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Select item 112612901.

Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma

Christopher D. Green, Ryan D.R. Brown, Baasanjav Uranbileg, Cynthia Weigel, Sumit Saha, Makoto Kurano, Yutaka Yatomi, Sarah Spiegel

Mol Metab. 2024 Aug; 86: 101971. Published online 2024 Jun 24. doi: 10.1016/j.molmet.2024.101971

PMCID:: PMC11261290

Abstract Article PDF–4.8M

Select item 100471542.

Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma

Jian Wu, Shengjun Fan, Daniel Feinberg, Xiaobei Wang, Shaima Jabbar, Yubin Kang

Curr Oncol. 2023 Mar; 30(3): 3047–3063. Published online 2023 Mar 4. doi: 10.3390/curroncol30030231

PMCID:: PMC10047154

Abstract Article PDF–5.1M

Select item 99891533.

Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes

Gulibositan Aji, Sheng Jiang, Halmurat Obulkasim, Zhiqiang Lu, Wei Wang, Pu Xia

Exp Biol Med (Maywood) 2023 Jan; 248(1): 44–51. Published online 2022 Nov 20. doi: 10.1177/15353702221131886

PMCID:: PMC9989153

Abstract Article PDF–1.7M

Select item 94510604.

Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection

Mengqiong Xu, Sisi Xia, Mei Wang, Xiaolian Liu, Xin Li, Weijie Chen, Yaohao Wang, Hongjian Li, Chuan Xia, Jun Chen, Jianguo Wu

PLoS Pathog. 2022 Sep; 18(9): e1010794. Published online 2022 Sep 7. doi: 10.1371/journal.ppat.1010794

PMCID:: PMC9451060

Abstract Article PDF–3.6M

Select item 93947715.

Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury

Dengpiao Xie, Gaizun Hu, Chaoling Chen, Fereshteh Ahmadinejad, Weili Wang, Pin-Lan Li, David A. Gewirtz, Ningjun Li

Am J Physiol Renal Physiol. 2022 Sep 1; 323(3): F322–F334. Published online 2022 Jul 13. doi: 10.1152/ajprenal.00229.2021

PMCID:: PMC9394771

Abstract Article

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 82926297.

Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy

Hongliang Wang, Bing Zhao, Erbao Bian, Gang Zong, Jie He, Yuyang Wang, Chunchun Ma, Jinghai Wan

Front Cell Neurosci. 2021; 15: 660354. Published online 2021 Jul 7. doi: 10.3389/fncel.2021.660354

PMCID:: PMC8292629

Abstract Article PDF–5.2M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78447309.

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

Geqiong Xiao, Qiong Wang, Bo Li, Xiaohui Wu, Hui Liao, Yili Ren, Ning Ai

Oncol Res. 2018; 26(8): 1183–1189. Published online 2018 Sep 14. doi: 10.3727/096504018X15151495109394

PMCID:: PMC7844730

Abstract Article PDF–14M

Select item 741552210.

Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukemia and promotes survival through Mcl-1

Francis R LeBlanc, Jennifer M Pearson, Su-Fern Tan, HeeJin Cheon, Jeffrey C. Xing, Wendy Dunton, David J Feith, Thomas P Loughran, Jr

Br J Haematol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Br J Haematol. 2020 Aug; 190(3): 405–417. Published online 2020 Mar 2. doi: 10.1111/bjh.16530

PMCID:: PMC7415522

Abstract Article PDF–1.5M

Select item 741133411.

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhang

Mol Med Rep. 2020 Sep; 22(3): 2573–2582. Published online 2020 Jul 9. doi: 10.3892/mmr.2020.11313

PMCID:: PMC7411334

Abstract Article PDF–1.2M

Select item 732206712.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 694919213.

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P₂ modulation

Gennaro Bruno, Francesca Cencetti, Alessandro Pini, Annalisa Tondo, Daniela Cuzzubbo, Filippo Fontani, Vanessa Strinna, Anna Maria Buccoliero, Gabriella Casazza, Chiara Donati, Luca Filippi, Paola Bruni, Claudio Favre, Maura Calvani

Oncogene. 2020; 39(2): 368–384. Published online 2019 Sep 2. doi: 10.1038/s41388-019-0993-1

PMCID:: PMC6949192

Abstract Article PDF–6.6M

Select item 693812914.

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis

Pascale Blais-Lecours, Sofien Laouafa, Christian Arias-Reyes, Webster L. Santos, Vincent Joseph, Janette K. Burgess, Andrew J. Halayko, Jorge Soliz, David Marsolais

Am J Respir Cell Mol Biol. 2020 Jan; 62(1): 35–42. doi: 10.1165/rcmb.2018-0397OC

PMCID:: PMC6938129

Abstract Article PDF–895K

Select item 668242615.

The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease

Eric K. Kwong, Runping Liu, Derrick Zhao, Xiaojiaoyang Li, Weiwei Zhu, Xuan Wang, Emily C. Gurley, Guanhua Lai, Jimin Liu, Phillip B. Hylemon, Huiping Zhou

Dig Liver Dis. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Dig Liver Dis. 2019 Aug; 51(8): 1154–1163. Published online 2019 Apr 16. doi: 10.1016/j.dld.2019.03.020

PMCID:: PMC6682426

Abstract Article PDF–1.4M

Select item 640456816.

Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes

Ziyu Song, Wei Wang, Ning Li, Sishan Yan, Kuan Rong, Tian Lan, Pu Xia

FASEB J. 2019 Mar; 33(3): 3636–3646. Published online 2018 Nov 19. doi: 10.1096/fj.201801496R

PMCID:: PMC6404568

Abstract Article

Select item 636364717.

Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma

Heidi A. Neubauer, Melinda N. Tea, Julia R. Zebol, Briony L. Gliddon, Cassandra Stefanidis, Paul A. B. Moretti, Melissa R. Pitman, Maurizio Costabile, Jasreen Kular, Brett W. Stringer, Bryan W. Day, Michael S. Samuel, Claudine S. Bonder, Jason A. Powell, Stuart M. Pitson

Oncogene. 2019; 38(8): 1151–1165. Published online 2018 Sep 24. doi: 10.1038/s41388-018-0504-9

PMCID:: PMC6363647

Abstract Article PDF–2.9M

Select item 634264118.

Both sphingosine kinase 1 and 2 coordinately regulate cathelicidin antimicrobial peptide production during keratinocyte differentiation

Kyong-Oh Shin, Kun Pyo Kim, Yunhi Cho, Min-Kyung Kang, Young-Hee Kang, Yong-Moon Lee, Hiroko Ikushiro, Mami Yokota, Takato Yano, Sung Jay Choe, Eung Ho Choi, Chae Jin Lim, Keedon Park, Walter M. Holleran, Kyungho Park, Yoshikazu Uchida

J Invest Dermatol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: J Invest Dermatol. 2019 Feb; 139(2): 492–494. Published online 2018 Sep 15. doi: 10.1016/j.jid.2018.08.015

PMCID:: PMC6342641

Abstract Article PDF–681K

Select item 619281819.

Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells

NESMA NABIL IBRAHIM MOHAMED, TARO OKADA, TAKETOSHI KAJIMOTO, SHUN-ICHI NAKAMURA

Kobe J Med Sci. 2017; 63(4): E123–E129. Published online 2018 May 25.

PMCID:: PMC6192818

Abstract Article PDF–2.8M

Select item 612534420.

Sphingosine Kinases promote IL-17 expression in human T lymphocytes

Giusi Barra, Alessio Lepore, Miriam Gagliardi, Domenico Somma, Maria Rosaria Matarazzo, Francesca Costabile, Giuseppe Pasquale, Alessio Mazzoni, Carmela Gallo, Genoveffa Nuzzo, Francesco Annunziato, Angelo Fontana, Antonio Leonardi, Raffaele De Palma

Sci Rep. 2018; 8: 13233. Published online 2018 Sep 5. doi: 10.1038/s41598-018-31666-1

PMCID:: PMC6125344

Abstract Article PDF–2.0M

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