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Select item 113333791.

Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging

Jose A. Ortiz, Nadiah Ghazalli, Kassandra Lopez, Jeffrey Rawson, Erika M. McCown, Eunjin Oh, Jose M. Irimia, Kevin Jou, Jacob Mares, Min-Hsuan Chen, Xiwei Wu, Heather N. Zook, Janine C. Quijano, Neslihan Erdem, Anahy Lizarraga, Fouad Kandeel, Patrick T. Fueger, Debbie C. Thurmond, Hsun Teresa Ku

Diabetes. 2024 Sep; 73(9): 1447–1461. Published online 2024 Jun 21. doi: 10.2337/db23-0490

PMCID:: PMC11333379

Abstract Article PDF–209M

Select item 110193442.

Loss of SUR1 subtype K_ATP channels alters antinociception and locomotor activity after opioid administration

Gerald Sakamaki, Kayla Johnson, Megan Mensinger, Eindray Hmu, Amanda H. Klein

Behav Brain Res. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Behav Brain Res. 2021 Sep 24; 414: 113467. Published online 2021 Jul 15. doi: 10.1016/j.bbr.2021.113467

PMCID:: PMC11019344

Abstract Article PDF–1.1M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105707134.

Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

Anna B. Osipovich, Frank Y. Zhou, Judy J. Chong, Linh T. Trinh, Mathew A. Cottam, Shristi Shrestha, Jean-Philippe Cartailler, Mark A. Magnuson

Mol Metab. 2023 Dec; 78: 101811. Published online 2023 Sep 26. doi: 10.1016/j.molmet.2023.101811

PMCID:: PMC10570713

Abstract Article PDF–3.8M

Select item 104508255.

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato

Diabetes. 2023 Sep; 72(9): 1320–1329. Published online 2023 Jun 26. doi: 10.2337/db22-1039

PMCID:: PMC10450825

Abstract Article PDF–27M

Select item 98629646.

Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis

Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja

J Neuroinflammation. 2023; 20: 12. Published online 2023 Jan 21. doi: 10.1186/s12974-023-02692-2

PMCID:: PMC9862964

Abstract Article PDF–3.0M

Select item 91243037.

Role of upregulation of the K_ATP channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson’s disease

Min Liu, Cui Liu, Xue Xiao, Shuai‐Shuai Han, Ming‐Xia Bi, Qian Jiao, Xi Chen, Chun‐Ling Yan, Xi‐Xun Du, Hong Jiang

Aging Cell. 2022 May; 21(5): e13618. Published online 2022 Apr 20. doi: 10.1111/acel.13618

PMCID:: PMC9124303

Abstract Article PDF–3.0M

Select item 85891608.

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

Erika Gurzeler, Anna-Kaisa Ruotsalainen, Anssi Laine, Teemu Valkama, Sanna Kettunen, Markku Laakso, Seppo Ylä-Herttuala

PLoS One. 2021; 16(11): e0258408. Published online 2021 Nov 12. doi: 10.1371/journal.pone.0258408

PMCID:: PMC8589160

Abstract Article PDF–2.9M

Select item 84031869.

Abcc8 (Sulfonylurea Receptor-1) Impact on Brain Atrophy after Traumatic Brain Injury Varies by Sex

Swathi Tata, Benjamin E. Zusman, Patrick M. Kochanek, Volodymyr Gerzanich, Min Seong Kwon, Seung Kyoon Woo, Robert S.B. Clark, Keri Janesko-Feldman, Vincent A. Vagni, J. Marc Simard, Ruchira M. Jha

J Neurotrauma. September 1, 2021; 38(17): 2473–2485. Published online 2021 Aug 13. doi: 10.1089/neu.2021.0105

PMCID:: PMC8403186

Abstract Article PDF–728K

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 802110611.

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols

JCI Insight. 2021 Mar 8; 6(5): e145934. Published online 2021 Mar 8. doi: 10.1172/jci.insight.145934

PMCID:: PMC8021106

Abstract Article PDF–1.4M

Select item 780971512.

Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells

Anna B. Osipovich, Jennifer S. Stancill, Jean-Philippe Cartailler, Karrie D. Dudek, Mark A. Magnuson

Diabetes. 2020 Jul; 69(7): 1476–1491. Published online 2020 Apr 24. doi: 10.2337/db19-1145

PMCID:: PMC7809715

Abstract Article PDF–2.2M

Select item 739444213.

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1^-/- mouse model

Mangala M. Soundarapandian, Christine A. Juliana, Jinghua Chai, Patrick A. Haslett, Kevin Fitzgerald, Diva D. De León

PLoS One. 2020; 15(7): e0236892. Published online 2020 Jul 31. doi: 10.1371/journal.pone.0236892

PMCID:: PMC7394442

Abstract Article PDF–2.0M

Select item 681747114.

Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype K_ATP Channel Activity in Mice

Cole Fisher, Kayla Johnson, Travis Okerman, Taylor Jurgenson, Austin Nickell, Erin Salo, Madelyn Moore, Alexis Doucette, James Bjork, Amanda H. Klein

Front Neurosci. 2019; 13: 1122. Published online 2019 Oct 22. doi: 10.3389/fnins.2019.01122

PMCID:: PMC6817471

Abstract Article PDF–2.8M

Select item 653973515.

Modulation of SUR1 K_ATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice

Wing Luu, James Bjork, Erin Salo, Nicole Entenmann, Taylor Jurgenson, Cole Fisher, Amanda H. Klein

Int J Mol Sci. 2019 May; 20(9): 2251. Published online 2019 May 7. doi: 10.3390/ijms20092251

PMCID:: PMC6539735

Abstract Article PDF–3.3M

Select item 575905316.

SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

Jesse A. Stokum, Min S. Kwon, Seung K. Woo, Orest Tsymbalyuk, Rudi Vennekens, Volodymyr Gerzanich, J. Marc Simard

Glia. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Glia. 2018 Jan; 66(1): 108–125. Published online 2017 Sep 14. doi: 10.1002/glia.23231

PMCID:: PMC5759053

Abstract Article PDF–2.5M

Select item 553686517.

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, James M. Wells

Development. 2017 Jul 1; 144(13): 2402–2414. doi: 10.1242/dev.146316

PMCID:: PMC5536865

Abstract Article

Select item 552187018.

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca²⁺-Regulated Genes

Jennifer S. Stancill, Jean-Philippe Cartailler, Hannah W. Clayton, James T. O’Connor, Matthew T. Dickerson, Prasanna K. Dadi, Anna B. Osipovich, David A. Jacobson, Mark A. Magnuson

Diabetes. 2017 Aug; 66(8): 2175–2187. Published online 2017 May 26. doi: 10.2337/db16-1355

PMCID:: PMC5521870

Abstract Article PDF–2.8M

Select item 540707619.

Glucose elicits cephalic-phase insulin release in mice by activating K_ATP channels in taste cells

John I. Glendinning, Yonina G. Frim, Ayelet Hochman, Gabrielle S. Lubitz, Anthony J. Basile, Anthony Sclafani

Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1; 312(4): R597–R610. Published online 2017 Jan 27. doi: 10.1152/ajpregu.00433.2016

PMCID:: PMC5407076

Abstract Article

Select item 499905820.

SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury

James D. Nicholson, Yan Guo, Steven L. Bernstein

PLoS One. 2016; 11(8): e0148855. Published online 2016 Aug 25. doi: 10.1371/journal.pone.0148855

PMCID:: PMC4999058

Abstract Article PDF–1.6M

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