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Items: 1 to 20 of 51

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The N-degron pathway mediates lipophagy: the chemical modulation of lipophagy in obesity and NAFLD
Eui Jung Jung, Ki Woon Sung, Tae Hyun Bae, Hee-Yeon Kim, Ha Rim Choi, Sung Hyun Kim, Chan Hoon Jung, Su Ran Mun, Yeon Sung Son, Shin Kim, Young Ho Suh, Anna Kashina, Joo-Won Park, Yong Tae Kwon
Metabolism. Author manuscript; available in PMC 2024 Sep 1.
Published in final edited form as: Metabolism. 2023 Sep; 146: 155644. Published online 2023 Jun 28. doi: 10.1016/j.metabol.2023.155644
PMCID:
PMC10529862
AbstractArticlePDF–5.5M
3.
The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10
Sang Mi Shim, Ha Rim Choi, Soon Chul Kwon, Hye Yeon Kim, Ki Woon Sung, Eui Jung Jung, Su Ran Mun, Tae Hyun Bae, Dong Hyun Kim, Yeon Sung Son, Chan Hoon Jung, Jihoon Lee, Min Jae Lee, Joo-Won Park, Yong Tae Kwon
Autophagy. 2023; 19(6): 1642–1661. Published online 2022 Oct 2. doi: 10.1080/15548627.2022.2126617
PMCID:
PMC10262816
AbstractArticlePDF–6.3M
4.
The N-terminal cysteine is a dual sensor of oxygen and oxidative stress
Ah Jung Heo, Su Bin Kim, Chang Hoon Ji, Dohyun Han, Su Jin Lee, Su Hyun Lee, Min Ju Lee, Ji Su Lee, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon
Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2107993118. Published online 2021 Dec 10. doi: 10.1073/pnas.2107993118
PMCID:
PMC8685671
AbstractArticlePDF–3.1M
5.
Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses
Marie E. Fina, Junling Wang, Sergei S. Nikonov, Stephanie Sterling, Noga Vardi, Anna Kashina, Dawei W. Dong
Sci Rep. 2021; 11: 9376. Published online 2021 Apr 30. doi: 10.1038/s41598-021-88628-3
PMCID:
PMC8087773
AbstractArticlePDF–4.1M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis
Verna Van, Aaron T. Smith
ACS Chem Biol. Author manuscript; available in PMC 2021 Dec 18.
Published in final edited form as: ACS Chem Biol. 2020 Dec 18; 15(12): 3073–3085. Published online 2020 Nov 23. doi: 10.1021/acschembio.0c00677
PMCID:
PMC7749041
AbstractArticlePDF–1.2M
8.
The final maturation state of β-actin involves N-terminal acetylation by NAA80, not N-terminal arginylation by ATE1
Adrian Drazic, Evy Timmerman, Ulrike Kajan, Michaёl Marie, Sylvia Varland, Francis Impens, Kris Gevaert, Thomas Arnesen
J Mol Biol. Author manuscript; available in PMC 2022 Dec 14.
Published in final edited form as: J Mol Biol. 2022 Jan 30; 434(2): 167397. Published online 2021 Dec 9. doi: 10.1016/j.jmb.2021.167397
PMCID:
PMC7613935
AbstractArticlePDF–1.7M
9.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
10.
Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis
Michael D. Birnbaum, Ning Zhao, Balaji T. Moorthy, Devang M. Patel, Oleksandr N. Kryvenko, Laine Heidman, Akhilesh Kumar, William M. Morgan, Yuguang Ban, Isildinha M. Reis, Xi Chen, Mark L. Gonzalgo, Merce Jorda, Kerry L. Burnstein, Fangliang Zhang
Oncogene. Author manuscript; available in PMC 2019 Mar 3.
Published in final edited form as: Oncogene. 2019 Feb; 38(6): 838–851. Published online 2018 Sep 3. doi: 10.1038/s41388-018-0462-2
PMCID:
PMC6368462
AbstractArticlePDF–1.0M
11.
Target site specificity and in vivo complexity of the mammalian arginylome
Junling Wang, Vikas Rao Pejaver, Geoffrey P. Dann, Max Y. Wolf, Manolis Kellis, Yun Huang, Benjamin A. Garcia, Predrag Radivojac, Anna Kashina
Sci Rep. 2018; 8: 16177. Published online 2018 Nov 1. doi: 10.1038/s41598-018-34639-6
PMCID:
PMC6212499
AbstractArticlePDF–2.5M
12.
N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis
Young Dong Yoo, Su Ran Mun, Chang Hoon Ji, Ki Woon Sung, Keum Young Kang, Ah Jung Heo, Su Hyun Lee, Jee Young An, Joonsung Hwang, Xiang-Qun Xie, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon
Proc Natl Acad Sci U S A. 2018 Mar 20; 115(12): E2716–E2724. Published online 2018 Mar 5. doi: 10.1073/pnas.1719110115
PMCID:
PMC5866579
AbstractArticlePDF–2.2M
13.
Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development
Junling Wang, Iuliia Pavlyk, Pavan Vedula, Stephanie Sterling, N. Adrian Leu, Dawei W. Dong, Anna Kashina
Dev Biol. Author manuscript; available in PMC 2017 Oct 5.
Published in final edited form as: Dev Biol. 2017 Oct 1; 430(1): 41–51. Published online 2017 Aug 26. doi: 10.1016/j.ydbio.2017.08.027
PMCID:
PMC5628761
AbstractArticlePDF–1.9M
14.
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration
Junling Wang, Xuemei Han, Nicolae Adrian Leu, Stephanie Sterling, Satoshi Kurosaka, Marie Fina, Virginia M. Lee, Dawei W. Dong, John R. Yates, III, Anna Kashina
Sci Rep. 2017; 7: 11323. Published online 2017 Sep 12. doi: 10.1038/s41598-017-11713-z
PMCID:
PMC5595787
AbstractArticlePDF–6.2M
15.
The Placental Interleukin-6 Signaling Controls Fetal Brain Development and Behavior
Wei-Li Wu, Elaine Y. Hsiao, Zihao Yan, Sarkis K. Mazmanian, Paul H. Patterson
Brain Behav Immun. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Brain Behav Immun. 2017 May; 62: 11–23. Published online 2016 Nov 9. doi: 10.1016/j.bbi.2016.11.007
PMCID:
PMC5373986
AbstractArticlePDF–1.5M
16.
Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays
Brandon Wadas, Konstantin I. Piatkov, Christopher S. Brower, Alexander Varshavsky
J Biol Chem. 2016 Sep 30; 291(40): 20976–20992. Published online 2016 Aug 10. doi: 10.1074/jbc.M116.747956
PMCID:
PMC5076509
AbstractArticlePDF–2.6M
17.
Ablation of Arg-tRNA-protein transferases results in defective neural tube development
Eunkyoung Kim, Seonmu Kim, Jung Hoon Lee, Yong Tae Kwon, Min Jae Lee
BMB Rep. 2016 Aug 31; 49(8): 443–448. doi: 10.5483/BMBRep.2016.49.8.087
PMCID:
PMC5070732
AbstractArticlePDF–11M
18.
Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response
Akhilesh Kumar, Michael D Birnbaum, Devang M Patel, William M Morgan, Jayanti Singh, Antoni Barrientos, Fangliang Zhang
Cell Death Dis. 2016 Sep; 7(9): e2378. Published online 2016 Sep 29. doi: 10.1038/cddis.2016.284
PMCID:
PMC5059882
AbstractArticlePDF–2.6M
19.
Arginyltransferase ATE1 suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers
Reena Rai, Fangliang Zhang, Kristen Colavita, Nicolae Adrian Leu, Satoshi Kurosaka, Akhilesh Kumar, Michael D. Birnbaum, Balázs Gyorffy, Dawei W. Dong, Michael Shtutman, Anna Kashina
Oncogene. Author manuscript; available in PMC 2016 Aug 10.
Published in final edited form as: Oncogene. 2016 Aug 4; 35(31): 4058–4068. Published online 2015 Dec 21. doi: 10.1038/onc.2015.473
PMCID:
PMC4916053
AbstractArticlePDF–2.4M
20.
Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway
Yu-Jiao Liu, Chao Liu, ZeNan Chang, Brandon Wadas, Christopher S. Brower, Zhen-Hua Song, Zhi-Liang Xu, Yong-Liang Shang, Wei-Xiao Liu, Li-Na Wang, Wen Dong, Alexander Varshavsky, Rong-Gui Hu, Wei Li
J Biol Chem. 2016 Apr 1; 291(14): 7426–7438. Published online 2016 Feb 8. doi: 10.1074/jbc.M116.714964
PMCID:
PMC4817174
AbstractArticlePDF–2.4M

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