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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104337292.

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Mena Abdel-Nour, Leticia A. M. Carneiro, Jeffrey Downey, Jessica Tsalikis, Ahmed Outlioua, Dave Prescott, Leandro Silva Da Costa, Elise S. Hovingh, Armin Farahvash, Ryan G. Gaudet, Raphael Molinaro, Rob van Dalen, Charles C. Y. Lau, Farshad C. Azimi, Nichole K. Escalante, Aaron Trotman-Grant, Jeffrey E. Lee, Scott D. Gray-Owen, Maziar Divangahi, Jane-Jane Chen, Dana J. Philpott, Damien Arnoult, Stephen E. Girardin

Science. Author manuscript; available in PMC 2023 Aug 17.

Published in final edited form as: Science. 2019 Jul 5; 365(6448): eaaw4144. doi: 10.1126/science.aaw4144

PMCID:: PMC10433729

Abstract Article PDF–2.2M

Select item 95234913.

Mitochondrial stress induces an HRI-eIF2α pathway protective for cardiomyopathy

Siting Zhu, Anh Nguyen, Jing Pang, Jun Zhao, Ze’e Chen, Zhengyu Liang, Yusu Gu, Helen Huynh, Yutong Bao, Sharon Lee, Yuval Kluger, Kunfu Ouyang, Sylvia M Evans, Xi Fang

Circulation. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Circulation. 2022 Sep 27; 146(13): 1028–1031. Published online 2022 Sep 26. doi: 10.1161/CIRCULATIONAHA.122.059594

PMCID:: PMC9523491

Article PDF–1016K

Select item 80168974.

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase

Eva Ramos-Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela-Nallar, Nibaldo C. Inestrosa

Sci Rep. 2021; 11: 7395. Published online 2021 Apr 1. doi: 10.1038/s41598-021-86708-y

PMCID:: PMC8016897

Abstract Article PDF–6.1M

Select item 79489855.

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Tapas Mukherjee, Valeria Ramaglia, Mena Abdel-Nour, Athanasia A. Bianchi, Jessica Tsalikis, Hien N. Chau, Suneil K. Kalia, Lorraine V. Kalia, Jane-Jane Chen, Damien Arnoult, Jennifer L. Gommerman, Dana J. Philpott, Stephen E. Girardin

J Biol Chem. 2021 Jan-Jun; 296: 100050. Published online 2020 Dec 2. doi: 10.1074/jbc.RA120.014415

PMCID:: PMC7948985

Abstract Article PDF–2.9M

Select item 72900976.

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood. 2020 Jun 11; 135(24): 2121–2132. Prepublished online 2020 Apr 16. doi: 10.1182/blood.2020005301

PMCID:: PMC7290097

Abstract Article

Select item 72246987.

The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

Beatriz Alvarez-Castelao, Susanne tom Dieck, Claudia M Fusco, Paul Donlin-Asp, Julio D Perez, Erin M Schuman

eLife. 2020; 9: e52714. Published online 2020 Apr 24. doi: 10.7554/eLife.52714

PMCID:: PMC7224698

Abstract Article PDF–2.8M

Select item 70642018.

Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

Yoshimasa Hamada, Yuji Furumoto, Akira Izutani, Shusuke Taniuchi, Masato Miyake, Miho Oyadomari, Kenji Teranishi, Naoyuki Shimomura, Seiichi Oyadomari

PLoS One. 2020; 15(3): e0229948. Published online 2020 Mar 10. doi: 10.1371/journal.pone.0229948

PMCID:: PMC7064201

Abstract Article PDF–1.6M

Select item 68569859.

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang

Blood. 2019 Nov 14; 134(20): 1697–1707. Prepublished online 2019 Sep 25. doi: 10.1182/blood.2019001915

PMCID:: PMC6856985

Abstract Article

Select item 605142010.

ATF4 Regulates CD4⁺ T Cell Immune Responses through Metabolic Reprogramming

Xi Yang, Rui Xia, Cuihua Yue, Wensi Zhai, Wenwen Du, Qianting Yang, Huiling Cao, Xiaojuan Chen, Danielle Obando, Yibei Zhu, Xinchun Chen, Jane-Jane Chen, Jon Piganelli, Peter Wipf, Yu Jiang, Guozhi Xiao, Changping Wu, Jingting Jiang, Binfeng Lu

Cell Rep. Author manuscript; available in PMC 2018 Jul 18.

Published in final edited form as: Cell Rep. 2018 May 8; 23(6): 1754–1766. doi: 10.1016/j.celrep.2018.04.032

PMCID:: PMC6051420

Abstract Article PDF–960K

Select item 582096511.

The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

Wael Bahnan, Justin C. Boucher, Petoria Gayle, Niraj Shrestha, Mark Rosen, Bertal Aktas, Becky Adkins, Arba Ager, Wasif N. Khan, Kurt Schesser

Infect Immun. 2018 Mar; 86(3): e00707-17. Prepublished online 2018 Jan 8. Published online 2018 Feb 20. doi: 10.1128/IAI.00707-17

PMCID:: PMC5820965

Abstract Article PDF–2.3M

Select item 581272912.

UBE2O remodels the proteome during terminal erythroid differentiation

Anthony T. Nguyen, Miguel A. Prado, Paul J. Schmidt, Anoop T. Sendamarai, Joshua T. Wilson-Grady, Mingwei Min, Dean R. Campagna, Geng Tian, Yuan Shi, Verena Dederer, Mona Kawan, Nathalie Kuehnle, Joao A. Paulo, Yu Yao, Mitchell J. Weiss, Monica J. Justice, Steven P. Gygi, Mark D. Fleming, Daniel Finley

Science. Author manuscript; available in PMC 2018 Feb 14.

Published in final edited form as: Science. 2017 Aug 4; 357(6350): eaan0218. doi: 10.1126/science.aan0218

PMCID:: PMC5812729

Abstract Article PDF–1.2M

Select item 579012613.

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Shuping Zhang, Alejandra Macias-Garcia, Jason Velazquez, Elena Paltrinieri, Randal J. Kaufman, Jane-Jane Chen

Blood. 2018 Jan 25; 131(4): 450–461. Prepublished online 2017 Nov 3. doi: 10.1182/blood-2017-08-799908

PMCID:: PMC5790126

Abstract Article

Select item 507228114.

Haem-regulated eIF2α kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency

Sijin Liu, Sanchita Bhattacharya, Anping Han, Rajasekhar N. V. S. Suragani, Wanting Zhao, Rebecca C. Fry, Jane-Jane Chen

Br J Haematol. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Br J Haematol. 2008 Oct; 143(1): 129–137. Published online 2008 Jul 28. doi: 10.1111/j.1365-2141.2008.07293.x

PMCID:: PMC5072281

Abstract Article PDF–1.3M

Select item 502575415.

Integrated stress response of vertebrates is regulated by four eIF2α kinases

Shusuke Taniuchi, Masato Miyake, Kazue Tsugawa, Miho Oyadomari, Seiichi Oyadomari

Sci Rep. 2016; 6: 32886. Published online 2016 Sep 16. doi: 10.1038/srep32886

PMCID:: PMC5025754

Abstract Article PDF–3.5M

Select item 441793516.

Constraint and divergence of global gene expression in the mammalian embryo

Noah Spies, Cheryl L Smith, Jesse M Rodriguez, Julie C Baker, Serafim Batzoglou, Arend Sidow

eLife. 2015; 4: e05538. Published online 2015 Apr 14. doi: 10.7554/eLife.05538

PMCID:: PMC4417935

Abstract Article PDF–2.0M

Select item 362107617.

Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE^−/− mice

Sijin Liu, Rajasekhar N.V.S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, Jane-Jane Chen

Haematologica. Author manuscript; available in PMC 2013 Apr 9.

Published in final edited form as: Haematologica. 2008 May; 93(5): 753–756. Published online 2008 Mar 26. doi: 10.3324/haematol.12175

PMCID:: PMC3621076

Abstract Article PDF–1.1M

Select item 347942918.

Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner

Tatiana Nedelko, Heike Kollmus, Frank Klawonn, Sabine Spijker, Lu Lu, Manuela Heßman, Rudi Alberts, Robert W Williams, Klaus Schughart

BMC Genomics. 2012; 13: 411. Published online 2012 Aug 20. doi: 10.1186/1471-2164-13-411

PMCID:: PMC3479429

Abstract Article PDF–1.9M

Select item 336961619.

Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

Rajasekhar N. V. S. Suragani, Roshini S. Zachariah, Jason G. Velazquez, Sijin Liu, Chiao-Wang Sun, Tim M. Townes, Jane-Jane Chen

Blood. 2012 May 31; 119(22): 5276–5284. Prepublished online 2012 Apr 12. doi: 10.1182/blood-2011-10-388132

PMCID:: PMC3369616

Abstract Article

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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