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Items: 1 to 20 of 72

1.
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Nail Bouzalmad, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Philippe Pasero, Yea-Lih Lin
Nat Commun. 2024; 15: 5423. Published online 2024 Jun 26. doi: 10.1038/s41467-024-49740-w
PMCID:
PMC11208572
AbstractArticlePDF–1.6M
2.
TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids
Gabriela Goldberg, Luisa Coelho, Guoya Mo, Laura A. Adang, Meenakshi Patne, Zhoutao Chen, Ivan Garcia-Bassets, Pinar Mesci, Alysson R. Muotri
Mol Psychiatry. 2024; 29(3): 566–579. Published online 2023 Dec 21. doi: 10.1038/s41380-023-02348-w
PMCID:
PMC11153041
AbstractArticlePDF–2.8M
3.
Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W. Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, David C. Schultz, P. Toby Coates, Elisha D. O. Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner
Nat Commun. 2024; 15: 4696. Published online 2024 Jun 1. doi: 10.1038/s41467-024-49066-7
PMCID:
PMC11144269
AbstractArticlePDF–4.7M
4.
The Expression Levels of TREX1 and IFN-α Are Associated with Immune Reconstitution in HIV-1-Infected Individuals
Maria Alice Freitas Queiroz, Allysson Quintino Tenório de Oliveira, Tuane Carolina Ferreira Moura, Wandrey Roberto dos Santos Brito, Emmanuelle Giuliana Mendes Santana, Lorena Leticia Peixoto de Lima, Felipe Teixeira Lopes, Carlos David Araújo Bichara, Ednelza da Silva Graça Amoras, Ricardo Ishak, Izaura Maria Vieira Cayres Vallinoto, Antonio Carlos Rosário Vallinoto
Viruses. 2024 Apr; 16(4): 499. Published online 2024 Mar 25. doi: 10.3390/v16040499
PMCID:
PMC11054413
AbstractArticlePDF–4.1M
5.
TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals
Maria Alice Freitas Queiroz, Tuane Carolina Ferreira Moura, Carlos David Araújo Bichara, Lorena Leticia Peixoto de Lima, Allysson Quintino Tenório de Oliveira, Ranilda Gama de Souza, Samara Tatielle Monteiro Gomes, Ednelza da Silva Graça Amoras, Antonio Carlos Rosário Vallinoto
Int J Mol Sci. 2023 Jun; 24(11): 9660. Published online 2023 Jun 2. doi: 10.3390/ijms24119660
PMCID:
PMC10253649
AbstractArticlePDF–2.6M
6.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
7.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
8.
Structural basis of human TREX1 DNA degradation and autoimmune disease
Wen Zhou, Desmond Richmond-Buccola, Qiannan Wang, Philip J. Kranzusch
Nat Commun. 2022; 13: 4277. Published online 2022 Jul 25. doi: 10.1038/s41467-022-32055-z
PMCID:
PMC9314330
AbstractArticlePDF–1.8M
9.
Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro
Xiaoying Wei, Zhishuo Wang, Caroline Hinson, Kun Yang
Nucleic Acids Res. 2022 Apr 22; 50(7): 3638–3657. Published online 2022 Mar 29. doi: 10.1093/nar/gkac185
PMCID:
PMC9023300
AbstractArticlePDF–4.6M
10.
TREX1 degrades the 3′ end of the small DNA oligonucleotide products of nucleotide excision repair in human cells
Seon Hee Kim, Geun Hoe Kim, Michael G Kemp, Jun-Hyuk Choi
Nucleic Acids Res. 2022 Apr 22; 50(7): 3974–3984. Published online 2022 Mar 31. doi: 10.1093/nar/gkac214
PMCID:
PMC9023299
AbstractArticlePDF–3.8M
11.
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases
Jin Hu, Liudi Tang, Junjun Cheng, Tianlun Zhou, Yuhuan Li, Jinhong Chang, Qiong Zhao, Ju-Tao Guo
Emerg Microbes Infect. 2021; 10(1): 852–864. Published online 2021 May 1. doi: 10.1080/22221751.2021.1919034
PMCID:
PMC8812769
AbstractArticlePDF–1.7M
12.
Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma
Zhourui Ma, Qianwei Xiong, Hongliang Xia, Wei Liu, Shu Dai, Shizhong Cai, Zhenhong Zhu, Xiangming Yan
Bioengineered. 2021; 12(1): 6448–6458. Published online 2021 Sep 14. doi: 10.1080/21655979.2021.1972198
PMCID:
PMC8806763
AbstractArticlePDF–2.5M
13.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
14.
TREX1 as a Novel Immunotherapeutic Target
Wayne O. Hemphill, Sean R. Simpson, Mingyong Liu, Freddie R. Salsbury, Jr, Thomas Hollis, Jason M. Grayson, Fred W. Perrino
Front Immunol. 2021; 12: 660184. Published online 2021 Apr 1. doi: 10.3389/fimmu.2021.660184
PMCID:
PMC8047136
AbstractArticlePDF–3.2M
15.
TREX1 – Apex predator of cytosolic DNA metabolism
Sean R. Simpson, Wayne O. Hemphill, Teesha Hudson, Fred W. Perrino
DNA Repair (Amst) Author manuscript; available in PMC 2021 Mar 23.
Published in final edited form as: DNA Repair (Amst). 2020 Oct; 94: 102894. Published online 2020 Jun 12. doi: 10.1016/j.dnarep.2020.102894
PMCID:
PMC7985832
AbstractArticlePDF–1.1M
16.
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
Wen Zhou, Lisa Mohr, John Maciejowski, Philip J. Kranzusch
Mol Cell. Author manuscript; available in PMC 2022 Feb 18.
Published in final edited form as: Mol Cell. 2021 Feb 18; 81(4): 739–755.e7. doi: 10.1016/j.molcel.2021.01.024
PMCID:
PMC7899126
AbstractArticlePDF–4.2M
17.
ER-directed TREX1 limits cGAS activation at micronuclei
Lisa Mohr, Eléonore Toufektchan, Patrick von Morgen, Kevan Chu, Aakanksha Kapoor, John Maciejowski
Mol Cell. Author manuscript; available in PMC 2022 Feb 18.
Published in final edited form as: Mol Cell. 2021 Feb 18; 81(4): 724–738.e9. Published online 2021 Jan 20. doi: 10.1016/j.molcel.2020.12.037
PMCID:
PMC7897315
AbstractArticlePDF–2.4M
18.
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
John Maciejowski, Aikaterini Chatzipli, Alexandra Dananberg, Kevan Chu, Eleonore Toufektchan, Leszek J. Klimczak, Dmitry A. Gordenin, Peter J. Campbell, Titia de Lange
Nat Genet. Author manuscript; available in PMC 2021 Jan 27.
Published in final edited form as: Nat Genet. 2020 Sep; 52(9): 884–890. Published online 2020 Jul 27. doi: 10.1038/s41588-020-0667-5
PMCID:
PMC7484228
AbstractArticlePDF–3.9M
19.
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets
Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier, Beverly A. Teicher
Clin Epigenetics. 2020; 12: 93. Published online 2020 Jun 25. doi: 10.1186/s13148-020-00876-8
PMCID:
PMC7318526
AbstractArticlePDF–1.6M
20.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M

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