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Items: 1 to 20 of 181

1.
Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing
José J. M. Vitória, Diogo Trigo, Odete A. B. da Cruz e Silva
Cell Mol Life Sci. 2022 Feb; 79(2): 101. Published online 2022 Jan 28. doi: 10.1007/s00018-021-04090-4
PMCID:
PMC11073327
AbstractArticlePDF–1013K
2.
Genetic architecture of hippocampus subfields volumes in Alzheimer’s disease
Jiahui Cai, Weixue Xiong, Xueqin Wang, Haizhu Tan, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Database
CNS Neurosci Ther. 2024 Mar; 30(3): e14110. Published online 2023 Feb 8. doi: 10.1111/cns.14110
PMCID:
PMC10915996
AbstractArticlePDF–3.3M
3.
m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling
Xidi Wang, Yu Liu, Miao Zhou, Lei Yu, Zizhen Si
J Exp Clin Cancer Res. 2023; 42: 306. Published online 2023 Nov 21. doi: 10.1186/s13046-023-02881-0
PMCID:
PMC10661562
AbstractArticlePDF–15M
4.
APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
Sandra Roselli, Tugce Munise Satir, Rafael Camacho, Stefanie Fruhwürth, Petra Bergström, Henrik Zetterberg, Lotta Agholme
Cell Mol Neurobiol. 2023; 43(7): 3653–3668. Published online 2023 Jun 24. doi: 10.1007/s10571-023-01374-0
PMCID:
PMC10477112
AbstractArticlePDF–6.4M
5.
Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation
Jianfeng Zhuang, Yang Cao, Gengyin Guo, Maogui Li, Tongfu Zhang, Dong He, Jinyan Chen, Keke Zhang, Zhen Zhang
Aging (Albany NY) 2023 Aug 15; 15(15): 7709–7726. Published online 2023 Aug 7. doi: 10.18632/aging.204935
PMCID:
PMC10457076
AbstractArticlePDF–1.6M
6.
β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
Roberto A. Galeana-Ascencio, Liliana Mendieta, Daniel I. Limon, Dino Gnecco, Joel L. Terán, María L. Orea, Alan Carrasco-Carballo
Int J Mol Sci. 2023 May; 24(9): 8164. Published online 2023 May 3. doi: 10.3390/ijms24098164
PMCID:
PMC10179340
AbstractArticlePDF–3.4M
7.
Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium
Tongrong He, Livius V d’Uscio, Ruohan Sun, Anantha Vijay R Santhanam, Zvonimir S Katusic
J Cereb Blood Flow Metab. 2022 Oct; 42(10): 1920–1932. Published online 2022 Jun 8. doi: 10.1177/0271678X221105683
PMCID:
PMC9536128
AbstractArticlePDF–689K
8.
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells
Ji-Young Choi, Jung Hyun Park, Chulman Jo, Kyung-Chang Kim, Young Ho Koh
Biochem Biophys Res Commun. 2022 Oct 20; 626: 66–71. Published online 2022 Aug 4. doi: 10.1016/j.bbrc.2022.07.113
PMCID:
PMC9349051
AbstractArticlePDF–1.1M
9.
Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus
Lou Fourriere, Ellie Hyun‐Jung Cho, Paul A. Gleeson
Traffic. 2022 Mar; 23(3): 158–173. Published online 2022 Feb 13. doi: 10.1111/tra.12831
PMCID:
PMC9303681
AbstractArticlePDF–24M
10.
BACE1: More than just a β‐secretase
Hannah A. Taylor, Lena Przemylska, Eva M. Clavane, Paul J. Meakin
Obes Rev. 2022 Jul; 23(7): e13430. Published online 2022 Feb 4. doi: 10.1111/obr.13430
PMCID:
PMC9286785
AbstractArticlePDF–12M
11.
Post-Translational Modifications of BACE1 in Alzheimer's Disease
Wen Wen, Ping Li, Panwang Liu, Shijun Xu, Fushun Wang, Jason H Huang
Curr Neuropharmacol. 2022 Jan 10; 20(1): 211–222. Published online 2022 Jan 10. doi: 10.2174/1570159X19666210121163224
PMCID:
PMC9199555
AbstractArticlePDF–1.9M
12.
Increased Serum Beta-Secretase 1 Activity is an Early Marker of Alzheimer’s Disease
Roland Nicsanu, Carlo Cervellati, Luisa Benussi, Rosanna Squitti, Roberta Zanardini, Valentina Rosta, Alessandro Trentini, Clarissa Ferrari, Claudia Saraceno, Antonio Longobardi, Sonia Bellini, Giuliano Binetti, Orazio Zanetti, Giovanni Zuliani, Roberta Ghidoni
J Alzheimers Dis. 2022; 87(1): 433–441. Prepublished online 2022 Mar 11. Published online 2022 May 3. doi: 10.3233/JAD-215542
PMCID:
PMC9198762
AbstractArticlePDF–393K
13.
Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease: Data from the PUMCH Dementia Cohort
Liling Dong, Chenhui Mao, Caiyan Liu, Jie Li, Xinying Huang, Jie Wang, Dan Lei, Shanshan Chu, Longze Sha, Qi Xu, Bin Peng, Liying Cui, Jing Gao
J Alzheimers Dis. 2022; 85(4): 1511–1518. Prepublished online 2021 Dec 21. Published online 2022 Feb 15. doi: 10.3233/JAD-215067
PMCID:
PMC8925115
AbstractArticlePDF–288K
14.
Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation
Ruizhi Wang, Debomoy K. Lahiri
Sci Rep. 2022; 12: 3074. Published online 2022 Feb 23. doi: 10.1038/s41598-022-05164-4
PMCID:
PMC8866491
AbstractArticlePDF–2.0M
15.
MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
Nipun Chopra, Ruizhi Wang, Bryan Maloney, Kwangsik Nho, John S. Beck, Naemeh Pourshafie, Alexander Niculescu, Andrew J. Saykin, Carlo Rinaldi, Scott E. Counts, Debomoy K. Lahiri
Mol Psychiatry. 2021; 26(10): 5636–5657. Published online 2020 Jan 15. doi: 10.1038/s41380-019-0610-2
PMCID:
PMC8758483
AbstractArticlePDF–2.8M
16.
Early elevation of BACE1 in dementia
Carlo Cervellati, Giuseppe Valacchi, Giovanni Zuliani
Aging (Albany NY) 2021 Nov 30; 13(22): 24480–24481. Published online 2021 Nov 29. doi: 10.18632/aging.203727
PMCID:
PMC8660596
ArticlePDF–298K
17.
Two Rare Variants in PLAU and BACE1 Genes—Do They Contribute to Semantic Dementia Clinical Phenotype?
Katarzyna Gaweda-Walerych, Emilia J. Sitek, Małgorzata Borczyk, Mariusz Berdyński, Ewa Narożańska, Bogna Brockhuis, Michał Korostyński, Jarosław Sławek, Cezary Zekanowski
Genes (Basel) 2021 Nov; 12(11): 1806. Published online 2021 Nov 17. doi: 10.3390/genes12111806
PMCID:
PMC8624613
AbstractArticlePDF–1.6M
18.
Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome‐wide association study in over 12,000 non‐demented participants
Vincent Damotte, Sven J. van der Lee, Vincent Chouraki, Benjamin Grenier‐Boley, Jeannette Simino, Hieab Adams, Giuseppe Tosto, Charles White, Natalie Terzikhan, Carlos Cruchaga, Maria J. Knol, Shuo Li, Susanna Schraen, Megan L. Grove, Claudia Satizabal, Najaf Amin, Claudine Berr, Steven Younkin, Alzheimer's Disease Neuroimaging Initiative, Rebecca F. Gottesman, Luc Buée, Alexa Beiser, David S. Knopman, Andre Uitterlinden, Charles DeCarli, Jan Bressler, Anita DeStefano, Jean‐François Dartigues, Qiong Yang, Eric Boerwinkle, Christophe Tzourio, Myriam Fornage, M. Arfan Ikram, Philippe Amouyel, Phil de Jager, Christiane Reitz, Thomas H. Mosley, Jean‐Charles Lambert, Sudha Seshadri, Cornelia M. van Duijn
Alzheimers Dement. 2021 Oct; 17(10): 1663–1674. Published online 2021 May 18. doi: 10.1002/alz.12333
PMCID:
PMC8597077
AbstractArticlePDF–808K
19.
Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling
Catarina Perdigão, Mariana A. Barata, Tatiana Burrinha, Cláudia Guimas Almeida
J Biol Chem. 2021 Sep; 297(3): 101056. Published online 2021 Aug 8. doi: 10.1016/j.jbc.2021.101056
PMCID:
PMC8413894
AbstractArticlePDF–3.9M
20.
1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors
Dawid Maliszewski, Agnieszka Wróbel, Beata Kolesińska, Justyna Frączyk, Danuta Drozdowska
Molecules. 2021 Jul; 26(13): 3942. Published online 2021 Jun 28. doi: 10.3390/molecules26133942
PMCID:
PMC8271926
AbstractArticlePDF–1.7M

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