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Select item 110917071.

Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation

Maoxiong Wu, Jing Tan, Zhengyu Cao, Yangwei Cai, Zhaoqi Huang, Zhiteng Chen, Wanbing He, Xiao Liu, Yuan Jiang, Qingyuan Gao, Bingqing Deng, Jingfeng Wang, Woliang Yuan, Haifeng Zhang, Yangxin Chen

Redox Biol. 2024 Jul; 73: 103184. Published online 2024 May 5. doi: 10.1016/j.redox.2024.103184

PMCID:: PMC11091707

Abstract Article PDF–14M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108230653.

Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice

Yufei Wei, Xinhuan Wang, Zhihua Ma, Pan Xiang, Gaoao Liu, Bin Yin, Lin Hou, Pengcheng Shu, Wei Liu, Xiaozhong Peng

iScience. 2024 Feb 16; 27(2): 108706. Published online 2023 Dec 9. doi: 10.1016/j.isci.2023.108706

PMCID:: PMC10823065

Abstract Article PDF–8.1M

Select item 107580934.

Can Wei, Meixin Shi, Shiyun Dong, Zhitao Li, Bingbing Zhao, Dan Liu, Guopeng Li, Jie Cen, Ligen Yu, Xiao Liang, Lili Shi

Int J Biol Sci. 2024; 20(2): 585–605. Published online 2024 Jan 1. doi: 10.7150/ijbs.83306

PMCID:: PMC10758093

Abstract Article PDF–11M

Select item 104682695.

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin

PamelaSara E. Head, Sangho Myung, Yong Chen, Jessica L. Schneller, Cindy Wang, Nicholas Duncan, Pauline Hoffman, David Chang, Abigael Gebremariam, Marjan Gucek, Irini Manoli, Charles P. Venditti

Sci Transl Med. Author manuscript; available in PMC 2023 Aug 30.

Published in final edited form as: Sci Transl Med. 2022 May 25; 14(646): eabn4772. Published online 2022 May 25. doi: 10.1126/scitranslmed.abn4772

PMCID:: PMC10468269

Abstract Article PDF–2.6M

Select item 103633996.

In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions

Joanna Bons, Jacob Rose, Ran Zhang, Jordan B Burton, Christopher Carrico, Eric Verdin, Birgit Schilling

Proteomics. Author manuscript; available in PMC 2023 Jul 23.

Published in final edited form as: Proteomics. 2023 Feb; 23(3-4): e2100371. Published online 2022 Dec 18. doi: 10.1002/pmic.202100371

PMCID:: PMC10363399

Abstract Article PDF–2.0M

Select item 99963707.

The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease

Judy Baek, Kelli Sas, Chenchen He, Viji Nair, William Giblin, Ayaka Inoki, Hongyu Zhang, Yang Yingbao, Jeffrey Hodgin, Robert G. Nelson, Frank C. Brosius, III, Matthias Kretzler, Paul M. Stemmer, David B. Lombard, Subramaniam Pennathur

J Biol Chem. 2023 Mar; 299(3): 102960. Published online 2023 Feb 2. doi: 10.1016/j.jbc.2023.102960

PMCID:: PMC9996370

Abstract Article PDF–2.7M

Select item 99850528.

Histone malonylation is regulated by SIRT5 and KAT2A

Ran Zhang, Joanna Bons, Grace Scheidemantle, Xiaojing Liu, Olga Bielska, Chris Carrico, Jacob Rose, Indra Heckenbach, Morten Scheibye-Knudsen, Birgit Schilling, Eric Verdin

iScience. 2023 Mar 17; 26(3): 106193. Published online 2023 Feb 13. doi: 10.1016/j.isci.2023.106193

PMCID:: PMC9985052

Abstract Article PDF–3.8M

Select item 98982649.

Jianxin Mao, Di Wang, Dong Wang, Qi Wu, Qiliang Shang, Chu Gao, Huanbo Wang, Han Wang, Mu Du, Pandi Peng, Haoruo Jia, Xiaolong Xu, Jie Wang, Liu Yang, Zhuojing Luo

Exp Mol Med. 2023 Jan; 55(1): 253–268. Published online 2023 Jan 18. doi: 10.1038/s12276-023-00928-y

PMCID:: PMC9898264

Abstract Article PDF–9.1M

Select item 975327410.

Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1

Qian Xia, Shuai Gao, Tangrui Han, Meng Mao, Gaofeng Zhan, Yonghong Wang, Xing Li

J Neuroinflammation. 2022; 19: 301. Published online 2022 Dec 14. doi: 10.1186/s12974-022-02665-x

PMCID:: PMC9753274

Abstract Article PDF–11M

Select item 944230011.

Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis

Pengbo Yao, Taiqi Chen, Peng Jiang, Li Li, Wenjing Du

EMBO Rep. 2022 Sep; 23(9): e54391. Published online 2022 Jun 30. doi: 10.15252/embr.202154391

PMCID:: PMC9442300

Abstract Article PDF–5.2M

Select item 929397612.

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

Angela H. Guo, Rachael Baliira, Mary E. Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S. Goldsmith, Shaday Michan, Norma J. Davis, Merissa W. Maccani, Sharlene M. Day, David A. Sinclair, Matthew J. Brody, Costas A. Lyssiotis, Adam B. Stein, David B. Lombard

Sci Rep. 2022; 12: 12258. Published online 2022 Jul 18. doi: 10.1038/s41598-022-16506-7

PMCID:: PMC9293976

Abstract Article PDF–3.0M

Select item 898994813.

Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage

Xing Liu, Fangjing Rong, Jinhua Tang, Chunchun Zhu, Xiaoyun Chen, Shuke Jia, Zixuan Wang, Xueyi Sun, Hongyan Deng, Huangyuan Zha, Gang Ouyang, Wuhan Xiao

Cell Death Differ. 2022 Apr; 29(4): 722–736. Published online 2021 Oct 12. doi: 10.1038/s41418-021-00886-w

PMCID:: PMC8989948

Abstract Article PDF–6.0M

Select item 896915414.

Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

Dhaval P. Bhatt, C. Allie Mills, Kristin A. Anderson, Bárbara J. Henriques, Tânia G. Lucas, Sara Francisco, Juan Liu, Olga R. Ilkayeva, Alexander E. Adams, Shreyas R. Kulkarni, Donald S. Backos, Michael B. Major, Paul A. Grimsrud, Cláudio M. Gomes, Matthew D. Hirschey

J Biol Chem. 2022 Apr; 298(4): 101723. Published online 2022 Feb 12. doi: 10.1016/j.jbc.2022.101723

PMCID:: PMC8969154

Abstract Article PDF–2.8M

Select item 880473615.

Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

Shouan Zhu, Albert Batushansky, Anita Jopkiewicz, Dawid Makosa, Kenneth M. Humphries, Holly Van Remmen, Timothy M. Griffin

Cartilage. 2021 Dec; 13(2 Suppl): 1185S–1199S. Published online 2021 Feb 11. doi: 10.1177/1947603521993209

PMCID:: PMC8804736

Abstract Article PDF–1.4M

Select item 871072616.

Sirtuin 5 is Dispensable for CD8⁺ T Cell Effector and Memory Differentiation

Qianqian Duan, Jiying Ding, Fangfang Li, Xiaowei Liu, Yunan Zhao, Hongxiu Yu, Yong Liu, Lianjun Zhang

Front Cell Dev Biol. 2021; 9: 761193. Published online 2021 Dec 13. doi: 10.3389/fcell.2021.761193

PMCID:: PMC8710726

Abstract Article PDF–3.6M

Select item 854677917.

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-induced Pancreatic Cancer Progression

Tuo Hu, Surendra K Shukla, Enza Vernucci, Chunbo He, Dezhen Wang, Ryan J King, Kanupriya Jha, Kasturi Siddhanta, Nicholas J Mullen, Kuldeep S Attri, Divya Murthy, Nina V Chaika, Ravi Thakur, Scott E Mulder, Camila G Pacheco, Xiao Fu, Robin R High, Fang Yu, Audrey Lazenby, Clemens Steegborn, Ping Lan, Kamiya Mehla, Dante Rotili, Sarika Chaudhary, Sergio Valente, Marco Tafani, Antonello Mai, Johan Auwerx, Eric Verdin, David Tuveson, Pankaj K Singh

Gastroenterology. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Gastroenterology. 2021 Nov; 161(5): 1584–1600. Published online 2021 Jul 8. doi: 10.1053/j.gastro.2021.06.045

PMCID:: PMC8546779

Abstract Article PDF–3.6M

Select item 851387118.

The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation

Yuxun Zhang, Eric Goetzman

PLoS One. 2021; 16(10): e0256619. Published online 2021 Oct 13. doi: 10.1371/journal.pone.0256619

PMCID:: PMC8513871

Abstract Article PDF–1.1M

Select item 821059619.

Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses

Xingying He, Tianliang Li, Kewei Qin, Shiyuan Luo, Zhenjie Li, Qingqing Ji, Honghao Song, Huyang He, Hao Tang, Chaofeng Han, Hongjiao Li, Yan Luo

Theranostics. 2021; 11(15): 7235–7246. Published online 2021 May 24. doi: 10.7150/thno.52934

PMCID:: PMC8210596

Abstract Article PDF–1.7M

Select item 820346520.

The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

William Giblin, Lauren Bringman-Rodenbarger, Angela H. Guo, Surinder Kumar, Alexander C. Monovich, Ahmed M. Mostafa, Mary E. Skinner, Michelle Azar, Ahmed S.A. Mady, Carolina H. Chung, Namrata Kadambi, Keith-Allen Melong, Ho-Joon Lee, Li Zhang, Peter Sajjakulnukit, Sophie Trefely, Erika L. Varner, Sowmya Iyer, Min Wang, James S. Wilmott, H. Peter Soyer, Richard A. Sturm, Antonia L. Pritchard, Aleodor A. Andea, Richard A. Scolyer, Mitchell S. Stark, David A. Scott, Douglas R. Fullen, Marcus W. Bosenberg, Sriram Chandrasekaran, Zaneta Nikolovska-Coleska, Monique E. Verhaegen, Nathaniel W. Snyder, Miguel N. Rivera, Andrei L. Osterman, Costas A. Lyssiotis, David B. Lombard

J Clin Invest. 2021 Jun 15; 131(12): e138926. Published online 2021 Jun 15. doi: 10.1172/JCI138926

PMCID:: PMC8203465

Abstract Article PDF–8.7M

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