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Items: 1 to 20 of 307

1.
Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication
Huisheng Liu, Qiao Xue, Fan Yang, Weijun Cao, Pengfei Liu, Xiangtao Liu, Zixiang Zhu, Haixue Zheng
Autophagy. 2024; 20(7): 1597–1615. Published online 2024 Mar 22. doi: 10.1080/15548627.2024.2330105
PMCID:
PMC11210904
AbstractArticlePDF–4.1M
2.
AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin’s acute effects
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Natalia L. S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Linus Tsai, Evan D. Rosen
Nat Commun. 2024; 15: 4646. Published online 2024 May 31. doi: 10.1038/s41467-024-48885-y
PMCID:
PMC11143326
AbstractArticlePDF–5.3M
3.
Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels
Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel A. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen
Nat Commun. 2024; 15: 4605. Published online 2024 May 30. doi: 10.1038/s41467-024-48220-5
PMCID:
PMC11139994
AbstractArticlePDF–2.9M
4.
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri
Nat Commun. 2024; 15: 4099. Published online 2024 May 30. doi: 10.1038/s41467-024-48441-8
PMCID:
PMC11139893
AbstractArticlePDF–2.6M
5.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
6.
Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains
Ines Ambite, Thi Hien Tran, Daniel S. C. Butler, Michele Cavalera, Murphy Lam Yim Wan, Shahram Ahmadi, Catharina Svanborg
Pathogens. 2024 Jan; 13(1): 42. Published online 2023 Dec 31. doi: 10.3390/pathogens13010042
PMCID:
PMC10820880
AbstractArticlePDF–4.1M
7.
ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus
Biao Chen, Guijie Guo, Guoqing Wang, Qianwen Zhu, Lulu Wang, Wenhao Shi, Song Wang, Yuhai Chen, Xiaojuan Chi, Faxin Wen, Mohamed Maarouf, Shile Huang, Zhou Yang, Ji-Long Chen
PLoS Pathog. 2024 Jan; 20(1): e1011958. Published online 2024 Jan 16. doi: 10.1371/journal.ppat.1011958
PMCID:
PMC10817227
AbstractArticlePDF–4.0M
8.
Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo
Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli
PLoS Pathog. 2023 Sep; 19(9): e1011446. Published online 2023 Sep 21. doi: 10.1371/journal.ppat.1011446
PMCID:
PMC10547207
AbstractArticlePDF–2.4M
9.
Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection
Loreen Weichert, Henning Peter Düsedau, David Fritzsch, Sarah Schreier, Annika Scharf, Martina Grashoff, Kristin Cebulski, Kristin Michaelsen-Preusse, Christian Erck, Stefan Lienenklaus, Ildiko Rita Dunay, Andrea Kröger
J Neuroinflammation. 2023; 20: 213. Published online 2023 Sep 22. doi: 10.1186/s12974-023-02892-w
PMCID:
PMC10515022
AbstractArticlePDF–7.2M
10.
IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Cells. 2023 Jun; 12(11): 1493. Published online 2023 May 28. doi: 10.3390/cells12111493
PMCID:
PMC10252328
AbstractArticlePDF–2.9M
11.
Identification and characterization of small molecule IRF3-dependent immune activators for pharmaceutical development
Marie H. Foss, Susan L. Stevens, Haihong Jin, Elyse M. Allen, Dylan Nelson, Victor DeFilippis, Aaron Nilsen, Mary P. Stenzel-Poore
ACS Chem Biol. Author manuscript; available in PMC 2023 May 20.
Published in final edited form as: ACS Chem Biol. 2022 May 20; 17(5): 1073–1081. Published online 2022 Apr 26. doi: 10.1021/acschembio.1c00912
PMCID:
PMC10064657
AbstractArticlePDF–1.2M
12.
Pim1 promotes IFN-β production by interacting with IRF3
Ryeojin Ko, Jeongin Seo, Hana Park, Nawon Lee, Soo Young Lee
Exp Mol Med. 2022 Nov; 54(11): 2092–2103. Published online 2022 Nov 29. doi: 10.1038/s12276-022-00893-y
PMCID:
PMC9722908
AbstractArticlePDF–3.5M
13.
IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation
Sonam Popli, Sukanya Chakravarty, Shumin Fan, Anna Glanz, Siddhesh Aras, Laura E. Nagy, Ganes C. Sen, Ritu Chakravarti, Saurabh Chattopadhyay
Proc Natl Acad Sci U S A. 2022 Sep 13; 119(37): e2121385119. Published online 2022 Sep 6. doi: 10.1073/pnas.2121385119
PMCID:
PMC9478676
AbstractArticlePDF–2.1M
14.
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit
Immunity. Author manuscript; available in PMC 2023 Sep 13.
Published in final edited form as: Immunity. 2022 Aug 10 : S1074-7613(22)00340-5. Published online 2022 Aug 10. doi: 10.1016/j.immuni.2022.07.007
PMCID:
PMC9474643
AbstractArticlePDF–3.6M
15.
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M.C. Böhner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A.I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Rösen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
J Exp Med. 2022 Oct 3; 219(10): e20220759. Published online 2022 Aug 23. doi: 10.1084/jem.20220759
Correction in:
J Exp Med. 2022 Dec 5; 219(12): e2022075911022022c.
PMCID:
PMC9402992
AbstractArticlePDF–6.5M
16.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Sci Transl Med. Author manuscript; available in PMC 2022 Jun 2.
Published in final edited form as: Sci Transl Med. 2022 Mar 23; 14(637): eabh3831. Published online 2022 Mar 23. doi: 10.1126/scitranslmed.abh3831
PMCID:
PMC9162056
AbstractArticlePDF–3.1M
17.
Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses
Alyssa B. Evans, Clayton W. Winkler, Karin E. Peterson
PLoS Pathog. 2022 Mar; 18(3): e1010384. Published online 2022 Mar 4. doi: 10.1371/journal.ppat.1010384
PMCID:
PMC8926202
AbstractArticlePDF–4.0M
18.
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response
Xinwei Geng, Chao Zhang, Miao Li, Jiaqi Wang, Fang Ji, Hanrong Feng, Meichun Xing, Fei Li, Lingling Zhang, Wen Li, Zhihua Chen, Ian D. Hickson, Huahao Shen, Songmin Ying
Adv Sci (Weinh) 2022 Mar; 9(7): 2103837. Published online 2022 Jan 17. doi: 10.1002/advs.202103837
PMCID:
PMC8895048
AbstractArticlePDF–3.9M
19.
The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma
Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris
Haematologica. 2022 Mar 1; 107(3): 721–732. Published online 2021 Feb 18. doi: 10.3324/haematol.2020.274480
PMCID:
PMC8883568
AbstractArticlePDF–1.9M
20.
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium
Jacob A Van Winkle, Stefan T Peterson, Elizabeth A Kennedy, Michael J Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A Constant, Austin P Wright, Lena Li, Maxim N Artyomov, Sanghyun Lee, Megan T Baldridge, Timothy J Nice
eLife. 2022; 11: e74072. Published online 2022 Feb 9. doi: 10.7554/eLife.74072
PMCID:
PMC8853662
AbstractArticlePDF–21M

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