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Select item 111075571.

BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression

Gema Alcarraz-Vizán, Carlos Castaño, Montse Visa, Joel Montane, Joan-Marc Servitja, Anna Novials

Cell Mol Life Sci. 2017 Aug; 74(15): 2827–2838. Published online 2017 Mar 23. doi: 10.1007/s00018-017-2505-1

PMCID:: PMC11107557

Abstract Article PDF–3.0M

Select item 108553852.

Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity

Stjepan Eržen, Gašper Tonin, Dubravka Jurišić Eržen, Jasna Klen

Int J Mol Sci. 2024 Feb; 25(3): 1517. Published online 2024 Jan 26. doi: 10.3390/ijms25031517

PMCID:: PMC10855385

Abstract Article PDF–2.3M

Select item 107350523.

Impact of Ca²⁺ on Membrane Catalyzed IAPP Amyloid Formation and IAPP Induced Vesicle Leakage

Ming-Hao Li, Xiaoxue Zhang, Erwin London, Daniel P. Raleigh

Biochim Biophys Acta Biomembr. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Biochim Biophys Acta Biomembr. 2023 Aug; 1865(6): 184161. Published online 2023 Apr 28. doi: 10.1016/j.bbamem.2023.184161

PMCID:: PMC10735052

Abstract Article PDF–1002K

Select item 107123004.

Nonhuman IAPP Variants Inhibit Human IAPP Aggregation

Alissa Oakes, Kate Menefee, Arleen Lamba, Larry M. Palato, Dillon J. Rinauro, Angela Tun, Betssy Jauregui, Kevin Chang, Luiza A. Nogaj, David A. Moffet

Protein Pept Lett. Author manuscript; available in PMC 2023 Dec 11.

Published in final edited form as: Protein Pept Lett. 2021; 28(9): 963–971. doi: 10.2174/0929866528666210806152706

PMCID:: PMC10712300

Abstract Article PDF–2.5M

Select item 105317235.

The Aβ42 Peptide and IAPP Physically Interact in a Yeast-Based Assay

Daniel V. Kachkin, Veronika V. Lashkul, Natalia A. Gorsheneva, Sergey A. Fedotov, Maria S. Rubel, Yury O. Chernoff, Aleksandr A. Rubel

Int J Mol Sci. 2023 Sep; 24(18): 14122. Published online 2023 Sep 15. doi: 10.3390/ijms241814122

PMCID:: PMC10531723

Abstract Article PDF–4.0M

Select item 103304436.

Interspecies Variation Affects IAPP Membrane Binding

Henry M. Sanders, Farzaneh Chalyavi, Caitlyn R. Fields, Marius M. Kostelic, Ming-Hao Li, Daniel P. Raleigh, Martin T. Zanni, Michael T. Marty

J Am Soc Mass Spectrom. Author manuscript; available in PMC 2024 Jun 7.

Published in final edited form as: J Am Soc Mass Spectrom. 2023 Jun 7; 34(6): 986–990. Published online 2023 Apr 26. doi: 10.1021/jasms.3c00005

PMCID:: PMC10330443

Abstract Article PDF–806K

Select item 99608377.

Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status

Dovilė Pocevičiūtė, Bodil Roth, Nina Schultz, Cristina Nuñez-Diaz, Shorena Janelidze, The Netherlands Brain Bank , Anders Olofsson, Oskar Hansson, Malin Wennström

Int J Mol Sci. 2023 Feb; 24(4): 3776. Published online 2023 Feb 14. doi: 10.3390/ijms24043776

PMCID:: PMC9960837

Abstract Article PDF–1.3M

Select item 98562098.

Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer’s Disease and Inhibitors of Amyloid Formation

Qing-Rong Liu, Min Zhu, Qinghua Chen, Maja Mustapic, Dimitrios Kapogiannis, Josephine M. Egan

Biomolecules. 2023 Jan; 13(1): 167. Published online 2023 Jan 13. doi: 10.3390/biom13010167

PMCID:: PMC9856209

Abstract Article PDF–3.1M

Select item 94745639.

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

Alexis Z.L. Shih, Yi-Chun Chen, Thilo Speckmann, Esben Søndergaard, Annette Schürmann, C. Bruce Verchere, Thomas E. Willnow

Mol Metab. 2022 Nov; 65: 101585. Published online 2022 Aug 30. doi: 10.1016/j.molmet.2022.101585

PMCID:: PMC9474563

Abstract Article PDF–4.1M

Select item 883840110.

Molecular Mechanisms of Amylin Turnover, Misfolding and Toxicity in the Pancreas

Diti Chatterjee Bhowmick, Zhanar Kudaibergenova, Lydia Burnett, Aleksandar M. Jeremic

Molecules. 2022 Feb; 27(3): 1021. Published online 2022 Feb 2. doi: 10.3390/molecules27031021

PMCID:: PMC8838401

Abstract Article PDF–3.9M

Select item 857985911.

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

Qin Cao, David R. Boyer, Michael R. Sawaya, Peng Ge, David S. Eisenberg

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Nov 10.

Published in final edited form as: Nat Struct Mol Biol. 2020 Jul; 27(7): 653–659. Published online 2020 Jun 15. doi: 10.1038/s41594-020-0435-3

PMCID:: PMC8579859

Abstract Article PDF–5.3M

Select item 849745612.

Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models

Aarti Patel, Ryoichi Kimura, Wen Fu, Rania Soudy, David MacTavish, David Westaway, Jing Yang, Rachel A. Davey, Jeffrey D. Zajac, Jack H. Jhamandas

Mol Neurobiol. 2021; 58(10): 5369–5382. Published online 2021 Jul 27. doi: 10.1007/s12035-021-02490-y

PMCID:: PMC8497456

Abstract Article PDF–9.8M

Select item 837075713.

The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Lior Pytowski, David J. Vaux, Létitia Jean

Biochem J. 2021 Aug 13; 478(15): 3025–3046. Prepublished online 2021 Jul 27. Published online 2021 Aug 13. doi: 10.1042/BCJ20210384

PMCID:: PMC8370757

Abstract Article PDF–47M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 800170115.

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson

Biomolecules. 2021 Mar; 11(3): 411. Published online 2021 Mar 10. doi: 10.3390/biom11030411

PMCID:: PMC8001701

Abstract Article PDF–1.9M

Select item 786459016.

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

Yi-Chun Chen, Richard E. Mains, Betty A. Eipper, Brad G. Hoffman, Traci A. Czyzyk, John E. Pintar, C. Bruce Verchere

Diabetologia. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: Diabetologia. 2020 Mar; 63(3): 561–576. Published online 2020 Jan 27. doi: 10.1007/s00125-019-05060-z

Correction in:: Diabetologia. 2020 Mar 14

PMCID:: PMC7864590

Abstract Article PDF–2.6M

Select item 779441917.

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Jinyoung Kim, Kihyoun Park, Min Jung Kim, Hyejin Lim, Kook Hwan Kim, Sun-Woo Kim, Eun-Seo Lee, Hyongbum (Henry) Kim, Sung Joo Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jin Hee Ahn, Kun-Ho Yoon, Ji-Won Kim, Myung-Shik Lee

Nat Commun. 2021; 12: 183. Published online 2021 Jan 8. doi: 10.1038/s41467-020-20454-z

PMCID:: PMC7794419

Abstract Article PDF–6.7M

Select item 770201918.

Analysis of Amylin Consensus Sequences Suggests that Human Amylin is Not Optimized to Minimize Amyloid Formation and Provides Clues to Factors that Modulate Amyloidogenicity

Daeun Noh, Rebekah L Bower, Debbie L Hay, Alexander Zhyvoloup, Daniel P Raleigh

ACS Chem Biol. Author manuscript; available in PMC 2021 Jun 19.

Published in final edited form as: ACS Chem Biol. 2020 Jun 19; 15(6): 1408–1416. Published online 2020 Jun 3. doi: 10.1021/acschembio.9b01050

PMCID:: PMC7702019

Abstract Article PDF–1.4M

Select item 768632219.

α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

Marija Mucibabic, Pär Steneberg, Emmelie Lidh, Jurate Straseviciene, Agnieszka Ziolkowska, Ulf Dahl, Emma Lindahl, Helena Edlund

Sci Rep. 2020; 10: 20438. Published online 2020 Nov 24. doi: 10.1038/s41598-020-77409-z

PMCID:: PMC7686322

Abstract Article PDF–4.7M

Select item 752858220.

Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic

Andrew N. Bubak, Cheryl Beseler, Christina N. Como, Stephen K. Tyring, Christopher Haley, Teresa Mescher, James E. Hassell, Jr., Randall J. Cohrs, Huntington Potter, Maria A. Nagel

J Neurovirol. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: J Neurovirol. 2020 Jun; 26(3): 422–428. Published online 2020 May 8. doi: 10.1007/s13365-020-00830-7

PMCID:: PMC7528582

Abstract Article PDF–448K

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