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Select item 114034961.

USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion

Kexin Tang, Tingting Yin, Bo Deng, Min Wang, Zixuan Ren, Shuo Wang, Xiong Liu, Huiyan Li, Jingjing Wang, Yating Du, Jun Zhou, Yan Chen, Yijie Wang

J Biol Chem. 2024 Sep; 300(9): 107672. Published online 2024 Aug 14. doi: 10.1016/j.jbc.2024.107672

PMCID:: PMC11403496

Abstract Article PDF–4.6M

Select item 113691742.

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2024 Sep; 20(9): 1025–1048. Published online 2024 Jul 15. doi: 10.1038/s44320-024-00055-4

PMCID:: PMC11369174

Abstract Article PDF–2.7M

Select item 113159293.

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll

EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9

PMCID:: PMC11315929

Abstract Article PDF–3.4M

Select item 112969144.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112374185.

Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7

Zunlin Yang, John Nicholas

J Virol. 2024 Jun; 98(6): e00255-24. Published online 2024 May 16. doi: 10.1128/jvi.00255-24

PMCID:: PMC11237418

Abstract Article PDF–3.5M

Select item 112099356.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111481847.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094838.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110951409.

Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase

Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin

Adv Sci (Weinh) 2024 May; 11(18): 2307899. Published online 2024 Mar 9. doi: 10.1002/advs.202307899

PMCID:: PMC11095140

Abstract Article PDF–5.6M

Select item 1106914610.

The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis

Ruyue Zhang, Daidi Zhang, Fugen Han, Xiaorui Song, Yaodong Zhang, Jie Zhang, Qingwen Zhu, Yanru Qin

J Exp Clin Cancer Res. 2024; 43: 135. Published online 2024 May 4. doi: 10.1186/s13046-024-03056-1

PMCID:: PMC11069146

Abstract Article PDF–11M

Select item 1104069711.

Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis

Jie Li, Bin Zhang, Zishan Feng, Dandan An, Zhiyuan Zhou, Chao Wan, Yan Hu, Yajie Sun, Yijun Wang, Xixi Liu, Wenwen Wei, Xiao Yang, Jingshu Meng, Mengjie Che, Yuhan Sheng, Bian Wu, Lu Wen, Fang Huang, Yan Li, Kunyu Yang

J Exp Clin Cancer Res. 2024; 43: 28. Published online 2024 Jan 23. doi: 10.1186/s13046-024-02954-8

PMCID:: PMC11040697

Abstract Article PDF–13M

Select item 1102123312.

USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination

Na Wang, Jing Xu, Yujing Wang, Xuejiao Zhang, Hongzhen Zhang

J Cancer Res Clin Oncol. 2024; 150(4): 196. Published online 2024 Apr 16. doi: 10.1007/s00432-024-05710-9

PMCID:: PMC11021233

Abstract Article PDF–7.8M

Select item 1092387613.

Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Bin Zhang, Jie Li, Yijun Wang, Xixi Liu, Xiao Yang, Zhiyun Liao, Suke Deng, Yue Deng, Zhiyuan Zhou, Yu Tian, Wenwen Wei, Jingshu Meng, Yan Hu, Chao Wan, Zhanjie Zhang, Fang Huang, Lu Wen, Bian Wu, Yajie Sun, Yan Li, Kunyu Yang

Cell Death Differ. 2024 Mar; 31(3): 309–321. Published online 2024 Jan 29. doi: 10.1038/s41418-024-01257-x

PMCID:: PMC10923876

Abstract Article PDF–8.3M

Select item 1081909614.

SP1‐activated USP27X‐AS1 promotes hepatocellular carcinoma progression via USP7‐mediated AKT stabilisation

Chen Su, Haoquan Zhang, Jie Mo, Zhibin Liao, Bixiang Zhang, Peng Zhu

Clin Transl Med. 2024 Jan; 14(1): e1563. Published online 2024 Jan 27. doi: 10.1002/ctm2.1563

PMCID:: PMC10819096

Abstract Article PDF–16M

Select item 1077786315.

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions

Haining Zhou, Wenzhi Feng, Juntao Yu, Tiasha A. Shafiq, Joao A. Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Danesh Moazed

Cell Rep. Author manuscript; available in PMC 2024 Apr 25.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112339. Published online 2023 Apr 3. doi: 10.1016/j.celrep.2023.112339

PMCID:: PMC10777863

Abstract Article PDF–1.9M

Select item 1076620716.

USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression

Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Ruiyu Xie, Xian Zhao, Jianxiu Yu

Mol Oncol. 2024 Jan; 18(1): 170–189. Published online 2023 Nov 2. doi: 10.1002/1878-0261.13543

PMCID:: PMC10766207

Abstract Article PDF–2.7M

Select item 1059748417.

USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7

Su Hyoun Lee, Kwang Chul Chung

PLoS One. 2023; 18(10): e0290371. Published online 2023 Oct 24. doi: 10.1371/journal.pone.0290371

Correction in:: PLoS One. 2024; 19(1): e0297970.

PMCID:: PMC10597484

Abstract Article PDF–2.1M

Select item 1053132518.

USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation

Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E. Zage

Int J Mol Sci. 2023 Sep; 24(18): 13780. Published online 2023 Sep 7. doi: 10.3390/ijms241813780

PMCID:: PMC10531325

Abstract Article PDF–4.2M

Select item 1050265719.

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei

Adv Sci (Weinh) 2023 Sep; 10(26): 2303336. Published online 2023 Jul 12. doi: 10.1002/advs.202303336

PMCID:: PMC10502657

Abstract Article PDF–3.4M

Select item 1048053520.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

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