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Select item 111658891.

Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz

Mol Neurodegener. 2024; 19: 46. Published online 2024 Jun 11. doi: 10.1186/s13024-024-00737-5

PMCID:: PMC11165889

Abstract Article PDF–2.8M

Select item 111627722.

FUS reads histone H3K36me3 to regulate alternative polyadenylation

Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang

Nucleic Acids Res. 2024 Jun 10; 52(10): 5549–5571. Published online 2024 Mar 18. doi: 10.1093/nar/gkae184

PMCID:: PMC11162772

Abstract Article PDF–2.7M

Select item 111590433.

Pigpen, a nuclear coiled body component protein, is involved in angiogenesis

Tomoko Yoshida, Yasufumi Sato, Ikuo Morita, Mayumi Abe

Cancer Sci. 2010 May; 101(5): 1170–1176. Published online 2010 Jan 12. doi: 10.1111/j.1349-7006.2010.01494.x

PMCID:: PMC11159043

Abstract Article PDF–924K

Select item 111409664.

The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice

Chenyi Zhong, Huiyuan Wang, Xiong Yuan, Yuheng He, Jing Cong, Rui Yang, Wenjie Ma, Li Gao, Chao Gao, Yugui Cui, Jie Wu, Rongrong Tan, Danhua Pu

Biol Res. 2024; 57: 36. Published online 2024 May 31. doi: 10.1186/s40659-024-00518-w

PMCID:: PMC11140966

Abstract Article PDF–7.5M

Select item 109400945.

Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice

Manuel Chiusa, Youngmin A. Lee, Ming-Zhi Zhang, Raymond C. Harris, Taylor Sherrill, Volkhard Lindner, Craig R. Brooks, Gang Yu, Agnes B. Fogo, Charles R. Flynn, Jozef Zienkiewicz, Jacek Hawiger, Roy Zent, Ambra Pozzi

J Clin Invest. 2024 Mar 15; 134(6): e175158. Published online 2024 Mar 15. doi: 10.1172/JCI175158

PMCID:: PMC10940094

Abstract Article PDF–29M

Select item 109250636.

FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease

Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Vincent Provasek, Vikas H. Maloji Rao, Indira Vedula, Aijun Zhang, Sankar Mitra, Alan E. Tomkinson, Dale J. Hamilton, Ludo Van Den Bosch, Muralidhar L. Hegde

Nat Commun. 2024; 15: 2156. Published online 2024 Mar 9. doi: 10.1038/s41467-024-45978-6

PMCID:: PMC10925063

Abstract Article PDF–3.1M

Select item 109176607.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106426118.

Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations

Zeinab Ali, Juan M. Godoy-Corchuelo, Aurea B. Martins-Bach, Irene Garcia-Toledo, Luis C. Fernández-Beltrán, Remya R. Nair, Shoshana Spring, Brian J. Nieman, Irene Jimenez-Coca, Rasneer S. Bains, Hamish Forrest, Jason P. Lerch, Karla L. Miller, Elizabeth M. C. Fisher, Thomas J. Cunningham, Silvia Corrochano

Dis Model Mech. 2023 Oct 1; 16(10): dmm050200. Published online 2023 Oct 23. doi: 10.1242/dmm.050200

PMCID:: PMC10642611

Abstract Article

Select item 106187099.

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling

iScience. 2023 Nov 17; 26(11): 108152. Published online 2023 Oct 6. doi: 10.1016/j.isci.2023.108152

PMCID:: PMC10618709

Abstract Article PDF–6.0M

Select item 1033459910.

CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability

Mingsi Deng, Zhengguang Wang, Jia Luo, Heng Cao, Yong Li, Liangjian Chen, Gengyan Liu

J Orthop Surg Res. 2023; 18: 492. Published online 2023 Jul 11. doi: 10.1186/s13018-023-03955-7

PMCID:: PMC10334599

Abstract Article PDF–9.2M

Select item 1008962311.

Clonally expanded CD8 T cells characterize Amyotrophic Lateral Sclerosis 4

Laura Campisi, Shahab Chizari, Jessica S.Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-forn, Miguel Jiménez Alcázar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia de Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi

Nature. Author manuscript; available in PMC 2023 Apr 11.

Published in final edited form as: Nature. 2022 Jun; 606(7916): 945–952. Published online 2022 Jun 22. doi: 10.1038/s41586-022-04844-5

Correction in:: Nature. 2022 Aug; 608(7924): E34.

PMCID:: PMC10089623

Abstract Article PDF–7.6M

Select item 1004039912.

The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots

Teresa Giannattasio, Erika Testa, Ramona Palombo, Lidia Chellini, Flavia Franceschini, Álvaro Crevenna, Petko M. Petkov, Maria Paola Paronetto, Marco Barchi

Cell Mol Life Sci. 2023 Apr; 80(4): 107. Published online 2023 Mar 26. doi: 10.1007/s00018-023-04744-5

PMCID:: PMC10040399

Abstract Article PDF–2.0M

Select item 960386013.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 879946414.

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

Vladislav A. Korobeynikov, Alexander K. Lyashchenko, Beatriz Blanco-Redondo, Paymaan Jafar-Nejad, Neil A. Shneider

Nat Med. 2022; 28(1): 104–116. Published online 2022 Jan 24. doi: 10.1038/s41591-021-01615-z

PMCID:: PMC8799464

Abstract Article PDF–8.7M

Select item 874425715.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 873932516.

FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development

Teresa Chioccarelli, Geppino Falco, Donato Cappetta, Antonella De Angelis, Luca Roberto, Martina Addeo, Marco Ragusa, Davide Barbagallo, Liberato Berrino, Michele Purrello, Concetta Ambrosino, Gilda Cobellis, Riccardo Pierantoni, Rosanna Chianese, Francesco Manfrevola

Cell Mol Life Sci. 2022 Jan; 79(1): 50. Published online 2021 Dec 22. doi: 10.1007/s00018-021-04054-8

PMCID:: PMC8739325

Abstract Article PDF–2.5M

Select item 871055717.

Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair Allan, Gemma F. Codner, Remya R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero-Gagliardi, José M. Brito-Armas, Chloe Williams, Muhammet M. Öztürk, Michelle Simon, Edward O'Neill, Sam Bryce-Smith, Jackie Harrison, Gemma Atkins, Silvia Corrochano, Michelle Stewart, Jonathan D. Gilthorpe, Lydia Teboul, Abraham Acevedo-Arozena, Elizabeth M.C. Fisher, Thomas J. Cunningham

iScience. 2021 Dec 17; 24(12): 103463. Published online 2021 Nov 15. doi: 10.1016/j.isci.2021.103463

Correction in:: iScience. 2022 Apr 15; 25(4): 103999.

PMCID:: PMC8710557

Abstract Article PDF–6.0M

Select item 848038518.

circ-Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS

Shijing Sun, Qingyu Kong, Zhifeng Cai, Minmin Wang, Haizhao Zhao, Cuifen Zhao

Int J Mol Med. 2021 Nov; 48(5): 202. Published online 2021 Sep 16. doi: 10.3892/ijmm.2021.5035

PMCID:: PMC8480385

Abstract Article PDF–8.7M

Select item 841995619.

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis

Mol Neurodegener. 2021; 16: 61. Published online 2021 Sep 6. doi: 10.1186/s13024-021-00477-w

PMCID:: PMC8419956

Abstract Article PDF–4.0M

Select item 841076720.

Maria Giovanna Garone, Nicol Birsa, Maria Rosito, Federico Salaris, Michela Mochi, Valeria de Turris, Remya R. Nair, Thomas J. Cunningham, Elizabeth M. C. Fisher, Mariangela Morlando, Pietro Fratta, Alessandro Rosa

Commun Biol. 2021; 4: 1025. Published online 2021 Sep 1. doi: 10.1038/s42003-021-02538-8

PMCID:: PMC8410767

Abstract Article PDF–4.9M

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