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Items: 1 to 20 of 215

1.
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
Ming-Hsuan Ou-Yang, Jonathan E. Kurz, Toshihiro Nomura, Jelena Popovic, Tharinda W. Rajapaksha, Hongxin Dong, Anis Contractor, Dane M. Chetkovich, Warren G. Tourtellotte, Robert Vassar
Sci Transl Med. Author manuscript; available in PMC 2024 Apr 15.
Published in final edited form as: Sci Transl Med. 2018 Sep 19; 10(459): eaao5620. doi: 10.1126/scitranslmed.aao5620
PMCID:
PMC11017370
AbstractArticlePDF–2.3M
2.
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
Yifan Wu, Shuqi Du, Lynn H. Bimler, Kelsey E. Mauk, Léa Lortal, Nessim Kichik, James S. Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J. Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik, David B. Corry
Cell Rep. Author manuscript; available in PMC 2023 Dec 28.
Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113240. Published online 2023 Oct 17. doi: 10.1016/j.celrep.2023.113240
PMCID:
PMC10753853
AbstractArticlePDF–1.6M
3.
Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
Annie Y. Yao, Patrick J. Halloran, Yingying Ge, Neeraj Singh, John Zhou, James Galske, Wanxia He, Riqiang Yan, Xiangyou Hu
J Neurosci. 2023 Aug 30; 43(35): 6197–6211. doi: 10.1523/JNEUROSCI.2124-22.2023
PMCID:
PMC10476643
AbstractArticlePDF–3.9M
4.
β-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration
Xiaoping Qi, Carolina Francelin, Sayak Mitter, Sanford L. Boye, Hongmei Gu, Judith Quigley, Maria B. Grant, Michael E. Boulton
Mol Ther. 2023 Jul 5; 31(7): 2042–2055. Published online 2023 Apr 3. doi: 10.1016/j.ymthe.2023.03.029
PMCID:
PMC10362394
AbstractArticlePDF–7.7M
5.
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation
Gui-Feng Zhou, Jing Tang, Yuan-Lin Ma, Xian Fu, Jun-Yan Liu, Ren-Zhi Yang, Hong-Sheng Zhang, Xiang-Hai Cai, Jing-Wen Wang, Xiao-Yong Xie, Li Song, Biao Luo, Jian Chen, Long Chen, Xiao-Juan Deng, Guo-Jun Chen
Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2220148120. Published online 2023 May 22. doi: 10.1073/pnas.2220148120
PMCID:
PMC10235968
AbstractArticlePDF–6.5M
6.
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan
Mol Neurodegener. 2023; 18: 31. Published online 2023 May 4. doi: 10.1186/s13024-023-00611-w
PMCID:
PMC10161466
AbstractArticlePDF–10M
7.
Progressive spread of beta-amyloid pathology in an olfactory-driven APP mouse model
Helen C. Murray, Galit Saar, Li Bai, Nadia Bouraoud, Stephen Dodd, Blake Highet, Brigid Ryan, Maurice A. Curtis, Alan Koretsky, Leonardo Belluscio
Neuroscience. Author manuscript; available in PMC 2024 Apr 15.
Published in final edited form as: Neuroscience. 2023 Apr 15; 516: 113–124. Published online 2023 Jan 28. doi: 10.1016/j.neuroscience.2023.01.009
PMCID:
PMC10065898
AbstractArticlePDF–2.3M
8.
Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
Marc R Benoit, Mabintou Darboe, Brati Das, Yingying Ge, John Zhou, Annie Yao, Wanxia He, Riqiang Yan, Xiangyou Hu
Hum Mol Genet. 2023 Apr 1; 32(7): 1193–1207. Published online 2022 Nov 12. doi: 10.1093/hmg/ddac282
PMCID:
PMC10026251
AbstractArticlePDF–2.1M
9.
The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Mol Neurodegener. 2023; 18: 13. Published online 2023 Feb 21. doi: 10.1186/s13024-023-00596-6
PMCID:
PMC9942414
AbstractArticlePDF–2.3M
10.
Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals
Rangjuan Cao, Peng Chen, Hongsheng Wang, Hongyang Jing, Hongsheng Zhang, Guanglin Xing, Bin Luo, Jinxiu Pan, Zheng Yu, Wen-Cheng Xiong, Lin Mei
Nat Commun. 2023; 14: 744. Published online 2023 Feb 10. doi: 10.1038/s41467-023-36454-8
PMCID:
PMC9918736
AbstractArticlePDF–4.0M
11.
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup
Sci Rep. 2023; 13: 2216. Published online 2023 Feb 7. doi: 10.1038/s41598-023-28846-z
PMCID:
PMC9905473
AbstractArticlePDF–3.1M
12.
PS1 Affects the Pathology of Alzheimer’s Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus
Nuomin Li, Yunjie Qiu, Hao Wang, Juan Zhao, Hong Qing
Int J Mol Sci. 2022 Dec; 23(24): 16151. Published online 2022 Dec 18. doi: 10.3390/ijms232416151
PMCID:
PMC9782474
AbstractArticlePDF–3.5M
13.
The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes
Ryan Keable, Shangfeng Hu, Grant Pfundstein, Irina Kozlova, Feifei Su, Ximing Du, Hongyuan Yang, Jenny Gunnersen, Melitta Schachner, Iryna Leshchyns’ka, Vladimir Sytnyk
Cell Mol Life Sci. 2022; 79(11): 555. Published online 2022 Oct 17. doi: 10.1007/s00018-022-04575-w
PMCID:
PMC9576659
AbstractArticlePDF–18M
14.
Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing
Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang
Alzheimers Res Ther. 2022; 14: 103. Published online 2022 Jul 26. doi: 10.1186/s13195-022-01050-3
PMCID:
PMC9316766
AbstractArticlePDF–7.1M
15.
Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan
Sci Adv. 2022 Jul; 8(29): eabo3610. Published online 2022 Jul 20. doi: 10.1126/sciadv.abo3610
PMCID:
PMC9299535
AbstractArticlePDF–5.5M
16.
BACE1: More than just a β‐secretase
Hannah A. Taylor, Lena Przemylska, Eva M. Clavane, Paul J. Meakin
Obes Rev. 2022 Jul; 23(7): e13430. Published online 2022 Feb 4. doi: 10.1111/obr.13430
PMCID:
PMC9286785
AbstractArticlePDF–12M
17.
Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription
De‐Juan Yuan, Guang Yang, Wei Wu, Qi‐Fa Li, De‐en Xu, Michael Ntim, Chun‐Yan Jiang, Ji‐Chuan Liu, Yue Zhang, Ying‐Zi Wang, Dan‐Dan Zhu, Supratik Kundu, Ai‐Ping Li, Zhi‐Cheng Xiao, Quan‐Hong Ma, Shao Li
Aging Cell. 2022 May; 21(5): e13593. Published online 2022 Mar 30. doi: 10.1111/acel.13593
PMCID:
PMC9124306
AbstractArticlePDF–3.3M
18.
BACE1 controls synaptic function through modulating release of synaptic vesicles
Brati Das, Neeraj Singh, Annie Y. Yao, John Zhou, Wanxia He, Xiangyou Hu, Riqiang Yan
Mol Psychiatry. 2021; 26(11): 6394–6410. Published online 2021 Jun 22. doi: 10.1038/s41380-021-01166-2
PMCID:
PMC8760050
AbstractArticlePDF–4.3M
19.
MiR-29c-3p May Promote the Progression of Alzheimer's Disease through BACE1
Yanqun Cao, Xiangxiang Tan, Quzhe Lu, Kai Huang, Xiaoer Tang, Zhiming He
J Healthc Eng. 2021; 2021: 2031407. Published online 2021 Dec 15. doi: 10.1155/2021/2031407
PMCID:
PMC8695038
AbstractArticlePDF–1.3M
20.
The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system
Johanna Tüshaus, Stephan A. Müller, Joshua Shrouder, Martina Arends, Mikael Simons, Nikolaus Plesnila, Carl P. Blobel, Stefan F. Lichtenthaler
FASEB J. Author manuscript; available in PMC 2022 Nov 1.
Published in final edited form as: FASEB J. 2021 Nov; 35(11): e21962. doi: 10.1096/fj.202100936R
PMCID:
PMC8624807
AbstractArticlePDF–1.3M

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