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Select item 78495531.

Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

Joshua H. Bourne, Martina Colicchia, Ying Di, Eleyna Martin, Alexander Slater, Lubka T. Roumenina, Jordan D. Dimitrov, Steve P. Watson, Julie Rayes

Haematologica. 2021 Feb 1; 106(2): 626–629. Published online 2020 Apr 30. doi: 10.3324/haematol.2020.246488

PMCID:: PMC7849553

Article PDF–705K

Select item 72648452.

Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling

Alexey A. Martyanov, Fedor A. Balabin, Joanne L. Dunster, Mikhail A. Panteleev, Jonathan M. Gibbins, Anastasia N. Sveshnikova

Biophys J. 2020 Jun 2; 118(11): 2641–2655. Published online 2020 Apr 29. doi: 10.1016/j.bpj.2020.04.023

PMCID:: PMC7264845

Abstract Article PDF–3.7M

Select item 63079363.

Functional significance of the platelet immune receptors GPVI and CLEC-2

Julie Rayes, Steve P. Watson, Bernhard Nieswandt

J Clin Invest. 2019 Jan 2; 129(1): 12–23. Published online 2019 Jan 2. doi: 10.1172/JCI122955

PMCID:: PMC6307936

Abstract Article PDF–8.4M

Select item 55828444.

G_q pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets

Rachit Badolia, Vaishali Inamdar, Bhanu Kanth Manne, Carol Dangelmaier, Johannes A. Eble, Satya P. Kunapuli

J Biol Chem. 2017 Sep 1; 292(35): 14516–14531. Published online 2017 Jul 13. doi: 10.1074/jbc.M117.791012

PMCID:: PMC5582844

Abstract Article PDF–4.8M

Select item 53253935.

High CLEC-2 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Qilai Long, Jiejie Xu, Jianming Guo

Oncotarget. 2016 Sep 27; 7(39): 63661–63668. Published online 2016 Aug 25. doi: 10.18632/oncotarget.11606

PMCID:: PMC5325393

Abstract Article PDF–4.6M

Select item 50133156.

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family

Xu Li, Kim My Tran, Kathryn E. Aziz, Alexey V. Sorokin, Junjie Chen, Wenqi Wang

Mol Cell Proteomics. 2016 Sep; 15(9): 3030–3044. Published online 2016 Jul 18. doi: 10.1074/mcp.M116.060277

PMCID:: PMC5013315

Abstract Article PDF–3.2M

Select item 47372307.

Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β

A. J. Moroi, S. P. Watson

J Thromb Haemost. 2015 Jun; 13(6): 1139–1150. Published online 2015 May 9. doi: 10.1111/jth.12954

PMCID:: PMC4737230

Abstract Article PDF–726K

Select item 44168598.

Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets

Bhanu Kanth Manne, Rachit Badolia, Carol Dangelmaier, Johannes A. Eble, Wilfried Ellmeier, Mark Kahn, Satya P. Kunapuli

J Biol Chem. 2015 May 1; 290(18): 11557–11568. Published online 2015 Mar 12. doi: 10.1074/jbc.M114.629527

PMCID:: PMC4416859

Abstract Article PDF–1.9M

Select item 43619039.

CLEC-2 activates Syk through dimerisation

Craig E. Hughes, Alice Y. Pollitt, Jun Mori, Johannes A. Eble, Michael G. Tomlinson, John H. Hartwig, Christopher A. O’Callaghan, Klaus Fütterer, Steve P. Watson

Blood. Author manuscript; available in PMC 2015 Mar 17.

Published in final edited form as: Blood. 2010 Apr 8; 115(14): 2947–2955. Published online 2010 Feb 12. doi: 10.1182/blood-2009-08-237834

PMCID:: PMC4361903

Abstract Article PDF–2.1M

Select item 359781210.

Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2)

Bhanu Kanth Manne, Todd M. Getz, Craig E. Hughes, Osama Alshehri, Carol Dangelmaier, Ulhas P. Naik, Steve P. Watson, Satya P. Kunapuli

J Biol Chem. 2013 Mar 15; 288(11): 7717–7726. Published online 2013 Jan 22. doi: 10.1074/jbc.M112.424473

PMCID:: PMC3597812

Abstract Article PDF–1.2M

Select item 357611711.

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)

Craig E. Hughes, Uma Sinha, Anjali Pandey, Johannes A. Eble, Christopher A. O'Callaghan, Steve P. Watson

J Biol Chem. 2013 Feb 15; 288(7): 5127–5135. Published online 2012 Dec 21. doi: 10.1074/jbc.M112.411462

PMCID:: PMC3576117

Abstract Article PDF–1.7M

Select item 338118512.

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

Makoto Osada, Osamu Inoue, Guo Ding, Toshiaki Shirai, Hirotake Ichise, Kazuyoshi Hirayama, Katsuhiro Takano, Yutaka Yatomi, Masanori Hirashima, Hideki Fujii, Katsue Suzuki-Inoue, Yukio Ozaki

J Biol Chem. 2012 Jun 22; 287(26): 22241–22252. Published online 2012 May 3. doi: 10.1074/jbc.M111.329987

PMCID:: PMC3381185

Abstract Article PDF–2.2M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 292244614.

Genome-wide searching of rare genetic variants in WTCCC data

Tao Feng, Xiaofeng Zhu

Hum Genet. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Hum Genet. 2010 Sep; 128(3): 269–280. Published online 2010 Jun 13. doi: 10.1007/s00439-010-0849-9

PMCID:: PMC2922446

Abstract Article PDF–422K

Select item 288530815.

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Chawaree Chaipan, Imke Steffen, Theodros Solomon Tsegaye, Stephanie Bertram, Ilona Glowacka, Yukinari Kato, Jan Schmökel, Jan Münch, Graham Simmons, Rita Gerardy-Schahn, Stefan Pöhlmann

Retrovirology. 2010; 7: 47. Published online 2010 May 19. doi: 10.1186/1742-4690-7-47

PMCID:: PMC2885308

Abstract Article PDF–1.2M

Select item 274933016.

Renal cells activate the platelet receptor CLEC-2 through podoplanin

Charita M. Christou, Andrew C. Pearce, Aleksandra A. Watson, Anita R. Mistry, Alice Y. Pollitt, Angharad E. Fenton-May, Louise A. Johnson, David G. Jackson, Steve P. Watson, Chris A. O'Callaghan

Biochem J. Author manuscript; available in PMC 2009 Sep 23.

Published in final edited form as: Biochem J. 2008 Apr 1; 411(1): 133–140. doi: 10.1042/BJ20071216

PMCID:: PMC2749330

Abstract Article PDF–2.2M

Select item 260289417.

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2

Jun Mori, Andrew C. Pearce, Jennifer C. Spalton, Beata Grygielska, Johannes A. Eble, Michael G. Tomlinson, Yotis A. Senis, Steve P. Watson

J Biol Chem. 2008 Dec 19; 283(51): 35419–35427. doi: 10.1074/jbc.M806895200

PMCID:: PMC2602894

Abstract Article PDF–529K

Select item 252553218.

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2

Aleksandra A. Watson, Johannes A. Eble, Chris A. O'Callaghan

Protein Sci. 2008 Sep; 17(9): 1611–1616. doi: 10.1110/ps.035568.108

PMCID:: PMC2525532

Abstract Article PDF–299K

Select item 197814819.

Crystallization and X-ray diffraction analysis of human CLEC-2

Aleksandra A. Watson, Christopher A. O’Callaghan

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1; 61(Pt 12): 1094–1096. Published online 2005 Nov 24. doi: 10.1107/S1744309105037991

PMCID:: PMC1978148

Abstract Article PDF–225K

Select item 156389620.

DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets

Chawaree Chaipan, Elizabeth J. Soilleux, Peter Simpson, Heike Hofmann, Thomas Gramberg, Andrea Marzi, Martina Geier, Elizabeth A. Stewart, Jutta Eisemann, Alexander Steinkasserer, Katsue Suzuki-Inoue, Gemma L. Fuller, Andrew C. Pearce, Steve P. Watson, James A. Hoxie, Frederic Baribaud, Stefan Pöhlmann

J Virol. 2006 Sep; 80(18): 8951–8960. doi: 10.1128/JVI.00136-06