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Items: 1 to 20 of 208

1.
SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner
Yong Du, Jiaqing He, Yanni Xu, Xun Wu, Hongbo Cheng, Jiegang Yu, Xiaoliang Wang, Yaqing An, Yang Wu, Wei Guo
J Transl Med. 2024; 22: 788. Published online 2024 Aug 25. doi: 10.1186/s12967-024-05566-0
PMCID:
PMC11346289
AbstractArticlePDF–7.3M
2.
Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
Jan Frohlich, Niccolò Liorni, Manuel Mangoni, Gabriela Lochmanová, Pavlína Pírek, Nikola Kaštánková, Pille Pata, Jan Kucera, George N. Chaldakov, Anton B. Tonchev, Illar Pata, Vera Gorbunova, Eric Leire, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Clin Epigenetics. 2024; 16: 96. Published online 2024 Jul 20. doi: 10.1186/s13148-024-01710-1
PMCID:
PMC11265064
AbstractArticlePDF–3.4M
3.
X‐Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells
Zhuo Yang, Shaojun Li, Chuan Zhao, Zongzheng Zhao, Juan Tan, Lu Zhang, Yuanqing Huang
Immun Inflamm Dis. 2024 Jul; 12(7): e1301. Published online 2024 Jul 5. doi: 10.1002/iid3.1301
PMCID:
PMC11225082
AbstractArticlePDF–2.8M
4.
Expression analysis and biological regulation of silencing regulatory protein 6 (SIRT6) in cutaneous squamous cell carcinoma
Sai Chen, Hongxia Chen, Xu Wang, Dongmei Zhang, Li Zhang, Jiawei Cheng, Qi Zhang, Zhixiang Hua, Xu Miao, Jian Shi
An Bras Dermatol. 2024 Jul-Aug; 99(4): 535–545. Published online 2024 Mar 27. doi: 10.1016/j.abd.2023.08.010
PMCID:
PMC11220918
AbstractArticlePDF–2.5M
5.
MiR-34a-5p suppresses cutaneous squamous cell carcinoma progression by targeting SIRT6
Sai Chen, Muxing Yuan, Hongxia Chen, Tong Wu, Tianqi Wu, Dongmei Zhang, Xu Miao, Jian Shi
Arch Dermatol Res. 2024; 316(6): 299. Published online 2024 May 31. doi: 10.1007/s00403-024-03106-w
PMCID:
PMC11143063
AbstractArticlePDF–3.1M
6.
Exosomes derived from adipose tissue-derived stem cells alleviated H2O2-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway
Yan Li, Yujie Xiao, Yage Shang, Chaolei Xu, Chao Han, Dahai Hu, Juntao Han, Hongtao Wang
Cell Biol Toxicol. 2024; 40(1): 39. Published online 2024 May 25. doi: 10.1007/s10565-024-09881-6
PMCID:
PMC11126451
AbstractArticlePDF–6.5M
7.
Roles of SIRT6 in kidney disease: a novel therapeutic target
Xueyan Yang, Jun Feng, Wei Liang, Zijing Zhu, Zhaowei Chen, Jijia Hu, Dingping Yang, Guohua Ding
Cell Mol Life Sci. 2022 Jan; 79(1): 53. Published online 2021 Dec 24. doi: 10.1007/s00018-021-04061-9
PMCID:
PMC11072764
AbstractArticlePDF–1.6M
8.
Hepatic Sirt6 activation abrogates acute liver failure
Jinque Luo, Huan Liu, Yanni Xu, Nanhui Yu, Rebbeca A. Steiner, Xiaoqian Wu, Shuyi Si, Zheng Gen Jin
Cell Death Dis. 2024 Apr; 15(4): 283. Published online 2024 Apr 22. doi: 10.1038/s41419-024-06537-5
PMCID:
PMC11035560
AbstractArticlePDF–7.7M
9.
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
Ekaterina Smirnova, Emmanuelle Bignon, Patrick Schultz, Gabor Papai, Adam Ben Shem
eLife. 2024; 12: RP87989. Published online 2024 Feb 28. doi: 10.7554/eLife.87989
PMCID:
PMC10942634
AbstractArticlePDF–8.9M
10.
Downregulation of SIRT6 and NMNAT2 is associated with proliferative diabetic retinopathy
Hui Chen, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen
Mol Vis. 2023; 29: 160–168. Published online 2023 Oct 2.
PMCID:
PMC10784219
AbstractArticlePDF–1.0M
11.
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, Brian O. Diekman
Aging (Albany NY) 2023 Dec 15; 15(23): 13628–13645. Published online 2023 Dec 9. doi: 10.18632/aging.205394
PMCID:
PMC10756124
AbstractArticlePDF–2.3M
12.
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
Jingyun Quan, Xiaoxia Wen, Guomei Su, Yu Zhong, Tong Huang, Zhilin Xiong, Jiewen Huang, Yingying Lv, Shihai Li, Shuhua Luo, Chaole Luo, Xin Cai, Xianwen Lai, Yuanyuan Xiang, Song Guo Zheng, Yiming Shao, Haitao Lin, Xiao Gao, Jing Tang, Tianwen Lai
Nat Commun. 2023; 14: 8525. Published online 2023 Dec 22. doi: 10.1038/s41467-023-44179-x
PMCID:
PMC10746710
AbstractArticlePDF–5.8M
13.
SIRT6 promotes metastasis and relapse in HER2-positive breast cancer
Cristina Andreani, Caterina Bartolacci, Giuseppe Persico, Francesca Casciaro, Stefano Amatori, Mirco Fanelli, Marco Giorgio, Mirco Galié, Daniele Tomassoni, Junbiao Wang, Xiaoting Zhang, Gregory Bick, Roberto Coppari, Cristina Marchini, Augusto Amici
Sci Rep. 2023; 13: 22000. Published online 2023 Dec 12. doi: 10.1038/s41598-023-49199-7
PMCID:
PMC10713583
AbstractArticlePDF–12M
14.
SIRT6’s function in controlling the metabolism of lipids and glucose in diabetic nephropathy
Ying Wang, Tongtong Liu, Yuzi Cai, Weijing Liu, Jing Guo
Front Endocrinol (Lausanne) 2023; 14: 1244705. Published online 2023 Oct 9. doi: 10.3389/fendo.2023.1244705
PMCID:
PMC10591331
AbstractArticlePDF–1.9M
15.
Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged
Young Jae Moon, Baoning Cui, Se-Young Cho, Jae Won Hwang, Hee-Chung Chung, Joseph Kwon, Duwoon Kim, Kyu Yun Jang, Jung Ryul Kim, Sung Il Wang
Cells. 2023 Aug; 12(16): 2035. Published online 2023 Aug 10. doi: 10.3390/cells12162035
PMCID:
PMC10453227
AbstractArticlePDF–1.9M
16.
Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis
Yingdong Zhu, Shuwei Hu, Xiaoli Pan, Raja Gopoju, Fathima N. Cassim Bawa, Liya Yin, Yanyong Xu, Yanqiao Zhang
Cells. 2023 Aug; 12(15): 2009. Published online 2023 Aug 5. doi: 10.3390/cells12152009
PMCID:
PMC10417046
AbstractArticlePDF–3.5M
17.
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases
Nithya Kartha, Jessica E. Gianopulos, Zachary Schrank, Sarah M. Cavender, Stephanie Dobersch, Bryan D. Kynnap, Adrianne Wallace-Povirk, Cynthia L. Wladyka, Juan F. Santana, Jaeseung C. Kim, Angela Yu, Caroline M. Bridgwater, Kathrin Fuchs, Sarah Dysinger, Aaron E. Lampano, Faiyaz Notta, David H. Price, Andrew C. Hsieh, Sunil R. Hingorani, Sita Kugel
Sci Transl Med. Author manuscript; available in PMC 2023 Jul 7.
Published in final edited form as: Sci Transl Med. 2023 May 3; 15(694): eabn9674. Published online 2023 May 3. doi: 10.1126/scitranslmed.abn9674
PMCID:
PMC10327536
AbstractArticlePDF–2.8M
18.
SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence
Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv, Xiaoqiang Tang, Zi-Yu Wei, Fang Yao, Han-Shi Xu, Yi-Nan Chen, Xiao-Man Wang, Hui-Yu Wang, He-Ping Wang, Zhu-Qin Zhang, Xiang Zhao, De-Long Hao, Li-Hong Sun, Zhou Zhou, Li Wang, Hou-Zao Chen, De-Pei Liu
Signal Transduct Target Ther. 2023; 8: 255. Published online 2023 Jul 3. doi: 10.1038/s41392-023-01456-x
PMCID:
PMC10315397
AbstractArticlePDF–8.0M
19.
The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms
Adrianna Dzidek, Olga Czerwińska-Ledwig, Małgorzata Żychowska, Wanda Pilch, Anna Piotrowska
Int J Mol Sci. 2023 Jun; 24(11): 9655. Published online 2023 Jun 2. doi: 10.3390/ijms24119655
PMCID:
PMC10253323
AbstractArticlePDF–1.6M
20.
More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation: SIRT6-mediated ACSL5 deacetylation regulating FFA metabolism
Shuoshuo Li, Zengqiang Yuan
Acta Biochim Biophys Sin (Shanghai) 2023 Mar; 55(3): 525–527. Published online 2023 Mar 6. doi: 10.3724/abbs.2023030
PMCID:
PMC10160229
ArticlePDF–197K

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