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Items: 1 to 20 of 77

1.
Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality
Megan A. Mendenhall, Shihui Liu, Makayla K. Portley, Danielle O’Mard, Rasem Fattah, Roman Szabo, Thomas H. Bugge, Jaspal S. Khillan, Stephen H. Leppla, Mahtab Moayeri
Nat Microbiol. Author manuscript; available in PMC 2024 Nov 6.
Published in final edited form as: Nat Microbiol. 2020 Dec; 5(12): 1464–1471. Published online 2020 Sep 7. doi: 10.1038/s41564-020-0782-1
PMCID:
PMC11540063
AbstractArticlePDF–2.1M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development
Xiangyan Wang, Yan Zhang, Jianjie Yu, Yabo Ma, Yaxiu Xu, Jiaqi Shi, Zhipeng Qi, Xinfeng Liu
BMC Genomics. 2024; 25: 139. Published online 2024 Feb 3. doi: 10.1186/s12864-024-10058-y
PMCID:
PMC10837906
AbstractArticlePDF–7.1M
4.
Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK
Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathon I. Wilde, Kadalmani Krishnan, Murray J.B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen
J Biol Chem. 2022 Jun; 298(6): 101916. Published online 2022 Apr 13. doi: 10.1016/j.jbc.2022.101916
PMCID:
PMC9127371
AbstractArticlePDF–2.6M
5.
Expression of gilt acts as a Positive Regulator of Mouse Hematopoietic Progenitor Cells
Hal E. Broxmeyer, Scott Cooper, Janice S. Blum
Blood Cells Mol Dis. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Blood Cells Mol Dis. 2021 Sep; 90: 102574. Published online 2021 Apr 30. doi: 10.1016/j.bcmd.2021.102574
PMCID:
PMC8338767
AbstractArticlePDF–480K
6.
Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling
Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang
Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068
PMCID:
PMC8245041
AbstractArticlePDF–1.8M
7.
PIK3R2/Pik3r2 activating mutations result in brain overgrowth and EEG changes
Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa, Tao Tao, Jeffrey A. Golden
Ann Neurol. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Ann Neurol. 2020 Dec; 88(6): 1077–1094. Published online 2020 Sep 28. doi: 10.1002/ana.25890
PMCID:
PMC8176885
AbstractArticlePDF–1.8M
8.
A non-immunological role for γ-interferon–inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption
Benjamin W. Ewanchuk, Corey R. Arnold, Dale R. Balce, Priyatha Premnath, Tanis L. Orsetti, Amy L. Warren, Alexandra Olsen, Roman J. Krawetz, Robin M. Yates
Sci Adv. 2021 Apr; 7(17): eabd3684. Published online 2021 Apr 23. doi: 10.1126/sciadv.abd3684
PMCID:
PMC8064644
AbstractArticlePDF–46M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
GILT in thymic epithelial cells facilitates central CD4 T cell tolerance to a tissue-restricted, melanoma-associated self antigen
Matthew P. Rausch, Lydia R. Meador, Todd C. Metzger, Handong Li, Shenfeng Qiu, Mark S. Anderson, K. Taraszka Hastings
J Immunol. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: J Immunol. 2020 Jun 1; 204(11): 2877–2886. Published online 2020 Apr 8. doi: 10.4049/jimmunol.1900523
PMCID:
PMC7336541
AbstractArticlePDF–957K
11.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
12.
Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each
Afzal M. Dogar, Ramona Pauchard-Batschulat, Barbara Grisoni-Neupert, Larry Richman, Alexandra Paillusson, Sylvain Pradervand, Otto Hagenbüchle, Giovanna Ambrosini, Christoph D. Schmid, Philipp Bucher, Lukas C. Kühn
PLoS One. 2018; 13(11): e0206823. Published online 2018 Nov 12. doi: 10.1371/journal.pone.0206823
PMCID:
PMC6231638
AbstractArticlePDF–3.8M
13.
The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization
Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber
Oncogene. Author manuscript; available in PMC 2017 Feb 14.
Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331
PMCID:
PMC5308218
AbstractArticlePDF–3.8M
14.
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor
Grinu Mathew, Abdul Hannan, Kristina Hertzler-Schaefer, Fen Wang, Gen-Sheng Feng, Jian Zhong, Jean J. Zhao, Julian Downward, Xin Zhang
Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46): 13156–13161. Published online 2016 Oct 31. doi: 10.1073/pnas.1604450113
PMCID:
PMC5135310
AbstractArticlePDF–2.1M
15.
Reduced immunogenicity of Plasmodium falciparum gamete surface antigen (Pfs48/45) in mice after disruption of disulphide bonds – evaluating effect of interferon‐γ‐inducible lysosomal thiol reductase
Kristen M. Merino, Geetha P. Bansal, Nirbhay Kumar
Immunology. 2016 Aug; 148(4): 433–447. Published online 2016 Jun 29. doi: 10.1111/imm.12621
PMCID:
PMC4948042
AbstractArticlePDF–599K
16.
Endogenous antigen processing drives the primary CD4+ T cell response to influenza
Michael A. Miller, Asha Purnima V. Ganesan, Nancy Luckashenak, Mark Mendonca, Laurence C. Eisenlohr
Nat Med. Author manuscript; available in PMC 2016 Apr 1.
Published in final edited form as: Nat Med. 2015 Oct; 21(10): 1216–1222. Published online 2015 Sep 28. doi: 10.1038/nm.3958
PMCID:
PMC4629989
AbstractArticlePDF–998K
17.
An Exhaustion-Like Phenotype Constrains the Activity of CD4+ T Cells Specific for a Self and Melanoma Antigen
Matthew P. Rausch, Karen Taraszka Hastings
PLoS One. 2015; 10(4): e0123332. Published online 2015 Apr 15. doi: 10.1371/journal.pone.0123332
PMCID:
PMC4398374
AbstractArticlePDF–571K
18.
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Thati Madhusudhan, Hongjie Wang, Wei Dong, Sanchita Ghosh, Fabian Bock, Veera Raghavan Thangapandi, Satish Ranjan, Juliane Wolter, Shrey Kohli, Khurrum Shahzad, Florian Heidel, Martin Krueger, Vedat Schwenger, Marcus J. Moeller, Thomas Kalinski, Jochen Reiser, Triantafyllos Chavakis, Berend Isermann
Nat Commun. 2015 Mar 10; 6: 6496. Published online 2015 Mar 10. doi: 10.1038/ncomms7496
PMCID:
PMC4366504
AbstractArticlePDF–5.2M
19.
γ-Interferon-inducible Lysosomal Thiol Reductase (GILT) Maintains Phagosomal Proteolysis in Alternatively Activated Macrophages
Dale R. Balce, Euan R. O. Allan, Neil McKenna, Robin M. Yates
J Biol Chem. 2014 Nov 14; 289(46): 31891–31904. Published online 2014 Sep 24. doi: 10.1074/jbc.M114.584391
PMCID:
PMC4231668
AbstractArticlePDF–2.0M
20.
Phosphoinositide 3-kinase p85beta regulates invadopodium formation
Ariel E. Cariaga-Martínez, Isabel Cortés, Esther García, Vicente Pérez-García, María J. Pajares, Miguel A. Idoate, Javier Redondo-Muñóz, Inés M. Antón, Ana C. Carrera
Biol Open. 2014 Oct 15; 3(10): 924–936. Published online 2014 Sep 12. doi: 10.1242/bio.20148185
PMCID:
PMC4197441
AbstractArticlePDF–2.0M

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