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Select item 109522391.

Endothelial PAR2 activation evokes resistance artery relaxation

Xun Zhang, Matthew D. Lee, Charlotte Buckley, Morley D. Hollenberg, Calum Wilson, John G. McCarron

J Cell Physiol. 2023 Apr; 238(4): 776–789. Published online 2023 Feb 15. doi: 10.1002/jcp.30973

PMCID:: PMC10952239

Abstract Article PDF–3.4M

Select item 91502942.

Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

Yiting Tang, Yupeng Chen, Mingzhu Yang, Qiuhui Zheng, Yaoyuan Li, Yanju Bao

BMC Musculoskelet Disord. 2022; 23: 514. Published online 2022 May 30. doi: 10.1186/s12891-022-05312-x

PMCID:: PMC9150294

Abstract Article PDF–3.6M

Select item 71021023.

Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury

Subrina Jesmin, Satoshi Gando, Sohel Zaedi, Fumika Sakuraya

Inflammation. 2007; 30(1): 14–27. Published online 2006 Nov 30. doi: 10.1007/s10753-006-9017-8

PMCID:: PMC7102102

Abstract Article PDF–1.2M

Select item 67551704.

Proteinase-activated receptor 2 deficiency is a protective factor against cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury

Min Wang, Yiwen Ma, Tiantian Zhang, Lin Gao, Shan Zhang, Qizhi Chen

Mol Med Rep. 2019 Oct; 20(4): 3764–3772. Published online 2019 Aug 26. doi: 10.3892/mmr.2019.10618

PMCID:: PMC6755170

Abstract Article PDF–972K

Select item 57675305.

Proteinase-Activated Receptor-2 Sensitivity of Amplified TRPA1 Activity in Skeletal Muscle Afferent Nerves and Exercise Pressor Reflex in Rats with Femoral Artery Occlusion

Jihong Xing, Jianhua Li

Cell Physiol Biochem. Author manuscript; available in PMC 2018 Feb 6.

Published in final edited form as: Cell Physiol Biochem. 2017; 44(1): 163–171. Published online 2017 Nov 6. doi: 10.1159/000484624

PMCID:: PMC5767530

Abstract Article PDF–1.1M

Select item 55039896.

Stress induces more serious barrier dysfunction in follicle-associated epithelium than villus epithelium involving mast cells and protease-activated receptor-2

Lei Zhang, Jun Song, Tao Bai, Wei Qian, Xiao-Hua Hou

Sci Rep. 2017; 7: 4950. Published online 2017 Jul 10. doi: 10.1038/s41598-017-05064-y

PMCID:: PMC5503989

Abstract Article PDF–15M

Select item 42551007.

Protease-Activated Receptor 2 Activation Inhibits N-Type Ca²⁺ Currents in Rat Peripheral Sympathetic Neurons

Young-Hwan Kim, Duck-Sun Ahn, Myeong Ok Kim, Ji-Hyun Joeng, Seungsoo Chung

Mol Cells. 2014 Nov 30; 37(11): 804–811. Published online 2014 Nov 10. doi: 10.14348/molcells.2014.0167

PMCID:: PMC4255100

Abstract Article PDF–1.1M

Select item 41354258.

Activation of the Cl⁻ Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP₃ Receptor

Xin Jin, Shihab Shah, Yani Liu, Huiran Zhang, Meredith Lees, Zhaojun Fu, Jonathan D. Lippiat, David J. Beech, Asipu Sivaprasadarao, Stephen A. Baldwin, Hailin Zhang, Nikita Gamper

Sci Signal. Author manuscript; available in PMC 2014 Aug 18.

Published in final edited form as: Sci Signal. 2013 Aug 27; 6(290): ra73. Published online 2013 Aug 27. doi: 10.1126/scisignal.2004184

PMCID:: PMC4135425

Abstract Article PDF–1.3M

Select item 40279949.

PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain

Yanju Bao, Wei Hou, Rui Liu, Yebo Gao, Xiangying Kong, Liping Yang, Zhan Shi, Weidong Li, Honggang Zheng, Shulong Jiang, Conghuang Li, Yinggang Qin, Baojin Hua

Mol Pain. 2014; 10: 28. Published online 2014 May 5. doi: 10.1186/1744-8069-10-28

PMCID:: PMC4027994

Abstract Article PDF–1.1M

Select item 399728010.

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways

Mahmoud El-Daly, Mahmoud Saifeddine, Koichiro Mihara, Rithwik Ramachandran, Christopher R Triggle, Morley D Hollenberg

Br J Pharmacol. 2014 May; 171(9): 2413–2425. Published online 2014 Apr 11. doi: 10.1111/bph.12593

PMCID:: PMC3997280

Abstract Article PDF–1.2M

Select item 361727011.

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease

Majedeline Belghiti, Judith Estévez-Herrera, Carla Giménez-Garzó, Alba González-Usano, Carmina Montoliu, Antonio Ferrer-Montiel, Vicente Felipo, Rosa Planells-Cases

J Biol Chem. 2013 Apr 5; 288(14): 9675–9685. Published online 2013 Feb 13. doi: 10.1074/jbc.M113.455162

PMCID:: PMC3617270

Abstract Article PDF–2.0M

Select item 361725512.

Renal Proteinase-activated Receptor 2, a New Actor in the Control of Blood Pressure and Plasma Potassium Level

Luciana Morla, Gaëlle Brideau, Marc Fila, Gilles Crambert, Lydie Cheval, Pascal Houillier, Sureshkrishna Ramakrishnan, Martine Imbert-Teboul, Alain Doucet

J Biol Chem. 2013 Apr 5; 288(14): 10124–10131. Published online 2013 Feb 19. doi: 10.1074/jbc.M112.446393

PMCID:: PMC3617255

Abstract Article PDF–1.1M

Select item 358137213.

Protease-activated Receptor 2 (PAR₂) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

Daniel P. Poole, Silvia Amadesi, Nicholas A. Veldhuis, Fe C. Abogadie, TinaMarie Lieu, William Darby, Wolfgang Liedtke, Michael J. Lew, Peter McIntyre, Nigel W. Bunnett

J Biol Chem. 2013 Feb 22; 288(8): 5790–5802. Published online 2013 Jan 3. doi: 10.1074/jbc.M112.438184

PMCID:: PMC3581372

Abstract Article PDF–3.1M

Select item 357256714.

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR₂) is involved in vascular function

M Bucci, V Vellecco, L Harrington, V Brancaleone, F Roviezzo, G Mattace Raso, A Ianaro, G Lungarella, R De Palma, R Meli, G Cirino

Br J Pharmacol. 2013 Jan; 168(2): 411–420. Published online 2012 Dec 20. doi: 10.1111/j.1476-5381.2012.02205.x

PMCID:: PMC3572567

Abstract Article PDF–709K

Select item 356270515.

Neutrophil proteinase 3 (PR3) acts on protease-activated receptor-2 (PAR-2) to enhance vascular endothelial cell barrier function

Christopher J. Kuckleburg, Peter J. Newman

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2): 275–284. Published online 2012 Nov 29. doi: 10.1161/ATVBAHA.112.300474

PMCID:: PMC3562705

Abstract Article PDF–4.5M

Select item 352586916.

Activation of PAR2 receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint

FA Russell, N Schuelert, VE Veldhoen, MD Hollenberg, JJ McDougall

Br J Pharmacol. 2012 Dec; 167(8): 1665–1678. Published online 2012 Nov 29. doi: 10.1111/j.1476-5381.2012.02120.x

PMCID:: PMC3525869

Abstract Article PDF–1.6M

Select item 334116617.

ALIX binds a YPX₃L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

Michael R. Dores, Buxin Chen, Huilan Lin, Unice J.K. Soh, May M. Paing, William A. Montagne, Timo Meerloo, JoAnn Trejo

J Cell Biol. 2012 Apr 30; 197(3): 407–419. doi: 10.1083/jcb.201110031

PMCID:: PMC3341166

Abstract Article PDF–3.6M

Select item 327672218.

Lesioning of TRPV1 Expressing Primary Afferent Neurons Prevents PAR-2 Induced Motility, but Not Mechanical Hypersensitivity in the Rat Colon

Shelby K. Suckow, Ethan M. Anderson, Robert M. Caudle

Neurogastroenterol Motil. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Neurogastroenterol Motil. 2012 Mar; 24(3): e125–e135. Published online 2011 Dec 13. doi: 10.1111/j.1365-2982.2011.01848.x

PMCID:: PMC3276722

Abstract Article PDF–1.0M

Select item 322320419.

Implantation Serine Proteinase 1 Exhibits Mixed Substrate Specificity that Silences Signaling via Proteinase-Activated Receptors

Navneet Sharma, Rajeev Kumar, Bernard Renaux, Mahmoud Saifeddine, Sandra Nishikawa, Koichiro Mihara, Rithwik Ramachandran, Morley D. Hollenberg, Derrick E. Rancourt

PLoS One. 2011; 6(11): e27888. Published online 2011 Nov 23. doi: 10.1371/journal.pone.0027888