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Select item 112139531.

PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu, Jonathan Gurkan, Yi Bao, Mahnoor Gondal, Jean Ching-Yi Tien, Tomasz Maj, Sahr Yazdani, Abhijit Parolia, Houjun Xia, JiaJia Zhou, Shuang Wei, Sara Grove, Linda Vatan, Heng Lin, Gaopeng Li, Yang Zheng, Yuping Zhang, Xuhong Cao, Fengyun Su, Rui Wang, Tongchen He, Marcin Cieslik, Michael D. Green, Weiping Zou, Arul M. Chinnaiyan

Nat Commun. 2024; 15: 5487. Published online 2024 Jun 28. doi: 10.1038/s41467-024-48931-9

PMCID:: PMC11213953

Abstract Article PDF–1.8M

Select item 107199272.

Reprogramming tumour-associated macrophages to outcompete cancer cells

Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li

Nature. Author manuscript; available in PMC 2023 Dec 14.

Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5

PMCID:: PMC10719927

Abstract Article PDF–5.6M

Select item 100620123.

PIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS

Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zlokovic, Dion K. Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin K. Ichida

Cell. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Cell. 2023 Feb 16; 186(4): 786–802.e28. Published online 2023 Feb 7. doi: 10.1016/j.cell.2023.01.005

PMCID:: PMC10062012

Abstract Article PDF–3.2M

Select item 93047914.

Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity

Golam T. Saffi, Cheng An Wang, Emily M. Mangialardi, Jean Vacher, Roberto J. Botelho, Leonardo Salmena

J Biol Chem. 2022 Aug; 298(8): 102187. Published online 2022 Jun 26. doi: 10.1016/j.jbc.2022.102187

PMCID:: PMC9304791

Abstract Article PDF–3.0M

Select item 90670835.

Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity

Min Gu, Zhen Wang, Feifei Feng, Yongjian Yang, Xiongshan Sun, Dachun Yang

J Cardiovasc Pharmacol. 2022 May; 79(5): 739–748. Published online 2022 Mar 11. doi: 10.1097/FJC.0000000000001243

PMCID:: PMC9067083

Abstract Article PDF–950K

Select item 80988146.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 71977508.

PI(4,5)P₂ regulates plasma cholesterol through LDL receptor lysosomal degradation

Yuanyuan Qin, Flora Ting, Mee J Kim, Jacob Strelnikov, Joseph Harmon, Feng Gao, Andrea Dose, Ba-Bie Teng, M. Amir Alipour, Zemin Yao, Rosanne Crooke, Ronald M. Krauss, Marisa W. Medina

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 May; 40(5): 1311–1324. Published online 2020 Mar 19. doi: 10.1161/ATVBAHA.120.314033

PMCID:: PMC7197750

Abstract Article PDF–2.1M

Select item 67916549.

PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice

Sang Hee Min, Aae Suzuki, Lehn Weaver, Jessica Guzman, Yutein Chung, Huiyan Jin, Francina Gonzalez, Claire Trasorras, Liang Zhao, Lynn A. Spruce, Steven H. Seeholzer, Edward M. Behrens, Charles S. Abrams

Mol Cell Biol. 2019 Nov 1; 39(21): e00158-19. Prepublished online 2019 Aug 19. Published online 2019 Oct 11. doi: 10.1128/MCB.00158-19

PMCID:: PMC6791654

Abstract Article PDF–4.8M

Select item 603133110.

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Christopher H. Choy, Golam Saffi, Matthew A. Gray, Callen Wallace, Roya M. Dayam, Zhen-Yi A. Ou, Guy Lenk, Rosa Puertollano, Simon C. Watkins, Roberto J. Botelho

J Cell Sci. 2018 May 15; 131(10): jcs213587. Published online 2018 May 21. doi: 10.1242/jcs.213587

PMCID:: PMC6031331

Abstract Article

Select item 588918511.

PIKfyve regulates melanosome biogenesis

Marc C. Liggins, Jessica L. Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E. Boissy, Anand K. Ganesan

PLoS Genet. 2018 Mar; 14(3): e1007290. Published online 2018 Mar 27. doi: 10.1371/journal.pgen.1007290

PMCID:: PMC5889185

Abstract Article PDF–23M

Select item 547004212.

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice

Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, Taro Kawai

EMBO J. 2017 Jun 14; 36(12): 1707–1718. Published online 2017 May 22. doi: 10.15252/embj.201695528

PMCID:: PMC5470042

Abstract Article PDF–1.5M

Select item 545204813.

Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice

Helene Tronchere, Mathieu Cinato, Andrei Timotin, Laurie Guitou, Camille Villedieu, Helene Thibault, Delphine Baetz, Bernard Payrastre, Philippe Valet, Angelo Parini, Oksana Kunduzova, Frederic Boal

EMBO Mol Med. 2017 Jun; 9(6): 770–785. Published online 2017 Apr 10. doi: 10.15252/emmm.201607096

PMCID:: PMC5452048

Abstract Article PDF–3.0M

Select item 529357914.

A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity

Benjamin Guscott, Zita Balklava, Stephen T. Safrany, Thomas Wassmer

Biosci Rep. 2016 Apr; 36(2): e00319. Prepublished online 2016 Mar 2. Published online 2016 Apr 15. doi: 10.1042/BSR20160040

PMCID:: PMC5293579

Abstract Article PDF–1.7M

Select item 504683615.

PIKfyve regulates vacuole maturation and nutrient recovery following engulfment

Shefali Krishna, Wilhelm Palm, Yongchan Lee, Wendy Yang, Urmi Bandyopadhyay, Haoxing Xu, Oliver Florey, Craig B. Thompson, Michael Overholtzer

Dev Cell. Author manuscript; available in PMC 2017 Sep 12.

Published in final edited form as: Dev Cell. 2016 Sep 12; 38(5): 536–547. doi: 10.1016/j.devcel.2016.08.001

PMCID:: PMC5046836

Abstract Article PDF–2.1M

Select item 500464716.

Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells

Madhusudan Venkatareddy, Rakesh Verma, Anne Kalinowski, Sanjeevkumar R. Patel, Assia Shisheva, Puneet Garg

J Am Soc Nephrol. 2016 Sep; 27(9): 2702–2719. Published online 2016 Jan 29. doi: 10.1681/ASN.2015050555

PMCID:: PMC5004647

Abstract Article

Select item 490849017.

Unexpected severe consequences of Pikfyve deletion by aP2‐ or Aq‐promoter‐driven Cre expression for glucose homeostasis and mammary gland development

Ognian C. Ikonomov, Diego Sbrissa, Khortnal Delvecchio, James A. Rillema, Assia Shisheva

Physiol Rep. 2016 Jun; 4(11): e12812. Published online 2016 Jun 7. doi: 10.14814/phy2.12812

PMCID:: PMC4908490

Abstract Article PDF–2.2M

Select item 488932818.

PI(3,5)P₂ biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

Yevgeniya A Mironova, Guy M Lenk, Jing-Ping Lin, Seung Joon Lee, Jeffery L Twiss, Ilaria Vaccari, Alessandra Bolino, Leif A Havton, Sang H Min, Charles S Abrams, Peter Shrager, Miriam H Meisler, Roman J Giger

eLife. 2016; 5: e13023. Published online 2016 Mar 23. doi: 10.7554/eLife.13023

PMCID:: PMC4889328

Abstract Article PDF–6.1M

Select item 456003919.

Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity

Kachiko Hayashi, Miwa Sasai, Akiko Iwasaki

Int Immunol. 2015 Sep; 27(9): 435–445. Published online 2015 Apr 29. doi: 10.1093/intimm/dxv021

PMCID:: PMC4560039

Abstract Article PDF–2.9M

Select item 443154420.

Class III PI 3-Kinase is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Podocyte Endomembrane Homeostasis

Ognian C. Ikonomov, Diego Sbrissa, Madhusudan Venkatareddy, Ellen Tisdale, Puneet Garg, Assia Shisheva

Biochim Biophys Acta. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Biochim Biophys Acta. 2015 May; 1853(5): 1240–1250. Published online 2015 Jan 22. doi: 10.1016/j.bbamcr.2015.01.008

PMCID:: PMC4431544

Abstract Article PDF–2.1M

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