PMC Links for GEO Profiles (Select 29225853) - PMC

Select item 78264511.

Ultra‐mutated colorectal cancer patients with POLE driver mutations exhibit distinct clinical patterns

Hanguang Hu, Wen Cai, Dehao Wu, Wangxiong Hu, Li Dong Wang, Jianshan Mao, Shu Zheng, Weiting Ge

Cancer Med. 2021 Jan; 10(1): 135–142. Published online 2020 Oct 30. doi: 10.1002/cam4.3579

PMCID:: PMC7826451

Abstract Article PDF–276K

Select item 74542382.

Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer

Shaobo Mo, Xiaoji Ma, Yaqi Li, Long Zhang, Ting Hou, Han Han-Zhang, Juanjuan Qian, Sanjun Cai, Dan Huang, Junjie Peng

J Immunother Cancer. 2020; 8(2): e000881. Published online 2020 Aug 27. doi: 10.1136/jitc-2020-000881

PMCID:: PMC7454238

Abstract Article PDF–2.1M

Select item 72394753.

High polymerase ε expression associated with increased CD8+T cells improves survival in patients with non-small cell lung cancer

Kyueng-Whan Min, Wan-Seop Kim, Dong-Hoon Kim, Byoung Kwan Son, Young Ha Oh, Mi Jung Kwon, Hye Seung Lee, Seung Eun Lee, In Ae Kim, Ji-Yong Moon, Kyoung-Yeon Kim, Jung-Hoon Park

PLoS One. 2020; 15(5): e0233066. Published online 2020 May 20. doi: 10.1371/journal.pone.0233066

PMCID:: PMC7239475

Abstract Article PDF–1.9M

Select item 59748774.

DNA Polymerase e - More Than a Polymerase

Helmut Pospiech, Juhani E. Syväoja

ScientificWorldJournal. 2003; 3: 87–104. Published online 2003 Mar 24. doi: 10.1100/tsw.2003.08

PMCID:: PMC5974877

Abstract PDF–1.0M

Select item 59431865.

Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1

Daniel D. Buchanan, Jenna R. Stewart, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Bernard J. Pope, Mark A. Jenkins, John L. Hopper, Melissa C. Southey, Finlay A. Macrae, Ingrid M. Winship, Aung Ko Win

Genet Med. Author manuscript; available in PMC 2018 Sep 21.

Published in final edited form as: Genet Med. 2018 Aug; 20(8): 890–895. Published online 2017 Nov 9. doi: 10.1038/gim.2017.185

Correction in:: Genet Med. 2018 Feb 1

PMCID:: PMC5943186

Abstract Article PDF–220K

Select item 59017726.

Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability

Tomoko Haruma, Takeshi Nagasaka, Keiichiro Nakamura, Junko Haraga, Akihiro Nyuya, Takeshi Nishida, Ajay Goel, Hisashi Masuyama, Yuji Hiramatsu

PLoS One. 2018; 13(4): e0195655. Published online 2018 Apr 16. doi: 10.1371/journal.pone.0195655

PMCID:: PMC5901772

Abstract Article PDF–11M

Select item 58979277.

Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1

Liang Liu, Jimmy Ruiz, Stacey S. O’Neill, Stefan C. Grant, W. Jeffrey Petty, Meng Yang, Kexin Chen, Umit Topaloglu, Boris Pasche, Wei Zhang

Mol Cancer. 2018; 17: 81. Published online 2018 Apr 12. doi: 10.1186/s12943-018-0832-y

PMCID:: PMC5897927

Abstract Article PDF–1.3M

Select item 58933648.

Molecular classification of grade 3 endometrioid endometrial cancers identifies distinct prognostic subgroups

Tjalling Bosse, Remi A. Nout, Jessica N. McAlpine, Melissa K. McConechy, Heidi Britton, Yaser Hussein, Carlene Gonzalez, Raji Ganesan, Jane C. Steele, Beth T. Harrison, Esther Oliva, August Vidal, Xavier Matias-Guiu, Nadeem R. Abu-Rustum, Douglas A. Levine, C. Blake Gilks, Robert A. Soslow

Am J Surg Pathol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Am J Surg Pathol. 2018 May; 42(5): 561–568. doi: 10.1097/PAS.0000000000001020

PMCID:: PMC5893364

Abstract Article PDF–725K

Select item 53565799.

The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

Sung-Min Ahn, Adnan Ahmad Ansari, Jihun Kim, Deokhoon Kim, Sung-Min Chun, Jiyun Kim, Tae Won Kim, Inja Park, Chang-Sik Yu, Se Jin Jang

Oncotarget. 2016 Oct 18; 7(42): 68638–68649. Published online 2016 Sep 6. doi: 10.18632/oncotarget.11862

PMCID:: PMC5356579

Abstract Article PDF–5.1M

Select item 501462510.

Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers

Nishi Kothari, Jamie K. Teer, Andrea M. Abbott, Thejal Srikumar, Yonghong Zhang, Sean J. Yoder, Andrew S. Brohl, Richard Kim, Damon R. Reed, David Shibata

Cancer. Author manuscript; available in PMC 2017 Sep 15.

Published in final edited form as: Cancer. 2016 Sep 15; 122(18): 2828–2835. Published online 2016 May 31. doi: 10.1002/cncr.30082

PMCID:: PMC5014625

Abstract Article PDF–958K

Select item 430493011.

Polymerase ε (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch Syndrome testing

Caroline C Billingsley, David E Cohn, David G Mutch, Julie A Stephens, Adrian A Suarez, Paul J Goodfellow

Cancer. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Cancer. 2015 Feb 1; 121(3): 386–394. Published online 2014 Sep 15. doi: 10.1002/cncr.29046

PMCID:: PMC4304930

Abstract Article PDF–674K

Select item 429837912.

Mutations in POLE and survival of colorectal cancer patients – link to disease stage and treatment

Albrecht Stenzinger, Nicole Pfarr, Volker Endris, Roland Penzel, Lina Jansen, Thomas Wolf, Esther Herpel, Arne Warth, Frederick Klauschen, Matthias Kloor, Wilfried Roth, Hendrik Bläker, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Wilko Weichert

Cancer Med. 2014 Dec; 3(6): 1527–1538. Published online 2014 Aug 1. doi: 10.1002/cam4.305

PMCID:: PMC4298379

Abstract Article PDF–330K

Select item 407916213.

A mutation in POLE predisposing to a multi-tumour phenotype

ANNA ROHLIN, THEOFANIS ZAGORAS, STAFFAN NILSSON, ULF LUNDSTAM, JAN WAHLSTRÖM, LEIF HULTÉN, TOMMY MARTINSSON, GÖRAN B. KARLSSON, MARGARETA NORDLING

Int J Oncol. 2014 Jul; 45(1): 77–81. Published online 2014 Apr 29. doi: 10.3892/ijo.2014.2410

PMCID:: PMC4079162

Abstract Article PDF–415K

Select item 369096714.

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

David N. Church, Sarah E.W. Briggs, Claire Palles, Enric Domingo, Stephen J. Kearsey, Jonathon M. Grimes, Maggie Gorman, Lynn Martin, Kimberley M. Howarth, Shirley V. Hodgson, The NSECG Collaborators, Kulvinder Kaur, Jenny Taylor, Ian P.M. Tomlinson

Hum Mol Genet. 2013 Jul 15; 22(14): 2820–2828. Published online 2013 Mar 24. doi: 10.1093/hmg/ddt131

PMCID:: PMC3690967

Abstract Article PDF–267K

Select item 336681615.

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

Andrey G. Baranovskiy, Artem G. Lada, Hollie M. Siebler, Yinbo Zhang, Youri I. Pavlov, Tahir H. Tahirov

J Biol Chem. 2012 May 18; 287(21): 17281–17287. Published online 2012 Mar 30. doi: 10.1074/jbc.M112.351122

PMCID:: PMC3366816

Abstract Article PDF–1.6M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 12717817.

Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ɛ*

Gabriel Birkuš, Miroslav Hájek, Pavel Kramata, Ivan Votruba, Antonín Holý, Berta Otová

Antimicrob Agents Chemother. 2002 May; 46(5): 1610–1613. doi: 10.1128/AAC.46.5.1610-1613.2002

PMCID:: PMC127178

Abstract Article PDF–125K

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