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Select item 110324641.

USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy

Haiou Li, Yishuang Sun, Yingmeng Yao, Shanwen Ke, Nannan Zhang, Wenjun Xiong, Jie Shi, Chuan He, Xiangling Xiao, Haisheng Yu, Panpan Dai, Bolin Xiang, Xixin Xing, Gaoshan Xu, Wenjing Song, Jiquan Song, Jinfang Zhang

Proc Natl Acad Sci U S A. 2024 Apr 16; 121(16): e2315541121. Published online 2024 Apr 10. doi: 10.1073/pnas.2315541121

Correction in:: Proc Natl Acad Sci U S A. 2024 Jun 18; 121(25): e2409669121.

PMCID:: PMC11032464

Abstract Article PDF–2.1M

Select item 108634132.

Brucella targets the host ubiquitin-specific protease, Usp8, through the effector protein, TcpB, for facilitating infection of macrophages

Kiranmai Joshi, Varadendra Mazumdar, Binita Roy Nandi, Girish K. Radhakrishnan

Infect Immun. 2024 Feb; 92(2): e00289-23. Published online 2024 Jan 4. doi: 10.1128/iai.00289-23

PMCID:: PMC10863413

Abstract Article PDF–2.4M

Select item 99504323.

Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer

Hanshen Yang, Xiaozhen Zhang, Mengyi Lao, Kang Sun, Lihong He, Jian Xu, Yi Duan, Yan Chen, Honggang Ying, Muchun Li, Chengxiang Guo, Qingsong Lu, Sicheng Wang, Wei Su, Tingbo Liang, Xueli Bai

Cell Death Differ. 2023 Feb; 30(2): 560–575. Published online 2022 Dec 20. doi: 10.1038/s41418-022-01102-z

PMCID:: PMC9950432

Abstract Article PDF–13M

Select item 96444274.

Ubiquitin-specific protease 8 ameliorates lipopolysaccharide-induced spleen injury via suppression of NF-κB and MAPK signaling pathways

Wei Bi, Jiawei Zhang, Zhaohao Zeng, Ruiyi Zhou, Jiayi Zhao, Wei Yan, Lu Wang, Xiaoting Li, Lihong Zhu

Mol Med Rep. 2022 Dec; 26(6): 370. Published online 2022 Oct 31. doi: 10.3892/mmr.2022.12887

PMCID:: PMC9644427

Abstract Article PDF–2.6M

Select item 89714255.

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

Wenjun Xiong, Xueliang Gao, Tiantian Zhang, Baishan Jiang, Ming-Ming Hu, Xia Bu, Yang Gao, Lin-Zhou Zhang, Bo-Lin Xiao, Chuan He, Yishuang Sun, Haiou Li, Jie Shi, Xiangling Xiao, Bolin Xiang, Conghua Xie, Gang Chen, Haojian Zhang, Wenyi Wei, Gordon J. Freeman, Hong-Bing Shu, Haizhen Wang, Jinfang Zhang

Nat Commun. 2022; 13: 1700. Published online 2022 Mar 31. doi: 10.1038/s41467-022-29401-6

PMCID:: PMC8971425

Abstract Article PDF–4.2M

Select item 85086926.

Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling

Sachin Chaugule, Jung-Min Kim, Yeon-Suk Yang, Klaus-Peter Knobeloch, Xi He, Jae-Hyuck Shim

Int J Mol Sci. 2021 Oct; 22(19): 10289. Published online 2021 Sep 24. doi: 10.3390/ijms221910289

PMCID:: PMC8508692

Abstract Article PDF–2.4M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 66609068.

USP8 Deubiquitinates the Leptin Receptor and Is Necessary for Leptin-Mediated Synapse Formation

Tyler Bland, Gulcan Semra Sahin, Mingyan Zhu, Crystal Dillon, Soren Impey, Suzanne M Appleyard, Gary A Wayman

Endocrinology. 2019 Aug; 160(8): 1982–1998. Published online 2019 Jun 14. doi: 10.1210/en.2019-00107

PMCID:: PMC6660906

Abstract Article

Select item 64437849.

USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

Haifeng Gu, Xingxing Shi, Chao Liu, Chaoqun Wang, Ning Sui, Yu Zhao, Jiaqi Gong, Fuping Wang, Hong Zhang, Wei Li, Tongbiao Zhao

Nat Commun. 2019; 10: 1465. Published online 2019 Apr 1. doi: 10.1038/s41467-019-09430-4

PMCID:: PMC6443784

Abstract Article PDF–1.9M

Select item 626277710.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 428340611.

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

Thomas M Durcan, Matthew Y Tang, Joëlle R Pérusse, Eman A Dashti, Miguel A Aguileta, Gian-Luca McLelland, Priti Gros, Thomas A Shaler, Denis Faubert, Benoit Coulombe, Edward A Fon

EMBO J. 2014 Nov 3; 33(21): 2473–2491. Published online 2014 Sep 12. doi: 10.15252/embj.201489729

PMCID:: PMC4283406

Abstract Article PDF–3.7M

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253413.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 296610514.

Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex

Ilana Berlin, Heather Schwartz, Piers D. Nash

J Biol Chem. 2010 Nov 5; 285(45): 34909–34921. Published online 2010 Aug 24. doi: 10.1074/jbc.M109.016287

PMCID:: PMC2966105

Abstract Article PDF–4.5M

Select item 284414415.

Diacylglycerol Kinase δ and Protein Kinase Cα Modulate Epidermal Growth Factor Receptor Abundance and Degradation through Ubiquitin-specific Protease 8

Jinjin Cai, Tracy M. Crotty, Ethan Reichert, Kermit L. Carraway, III, Diana M. Stafforini, Matthew K. Topham

J Biol Chem. 2010 Mar 5; 285(10): 6952–6959. Published online 2010 Jan 11. doi: 10.1074/jbc.M109.055731

PMCID:: PMC2844144

Abstract Article PDF–1.0M

Select item 255627016.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 195150417.

Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo

Sandra Niendorf, Alexander Oksche, Agnes Kisser, Jürgen Löhler, Marco Prinz, Hubert Schorle, Stephan Feller, Marc Lewitzky, Ivan Horak, Klaus-Peter Knobeloch

Mol Cell Biol. 2007 Jul; 27(13): 5029–5039. Published online 2007 Apr 23. doi: 10.1128/MCB.01566-06