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Select item 110990151.

The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction

Xiaopan Gao, Bei Wang, Kaixiang Zhu, Linyue Wang, Bo Qin, Kun Shang, Wei Ding, Jianwei Wang, Sheng Cui

Nat Commun. 2024; 15: 4176. Published online 2024 May 16. doi: 10.1038/s41467-024-48504-w

PMCID:: PMC11099015

Abstract Article PDF–3.5M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 93185923.

Proteolytic Activities of Enterovirus 2A Do Not Depend on Its Interaction with SETD3

Xiaoyao Yang, Chiara Aloise, Arno L. W. van Vliet, Marleen Zwaagstra, Heyrhyoung Lyoo, Anchun Cheng, Frank J. M. van Kuppeveld

Viruses. 2022 Jul; 14(7): 1360. Published online 2022 Jun 22. doi: 10.3390/v14071360

PMCID:: PMC9318592

Abstract Article PDF–2.3M

Select item 92792854.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 90588365.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 87525726.

Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression

Tingting Zou, Yang Wang, Ling Dong, Tiantian Che, Huakan Zhao, Xiaohua Yan, Zhenghong Lin

Cell Mol Life Sci. 2022 Jan; 79(1): 70. Published online 2022 Jan 12. doi: 10.1007/s00018-021-04118-9

PMCID:: PMC8752572

Abstract Article PDF–6.8M

Select item 85138537.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74159859.

Characterization of SETD3 methyltransferase–mediated protein methionine methylation

Shaobo Dai, Matthew V. Holt, John R. Horton, Clayton B. Woodcock, Anamika Patel, Xing Zhang, Nicolas L. Young, Alex W. Wilkinson, Xiaodong Cheng

J Biol Chem. 2020 Aug 7; 295(32): 10901–10910. Published online 2020 Jun 5. doi: 10.1074/jbc.RA120.014072

PMCID:: PMC7415985

Abstract Article PDF–2.1M

Select item 704995510.

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation

Shaobo Dai, John R. Horton, Alex W. Wilkinson, Or Gozani, Xing Zhang, Xiaodong Cheng

J Biol Chem. 2020 Feb 28; 295(9): 2582–2589. Published online 2020 Jan 7. doi: 10.1074/jbc.RA119.012319

PMCID:: PMC7049955

Abstract Article PDF–2.2M

Select item 701074311.

SETD3 acts as a prognostic marker in breast cancer patients and modulates the viability and invasion of breast cancer cells

Nourhan Hassan, Niklas Rutsch, Balázs Győrffy, Nancy Adriana Espinoza-Sánchez, Martin Götte

Sci Rep. 2020; 10: 2262. Published online 2020 Feb 10. doi: 10.1038/s41598-020-59057-5

PMCID:: PMC7010743

Abstract Article PDF–3.7M

Select item 697103712.

Molecular basis for histidine N3-specific methylation of actin H73 by SETD3

Yihui Zheng, Xingrun Zhang, Haitao Li

Cell Discov. 2020; 6: 3. Published online 2020 Jan 21. doi: 10.1038/s41421-019-0135-5

PMCID:: PMC6971037

Article PDF–3.1M

Select item 668479813.

Structural basis for the target specificity of actin histidine methyltransferase SETD3

Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng

Nat Commun. 2019; 10: 3541. Published online 2019 Aug 6. doi: 10.1038/s41467-019-11554-6

PMCID:: PMC6684798

Abstract Article PDF–1.2M

Select item 651126314.

SETD3 is an Actin Histidine Methyltransferase that Prevents Primary Dystocia

Alex W. Wilkinson, Jonathan Diep, Shaobo Dai, Shuo Liu, Yaw shin Ooi, Dan Song, Tie-Mei Li, John R. Horton, Xing Zhang, Chao Liu, Darshan V. Trivedi, Katherine M. Ruppel, José G. Vilches-Moure, Kerriann M. Casey, Justin Mak, Tina Cowan, Joshua E. Elias, Claude M. Nagamine, James A. Spudich, Xiaodong Cheng, Jan E. Carette, Or Gozani

Nature. Author manuscript; available in PMC 2019 Jun 10.

Published in final edited form as: Nature. 2019 Jan; 565(7739): 372–376. Published online 2018 Dec 10. doi: 10.1038/s41586-018-0821-8

PMCID:: PMC6511263

Abstract Article PDF–4.9M

Select item 640049915.

Structural insights into SETD3-mediated histidine methylation on β-actin

Qiong Guo, Shanhui Liao, Sebastian Kwiatkowski, Weronika Tomaka, Huijuan Yu, Gao Wu, Xiaoming Tu, Jinrong Min, Jakub Drozak, Chao Xu

eLife. 2019; 8: e43676. Published online 2019 Feb 20. doi: 10.7554/eLife.43676

PMCID:: PMC6400499

Abstract Article PDF–1.3M

Select item 638547416.

CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth

Liangliang Xu, Xinfu Feng, Xiangyong Hao, Peng Wang, Yanfang Zhang, Xiaobo Zheng, Lian Li, Shengsheng Ren, Ming Zhang, Mingqing Xu

J Exp Clin Cancer Res. 2019; 38: 98. Published online 2019 Feb 22. doi: 10.1186/s13046-019-1041-2

PMCID:: PMC6385474

Abstract Article PDF–4.8M

Select item 634763817.

SETD3 is a positive regulator of DNA-damage-induced apoptosis

Elina Abaev-Schneiderman, Lee Admoni-Elisha, Dan Levy

Cell Death Dis. 2019 Feb; 10(2): 74. Published online 2019 Jan 25. doi: 10.1038/s41419-019-1328-4

PMCID:: PMC6347638

Abstract Article PDF–1.7M

Select item 628957418.

SETD3 protein is the actin-specific histidine N-methyltransferase

Sebastian Kwiatkowski, Agnieszka K Seliga, Didier Vertommen, Marianna Terreri, Takao Ishikawa, Iwona Grabowska, Marcel Tiebe, Aurelio A Teleman, Adam K Jagielski, Maria Veiga-da-Cunha, Jakub Drozak

eLife. 2018; 7: e37921. Published online 2018 Dec 11. doi: 10.7554/eLife.37921

PMCID:: PMC6289574

Abstract Article PDF–7.3M

Select item 567858119.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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