Miligy, Ahmed Shoqafi, Katia A. Mesquita, Tarek Abdel-Fatah, Stephen YT Chan, Pei Wen Chiang, Nigel P Mongan, Emad A Rakha, Alan E Tomkinson, Srinivasan Madhusudan
Theranostics. 2021; 11(17): 8350–8361. Published online 2021 Jul 25. doi: 10.7150/thno.51456
PMCID:
PMC8344016
AbstractArticlePDF–2.5M
15.
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα
Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz
iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686
PMCID:
PMC8220391
AbstractArticlePDF–4.4M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair
Pradnya Kamble, Kalen Hall, Mahesh Chandak, Qun Tang, Melike Çağlayan
J Biol Chem. 2021 Jan-Jun; 296: 100427. Published online 2021 Feb 16. doi: 10.1016/j.jbc.2021.100427
PMCID:
PMC8024709
AbstractArticlePDF–4.3M
18.
LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency
Thomas J Jurkiw, Percy P Tumbale, Matthew J Schellenberg, Charlotte Cunningham-Rundles, R Scott Williams, Patrick J O’Brien
Nucleic Acids Res. 2021 Feb 22; 49(3): 1619–1630. Published online 2021 Jan 14. doi: 10.1093/nar/gkaa1297
PMCID:
PMC7897520
AbstractArticlePDF–11M
19.
DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage
Qun Tang, Pradnya Kamble, Melike Çağlayan
Mutagenesis. 2020 Sep; 35(5): 391–404. Published online 2020 Sep 11. doi: 10.1093/mutage/geaa023
PMCID:
PMC7846189
AbstractArticlePDF–3.9M
20.
The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells
Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson, Scott B. Rothbart
Epigenetics Chromatin. 2020; 13: 44. Published online 2020 Oct 23. doi: 10.1186/s13072-020-00366-4
PMCID:
PMC7585203
AbstractArticlePDF–5.8M

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