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Select item 111441941.

IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development

Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas

Nat Commun. 2024; 15: 4673. Published online 2024 Jun 1. doi: 10.1038/s41467-024-48854-5

PMCID:: PMC11144194

Abstract Article PDF–3.9M

Select item 105687852.

Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation

Yuanbang Lin, Mingwei Sheng, Hua Qin, Peng Zhang, Chunli Wang, Wei Fu, Xiangjun Meng, Duowei Wang, Yachao Hou

Cell Commun Signal. 2023; 21: 282. Published online 2023 Oct 12. doi: 10.1186/s12964-023-01287-x

PMCID:: PMC10568785

Abstract Article PDF–12M

Select item 101543333.

Histone demethylase KDM5B licenses macrophage-mediated inflammatory responses by repressing Nfkbia transcription

Yunkai Zhang, Ying Gao, Yuyu Jiang, Yingying Ding, Huiying Chen, Yan Xiang, Zhenzhen Zhan, Xingguang Liu

Cell Death Differ. 2023 May; 30(5): 1279–1292. Published online 2023 Mar 13. doi: 10.1038/s41418-023-01136-x

PMCID:: PMC10154333

Abstract Article PDF–4.9M

Select item 100124604.

Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα

Xuhui Ge, Zheng Zhou, Siting Yang, Wu Ye, Zhuanghui Wang, Jiaxing Wang, Chenyu Xiao, Min Cui, Jiawen Zhou, Yufeng Zhu, Rixiao Wang, Yu Gao, Haofan Wang, Pengyu Tang, Xuhui Zhou, Ce Wang, Weihua Cai

Cell Biosci. 2023; 13: 55. Published online 2023 Mar 13. doi: 10.1186/s13578-023-01011-9

PMCID:: PMC10012460

Abstract Article PDF–7.6M

Select item 99474245.

In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization

Yi Liu, Michael J. Trnka, Liang He, A.L. Burlingame, Maria Almira Correia

Mol Cell Proteomics. 2023 Feb; 22(2): 100495. Published online 2023 Jan 10. doi: 10.1016/j.mcpro.2023.100495

PMCID:: PMC9947424

Abstract Article PDF–5.0M

Select item 95886636.

HOXA5-mediated stabilization of IκB-α inhibits the NF-κB pathway and suppresses malignant transformation of breast epithelial cells

Priya Pai, Guannan Wang, Wei Wen Teo, Diana Raez-Rodriguez, Kathleen L. Gabrielson, Balázs Győrffy, Bradley M. Downs, Akanksha Aggarwal, Saraswati Sukumar

Cancer Res. Author manuscript; available in PMC 2023 Apr 17.

Published in final edited form as: Cancer Res. 2022 Oct 17; 82(20): 3802–3814. doi: 10.1158/0008-5472.CAN-21-4277

PMCID:: PMC9588663

Abstract Article PDF–2.5M

Select item 90145597.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 86275998.

NF-κB determines Paneth versus goblet cell fate decision in the small intestine

Cristina Brischetto, Karsten Krieger, Christian Klotz, Inge Krahn, Séverine Kunz, Marina Kolesnichenko, Patrick Mucka, Julian Heuberger, Claus Scheidereit, Ruth Schmidt-Ullrich

Development. 2021 Nov 1; 148(21): dev199683. Published online 2021 Nov 9. doi: 10.1242/dev.199683

PMCID:: PMC8627599

Abstract Article

Select item 84898559.

NFκB Dynamics Determine the Stimulus-Specificity of Epigenomic Reprogramming in Macrophages

Quen J. Cheng, Sho Ohta, Katherine M. Sheu, Roberto Spreafico, Adewunmi Adelaja, Brooks Taylor, Alexander Hoffmann

Science. Author manuscript; available in PMC 2021 Oct 4.

Published in final edited form as: Science. 2021 Jun 18; 372(6548): 1349–1353. doi: 10.1126/science.abc0269

PMCID:: PMC8489855

Abstract Article PDF–1.4M

Select item 822025410.

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

Lorenza Magno, Zeinab Asgarian, Valentina Pendolino, Theodora Velona, Albert Mackintosh, Flora Lee, Agata Stryjewska, Celine Zimmer, François Guillemot, Mark Farrant, Beverley Clark, Nicoletta Kessaris

Cell Rep. 2021 Jun 15; 35(11): 109249. Published online 2021 Jun 15. doi: 10.1016/j.celrep.2021.109249

PMCID:: PMC8220254

Abstract Article

Select item 818412711.

Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses

Adewunmi Adelaja, Brooks Taylor, Katherine M. Sheu, Yi Liu, Stefanie Luecke, Alexander Hoffmann

Immunity. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Immunity. 2021 May 11; 54(5): 916–930.e7. doi: 10.1016/j.immuni.2021.04.011

PMCID:: PMC8184127

Abstract Article PDF–3.0M

Select item 795742912.

Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence

Marina Kolesnichenko, Nadine Mikuda, Uta E Höpken, Eva Kärgel, Bora Uyar, Ahmet Bugra Tufan, Maja Milanovic, Wei Sun, Inge Krahn, Kolja Schleich, Linda von Hoff, Michael Hinz, Michael Willenbrock, Sabine Jungmann, Altuna Akalin, Soyoung Lee, Ruth Schmidt‐Ullrich, Clemens A Schmitt, Claus Scheidereit

EMBO J. 2021 Mar 15; 40(6): e104296. Published online 2021 Jan 18. doi: 10.15252/embj.2019104296

PMCID:: PMC7957429

Abstract Article PDF–1.5M

Select item 759808713.

Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency

Enrica E.K. Tan, Richard A. Hopkins, Chrissie K. Lim, Saumya S. Jamuar, Christina Ong, Koh C. Thoon, Mark J.A. Koh, Eun Mong Shin, Derrick W.Q. Lian, Madhushanee Weerasooriya, Christopher Z.W. Lee, Andreas Alvin Pumomo Soetedjo, Chang Siang Lim, Veonice B. Au, Edmond Chua, Hui Yin Lee, Leigh Ann Jones, Sharmy S. James, Nivashini Kaliaperumal, Jeffery Kwok, Ee Shien Tan, Biju Thomas, Lynn Xue Wu, Lena Ho, Anna Marie Fairhurst, Florent Ginhoux, Adrian K.K. Teo, Yong Liang Zhang, Kok Huar Ong, Weimiao Yu, Byrappa Venkatesh, Vinay Tergaonkar, Bruno Reversade, Keh Chuang Chin, Ah Moy Tan, Woei Kang Liew, John E. Connolly

J Clin Invest. 2020 Nov 2; 130(11): 5817–5832. Published online 2020 Sep 28. doi: 10.1172/JCI98882

PMCID:: PMC7598087

Abstract Article PDF–11M

Select item 736849414.

The sperm associated antigen 6 interactome and its role in spermatogenesis

Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang

Reproduction. Author manuscript; available in PMC 2020 Jul 18.

Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522

PMCID:: PMC7368494

Abstract Article PDF–1.8M

Select item 727164915.

IκBα deficiency imposes a fetal phenotype to intestinal stem cells

Laura Marruecos, Joan Bertran, Yolanda Guillén, Jéssica González, Raquel Batlle, Erika López‐Arribillaga, Marta Garrido, Cristina Ruiz‐Herguido, Dominique Lisiero, Mónica González‐Farré, Sara Arce‐Gallego, Mar Iglesias, Angel R Nebreda, Shigeki Miyamoto, Anna Bigas, Lluís Espinosa

EMBO Rep. 2020 Jun 4; 21(6): e49708. Published online 2020 Apr 9. doi: 10.15252/embr.201949708

PMCID:: PMC7271649

Abstract Article PDF–12M

Select item 717687816.

Silencing of ATP2B1‐AS1 contributes to protection against myocardial infarction in mouse via blocking NFKBIA‐mediated NF‐κB signalling pathway

Kai‐You Song, Xian‐Zhao Zhang, Feng Li, Qing‐Rong Ji

J Cell Mol Med. 2020 Apr; 24(8): 4466–4479. Published online 2020 Mar 10. doi: 10.1111/jcmm.15105

PMCID:: PMC7176878

Abstract Article PDF–1.0M

Select item 692769817.

Inhibition of lncRNA Neat1 by catalpol via suppressing transcriptional activity of NF-κB attenuates cardiomyocyte apoptosis

Guoliang Zou, Weili Zhong, Fan Wu, Xiaoxue Wang, Li Liu

Cell Cycle. 2019; 18(24): 3432–3441. Published online 2019 Nov 17. doi: 10.1080/15384101.2019.1673619

PMCID:: PMC6927698

Abstract Article PDF–1.9M

Select item 666883718.

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

Caitlin M. Braitsch, D. Berfin Azizoglu, Yadanar Htike, Haley R. Barlow, Ulrike Schnell, Christopher P. Chaney, Thomas J. Carroll, Ben Z. Stanger, Ondine Cleaver

PLoS Biol. 2019 Jul; 17(7): e3000382. Published online 2019 Jul 19. doi: 10.1371/journal.pbio.3000382

PMCID:: PMC6668837

Abstract Article PDF–6.1M

Select item 645693319.

Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome

Erica B Mahany, Xingfa Han, Beatriz C Borges, Sanseray da Silveira Cruz-Machado, Susan J Allen, David Garcia-Galiano, Mark J Hoenerhoff, Nicole H Bellefontaine, Carol F Elias

Endocrinology. 2018 Apr; 159(4): 1718–1733. Published online 2018 Feb 9. doi: 10.1210/en.2017-03053

PMCID:: PMC6456933

Abstract Article

Select item 641050820.

The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex

Pei-Rung Wu, Kathleen K.A. Cho, Daniel Vogt, Vikaas S. Sohal, John L.R. Rubenstein

Cereb Cortex. 2017 Sep; 27(9): 4303–4313. Published online 2016 Aug 6. doi: 10.1093/cercor/bhw230

PMCID:: PMC6410508

Abstract Article PDF–1.3M

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