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Select item 114677941.

The selenoenzyme type I iodothyronine deiodinase: a new tumor suppressor in ovarian cancer

Adi Alfandari, Dotan Moskovich, Avivit Weisz, Aviva Katzav, Debora Kidron, Mario Beiner, Dana Josephy, Aula Asali, Yael Hants, Yael Yagur, Omer Weitzner, Martin Ellis, Gilad Itchaki, Osnat Ashur‐Fabian

Mol Oncol. 2024 Sep; 18(9): 2298–2313. Published online 2024 Mar 1. doi: 10.1002/1878-0261.13612

PMCID:: PMC11467794

Abstract Article PDF–7.9M

Select item 108705852.

A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells

Casimiro Castillejo-López, José Ramón Bárcenas-Walls, Marco Cavalli, Anders Larsson, Claes Wadelius

Lipids Health Dis. 2024; 23: 48. Published online 2024 Feb 16. doi: 10.1186/s12944-024-02029-9

PMCID:: PMC10870585

Abstract Article PDF–1.2M

Select item 104137663.

SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Rowan AlEjielat, Anas Khaleel, Yazan S. Batarseh, Luay Abu-Qatouseh, Suzan Al-Wawi, Toleen AlSunna

BMC Endocr Disord. 2023; 23: 167. Published online 2023 Aug 10. doi: 10.1186/s12902-023-01425-z

PMCID:: PMC10413766

Abstract Article PDF–1022K

Select item 89178824.

Novel DIO1 Gene Mutation Acting as Phenotype Modifier for Novel Compound Heterozygous TPO Gene Mutations Causing Congenital Hypothyroidism

Aryel Furman, Zeina Hannoush, Francisco Barrera Echegoyen, Alexandra Dumitrescu, Samuel Refetoff, Roy E. Weiss

Thyroid. October 2021; 31(10): 1589–1591. Published online 2021 Oct 18. doi: 10.1089/thy.2021.0210

PMCID:: PMC8917882

Abstract Article PDF–260K

Select item 78912005.

Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism

Monica M. França, Alina German, Gustavo W. Fernandes, Xiao-Hui Liao, Antonio C. Bianco, Samuel Refetoff, Alexandra M. Dumitrescu

Thyroid. February 2021; 31(2): 202–207. Published online 2021 Feb 12. doi: 10.1089/thy.2020.0253

PMCID:: PMC7891200

Abstract Article PDF–377K

Select item 75668816.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 61663387.

The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome

Shu-Lan Qin, Qi He, Ling Hu, Chun-Yan He, Li-Cheng Gao, Charlotte Aimee Young, Juan Chen, Cheng-Fang Jiang, Xiang-Feng Luo, Ying Zhou, Xia Sheng, Zhi-Hong Li, Mei-Ling Chen, Gaosi Xu

J Int Med Res. 2018 Oct; 46(10): 4061–4070. Published online 2018 Aug 28. doi: 10.1177/0300060518778190

PMCID:: PMC6166338

Abstract Article PDF–404K

Select item 57412488.

Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system

Piotr Popławski, Jacek R. Wiśniewski, Eddy Rijntjes, Keith Richards, Beata Rybicka, Josef Köhrle, Agnieszka Piekiełko-Witkowska

PLoS One. 2017; 12(12): e0190179. Published online 2017 Dec 22. doi: 10.1371/journal.pone.0190179

PMCID:: PMC5741248

Abstract Article PDF–8.8M

Select item 54723099.

Regulation of type 1 iodothyronine deiodinase by LXRα

Yoriko Sakane, Naotetsu Kanamoto, Ichiro Yamauchi, Tetsuya Tagami, Yusuke Morita, Masako Miura, Masakatsu Sone, Akihiro Yasoda, Takeshi Kimura, Kazuwa Nakao, Nobuya Inagaki

PLoS One. 2017; 12(6): e0179213. Published online 2017 Jun 15. doi: 10.1371/journal.pone.0179213

PMCID:: PMC5472309

Abstract Article PDF–7.7M

Select item 505663010.

The CCND1 870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Niels Weinhold, David C Johnson, Daniel Chubb, Bowang Chen, Asta Försti, Fay J Hosking, Peter Broderick, Yussanne P Ma, Sara E Dobbins, Dirk Hose, Brian A Walker, Faith E Davies, Martin F Kaiser, Ni L Li, Walter A Gregory, Graham H Jackson, Mathias Witzens-Harig, Kai Neben, Per Hoffmann, Markus M Nöthen, Thomas W Mühleisen, Lewin Eisele, Fiona M Ross, Anna Jauch, Hartmut Goldschmidt, Richard S Houlston, Gareth J Morgan, Kari Hemminki

Nat Genet. Author manuscript; available in PMC 2016 Oct 10.

Published in final edited form as: Nat Genet. 2013 May; 45(5): 522–525. Published online 2013 Mar 17. doi: 10.1038/ng.2583

PMCID:: PMC5056630

Abstract Article PDF–483K

Select item 361296911.

Catalysis leads to post-translational inactivation of the Type 1 deiodinase and alters its conformation

Bo Zhu, Ashutosh Shrivastava, Cristina Luongo, Ting Chen, John W. Harney, Alessandro Marsili, Thuy-Van Tran, Anulika Bhadouria, Radhika Mopala, Amanda I. Steen, P. Reed Larsen, Ann Marie Zavacki

J Endocrinol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: J Endocrinol. 2012 Jul; 214(1): 87–94. Published online 2012 Apr 27. doi: 10.1530/JOE-11-0459

PMCID:: PMC3612969

Abstract Article PDF–589K

Select item 356717512.

A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function

Eleonora Porcu, Marco Medici, Giorgio Pistis, Claudia B. Volpato, Scott G. Wilson, Anne R. Cappola, Steffan D. Bos, Joris Deelen, Martin den Heijer, Rachel M. Freathy, Jari Lahti, Chunyu Liu, Lorna M. Lopez, Ilja M. Nolte, Jeffrey R. O'Connell, Toshiko Tanaka, Stella Trompet, Alice Arnold, Stefania Bandinelli, Marian Beekman, Stefan Böhringer, Suzanne J. Brown, Brendan M. Buckley, Clara Camaschella, Anton J. M. de Craen, Gail Davies, Marieke C. H. de Visser, Ian Ford, Tom Forsen, Timothy M. Frayling, Laura Fugazzola, Martin Gögele, Andrew T. Hattersley, Ad R. Hermus, Albert Hofman, Jeanine J. Houwing-Duistermaat, Richard A. Jensen, Eero Kajantie, Margreet Kloppenburg, Ee M. Lim, Corrado Masciullo, Stefano Mariotti, Cosetta Minelli, Braxton D. Mitchell, Ramaiah Nagaraja, Romana T. Netea-Maier, Aarno Palotie, Luca Persani, Maria G. Piras, Bruce M. Psaty, Katri Räikkönen, J. Brent Richards, Fernando Rivadeneira, Cinzia Sala, Mona M. Sabra, Naveed Sattar, Beverley M. Shields, Nicole Soranzo, John M. Starr, David J. Stott, Fred C. G. J. Sweep, Gianluca Usala, Melanie M. van der Klauw, Diana van Heemst, Alies van Mullem, Sita H.Vermeulen, W. Edward Visser, John P. Walsh, Rudi G. J. Westendorp, Elisabeth Widen, Guangju Zhai, Francesco Cucca, Ian J. Deary, Johan G. Eriksson, Luigi Ferrucci, Caroline S. Fox, J. Wouter Jukema, Lambertus A. Kiemeney, Peter P. Pramstaller, David Schlessinger, Alan R. Shuldiner, Eline P. Slagboom, André G. Uitterlinden, Bijay Vaidya, Theo J. Visser, Bruce H. R. Wolffenbuttel, Ingrid Meulenbelt, Jerome I. Rotter, Tim D. Spector, Andrew A. Hicks, Daniela Toniolo, Serena Sanna, Robin P. Peeters, Silvia Naitza

PLoS Genet. 2013 Feb; 9(2): e1003266. Published online 2013 Feb 7. doi: 10.1371/journal.pgen.1003266

PMCID:: PMC3567175

Abstract Article PDF–1.6M

Select item 323603413.

The Relationship of Deiodinase 1 Genotype and Thyroid Function to Lifetime History of Major Depression in Three Independent Populations

Robert A. Philibert, Steven R. H. Beach, Tracy D. Gunter, Alexandre A. Todorov, Gene H. Brody, Meeshanthini Vijayendran, Lilly Elliott, Nancy Hollenbeck, Daniel Russell, Carolyn Cutrona

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2011 Jul; 156(5): 593–599. Published online 2011 May 11. doi: 10.1002/ajmg.b.31200

PMCID:: PMC3236034

Abstract Article PDF–145K

Select item 322018614.

Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes

Lin T. Guey, Montserrat García-Closas, Cristiane Murta-Nascimento, Josep Lloreta, Laia Palencia, Manolis Kogevinas, Nathaniel Rothman, Gemma Vellalta, Malu Calle, Gaëlle Marenne, Adonina Tardón, Alfredo Carrato, Reina García-Closas, Consol Serra, Debra T Silverman, Stephen Chanock, Francisco X. Real, Núria Malats

Eur Urol. Author manuscript; available in PMC 2011 Nov 18.

Published in final edited form as: Eur Urol. 2010 Feb; 57(2): 283–292. Published online 2009 Aug 12. doi: 10.1016/j.eururo.2009.08.001

PMCID:: PMC3220186

Abstract Article PDF–595K

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316632616.

MiR-224 Targets the 3′UTR of Type 1 5′-Iodothyronine Deiodinase Possibly Contributing to Tissue Hypothyroidism in Renal Cancer

Joanna Boguslawska, Anna Wojcicka, Agnieszka Piekielko-Witkowska, Adam Master, Alicja Nauman

PLoS One. 2011; 6(9): e24541. Published online 2011 Sep 2. doi: 10.1371/journal.pone.0024541

PMCID:: PMC3166326

Abstract Article PDF–411K

Select item 281626217.

The Enzymatic Activity of Type 1 Iodothyronine Deiodinase (D1) is Low in Liver Hemangioma: A Preliminary Study

Oskar Kornasiewicz, Marcin Debski, Marta Stepnowska, Anna Szałas, Ewa Bar-Andziak, Marek Krawczyk

Arch Immunol Ther Exp (Warsz) 2010 Feb; 58(1): 77–80. Published online 2010 Jan 5. doi: 10.1007/s00005-009-0056-3

PMCID:: PMC2816262

Abstract Article PDF–176K

Select item 278379918.

PTEN IDENTIFIED AS IMPORTANT RISK FACTOR OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

H Dean Hosgood, III, Idan Menashe, Xingzhou He, Stephen Chanock, Qing Lan

Respir Med. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Respir Med. 2009 Dec; 103(12): 1866–1870. Published online 2009 Jul 21. doi: 10.1016/j.rmed.2009.06.016

PMCID:: PMC2783799

Abstract Article PDF–315K

Select item 272779319.

The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors

Iñigo Landa, Sergio Ruiz-Llorente, Cristina Montero-Conde, Lucía Inglada-Pérez, Francesca Schiavi, Susanna Leskelä, Guillermo Pita, Roger Milne, Javier Maravall, Ignacio Ramos, Víctor Andía, Paloma Rodríguez-Poyo, Antonino Jara-Albarrán, Amparo Meoro, Cristina del Peso, Luis Arribas, Pedro Iglesias, Javier Caballero, Joaquín Serrano, Antonio Picó, Francisco Pomares, Gabriel Giménez, Pedro López-Mondéjar, Roberto Castello, Isabella Merante-Boschin, Maria-Rosa Pelizzo, Didac Mauricio, Giuseppe Opocher, Cristina Rodríguez-Antona, Anna González-Neira, Xavier Matías-Guiu, Pilar Santisteban, Mercedes Robledo

PLoS Genet. 2009 Sep; 5(9): e1000637. Published online 2009 Sep 4. doi: 10.1371/journal.pgen.1000637

PMCID:: PMC2727793

Abstract Article PDF–518K

Select item 272285720.

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway

H.Dean Hosgood, III, Idan Menashe, Min Shen, Meredith Yeager, Jeff Yuenger, Preetha Rajaraman, Xingzhou He, Nilanjan Chatterjee, Neil E. Caporaso, Yong Zhu, Stephen J. Chanock, Tongzhang Zheng, Qing Lan

Carcinogenesis. 2008 Oct; 29(10): 1938–1943. Published online 2008 Aug 1. doi: 10.1093/carcin/bgn178

PMCID:: PMC2722857

Abstract Article PDF–181K

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